Compile Data Set for Download or QSAR
Found 27 with Last Name = 'pon' and Initial = 'dj'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128419(1-{5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-...)copy SMILEScopy InChI
Affinity DataKi:  1.18E+3nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50409702(CHEMBL2112296)copy SMILEScopy InChI
Affinity DataKi:  2.10E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50409699(CHEMBL2112294)copy SMILEScopy InChI
Affinity DataKi:  2.24E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128424(2-{5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-...)copy SMILEScopy InChI
Affinity DataKi:  2.27E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128424(2-{5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-...)copy SMILEScopy InChI
Affinity DataKi:  2.27E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128686(2-{5-[1-(3-Cyclobutoxy-4-difluoromethoxy-phenyl)-2...)copy SMILEScopy InChI
Affinity DataKi:  2.50E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128689(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  2.64E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128689(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  2.64E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50409700(CHEMBL2112295)copy SMILEScopy InChI
Affinity DataKi:  3.81E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50409701(CHEMBL383762)copy SMILEScopy InChI
Affinity DataKi:  3.90E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128683(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  4.22E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128683(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  4.47E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128692(5-{2-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-2-[...)copy SMILEScopy InChI
Affinity DataKi:  5.59E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128685(2-{5-[1-(3-Cyclobutoxy-4-difluoromethoxy-phenyl)-2...)copy SMILEScopy InChI
Affinity DataKi:  5.84E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)copy SMILEScopy InChI
Affinity DataKi:  6.14E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128685(2-{5-[1-(3-Cyclobutoxy-4-difluoromethoxy-phenyl)-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128692(5-{2-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-2-[...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128686(2-{5-[1-(3-Cyclobutoxy-4-difluoromethoxy-phenyl)-2...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128683(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128683(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128419(1-{5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50064858((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...)copy SMILEScopy InChI
Affinity DataIC50: 4.30nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128424(2-{5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128424(2-{5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128690(4-Hydroxy-7-{2-[2-(3-phenethyloxy-propane-1-sulfon...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128689(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128689(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed