Compile Data Set for Download or QSAR
Found 167 with Last Name = 'twigg' and Initial = 'dg'
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50598056(CHEMBL403671)copy SMILES
Affinity DataKi: <0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50598057(CHEMBL254337)copy SMILES
Affinity DataKi: <0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50228954((E)-2-(6-(3-(2-(5-chlorothiophen-2-yl)vinylsulfona...)copy SMILEScopy InChI
Affinity DataKi:  0.400nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50228935((E)-2-(5-chloro-thiophen-2-yl)-ethenesulfonic acid...)copy SMILEScopy InChI
Affinity DataKi:  1.80nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50228946((E)-2-(5-chlorothiophen-2-yl)-N-(2-oxo-1-(5-(2-(tr...)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50228933((E)-2-(5-chlorothiophen-2-yl)-N-(1-(5-(2-(N-methyl...)copy SMILEScopy InChI
Affinity DataKi:  9.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50228939((E)-2-(6-(3-(2-(5-chlorothiophen-2-yl)vinylsulfona...)copy SMILEScopy InChI
Affinity DataKi:  12nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50228937((E)-2-(5-chloro-thiophen-2-yl)-ethenesulfonic acid...)copy SMILEScopy InChI
Affinity DataKi:  14nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50228929((E)-2-(5-chlorothiophen-2-yl)-N-(1-(5-(2-isopropox...)copy SMILEScopy InChI
Affinity DataKi:  180nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCoagulation factor X(Homo sapiens (Human))TBA
LigandPNGBDBM50228942((E)-N-(1-(5-(2-tert-butylphenyl)pyridin-2-yl)-2-ox...)copy SMILEScopy InChI
Affinity DataKi:  2.33E+3nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCathepsin S(Homo sapiens (Human))TBA
LigandPNGBDBM240596(US9409882, 1)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCathepsin S(Homo sapiens (Human))TBA
LigandPNGBDBM130413(US8822505, 13)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
TargetCathepsin S(Homo sapiens (Human))TBA
LigandPNGBDBM130402(US8822505, 2)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
LigandPNGBDBM50546218(CHEMBL4741490 | US11466016, Example 114)copy SMILES
Affinity DataIC50: 3nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575964((1R,2S,3S,5S)-8-[3-(5- chloro-3-methoxy- quinoxali...)copy SMILES
Affinity DataIC50: 3nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575962((1R,2S,3S,5S)-8-[3-(3,4- Dichloro-2-methyl-2H- ind...)copy SMILES
Affinity DataIC50: 3.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575913(US11466016, Example 41 | exo-8-[7-(3,4- dichloro-2...)copy SMILES
Affinity DataIC50: 3.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575966(US11466016, Example 98 | {6-[(1R,2S,3S,5S)- 3-amin...)copy SMILES
Affinity DataIC50: 4nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))TBA
LigandPNGBDBM155979(US9018214, 30)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
LigandPNGBDBM575896(US11466016, Example 24 | endo-8-[7-(3,4- dichloro-...)copy SMILES
Affinity DataIC50: 4.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575937(5-{3-[endo-3-amino-8- azabicyclo[3.2.1]octan- 8-yl...)copy SMILES
Affinity DataIC50: 4.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575965(7-{6-[(1R,2S,3S,5S)- 3-amino-2-fluoro-8- azabicycl...)copy SMILES
Affinity DataIC50: 4.70nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
TargetProcathepsin L(Homo sapiens (Human))TBA
LigandPNGBDBM130413(US8822505, 13)copy SMILEScopy InChI
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
LigandPNGBDBM575995(5-{6- [(1R,2S,3S,5S)-3- amino-2-fluoro-8- azabi...)copy SMILES
Affinity DataIC50: 5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575951(US11466016, Example 80 | {6-[(1R,2S,3S,5S)-3- amin...)copy SMILES
Affinity DataIC50: 5.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575895(6-{3-[endo-3- amino-8- azabicyclo[3.2.1] octan-8-y...)copy SMILES
Affinity DataIC50: 5.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575988(US11466016, Example 122 | {3- [(1R,2S,3S,5S)-3- am...)copy SMILES
Affinity DataIC50: 5.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575983(US11466016, Example 118 | {6-[(1R,2S,3S,5S)- 3-ami...)copy SMILES
Affinity DataIC50: 5.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575915(US11466016, Example 43 | endo-8-{7-[7- chloro-2- (...)copy SMILES
Affinity DataIC50: 5.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))TBA
LigandPNGBDBM155971(US9018214, 22)copy SMILEScopy InChI
Affinity DataIC50: 5.90nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5CTCPubMed
LigandPNGBDBM575886(US11466016, Example 15 | endo-8-[7-(7- chloro-2- m...)copy SMILES
Affinity DataIC50: 5.90nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575999(US11466016, Example 133 | {6-[endo-3-amino-8- aza...)copy SMILES
Affinity DataIC50: 6nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575908(2-(5-{3-[endo- 3-amino-8- azabicyclo[3.2.1] octan-...)copy SMILES
Affinity DataIC50: 6nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM576010(US11466016, Example 143 | {6-[(1R,2S,3S,5S)- 3-am...)copy SMILES
Affinity DataIC50: 6.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575884(US11466016, Example 13 | endo-8-[7-(7- chloro-1,3-...)copy SMILES
Affinity DataIC50: 6.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575975(US11466016, Example 108 | {6-[(1R,2S,3S,5S)- 3-ami...)copy SMILES
Affinity DataIC50: 6.60nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575941(US11466016, Example 69 | endo-8-(7-{4-chloro-2- [(...)copy SMILES
Affinity DataIC50: 6.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575916((6-{3-[endo-3- amino-8- azabicyclo [3.2.1]octan- 8...)copy SMILES
Affinity DataIC50: 6.80nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575911(US11466016, Example 39 | endo-8-{7-[7- chloro-2- (...)copy SMILES
Affinity DataIC50: 6.90nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575977(US11466016, Example 110 | [6-(4-amino-4- methylpip...)copy SMILES
Affinity DataIC50: 7nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575934(5-{3-[endo-3-amino-8- azabicyclo[3.2.1]octan- 8-yl...)copy SMILES
Affinity DataIC50: 7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575991(6-[3,9- diazabicyclo[3.3.1] nonan-9-yl]-3-(3,4- ...)copy SMILES
Affinity DataIC50: 7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575959(US11466016, Example 88 | {6-[endo-3-amino-8- azabi...)copy SMILES
Affinity DataIC50: 7.10nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575957(US11466016, Example 86 | {6-[3,8- diazabicyclo[3.2...)copy SMILES
Affinity DataIC50: 7.20nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575994(US11466016, Example 128 | {6-[endo-3- amino-8- az...)copy SMILES
Affinity DataIC50: 7.30nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575955(US11466016, Example 84 | {6-[(1R,2S,3S,5S)-3- amin...)copy SMILES
Affinity DataIC50: 7.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575979(US11466016, Example 113 | {6-[endo-3-amino- 8-aza-...)copy SMILES
Affinity DataIC50: 7.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM576015((1S,2S,3S,5R)-8-[3- (7-chloro-2-methyl- 1,3-benz...)copy SMILES
Affinity DataIC50: 7.40nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575981(US11466016, Example 116 | {6-[endo-3-amino- 3-meth...)copy SMILES
Affinity DataIC50: 7.5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
LigandPNGBDBM575956(US11466016, Example 85 | {6-[(1S,2S,3S,5R)-3- amin...)copy SMILES
Affinity DataIC50: 7.5nMAssay Description:SHP2 activity was monitored by measuring the conversion of the surrogate substrate 6,8-difluoromethylumbelliferyl phosphate (DiFMUP) to the fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2Z322WKUS Patent
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