Compile Data Set for Download or QSAR
Found 846 with Last Name = 'andrews' and Initial = 'dm'
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50169743((13S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoro-pe...)copy SMILEScopy InChI
Affinity DataIC50: 0.0631nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125052(CHEMBL3623004 | US10130617, Example 1 | US20240043...)copy SMILEScopy InChI
Affinity DataIC50: 0.138nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cellsMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50084948(CHEMBL195515 | GW7604)copy SMILEScopy InChI
Affinity DataIC50: 0.145nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetProgesterone receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50169743((13S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoro-pe...)copy SMILEScopy InChI
Affinity DataIC50: 0.209nMAssay Description:Antagonist activity at progesterone receptor in human MCF cells assessed as estradiol-induced receptor responseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125052(CHEMBL3623004 | US10130617, Example 1 | US20240043...)copy SMILEScopy InChI
Affinity DataIC50: 0.209nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cells in presence of 0.25 uM tamoxifenMore data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125052(CHEMBL3623004 | US10130617, Example 1 | US20240043...)copy SMILEScopy InChI
Affinity DataIC50: 0.282nMAssay Description:Antagonist activity at progesterone receptor in human MCF cells assessed as estradiol-induced receptor responseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263148(CHEMBL476578 | N-((R)-1-(4-(5-fluoro-4-(1-isopropy...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24749PGPubMed
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)copy SMILEScopy InChI
Affinity DataIC50: 0.309nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125055(CHEMBL3623002)copy SMILEScopy InChI
Affinity DataIC50: 0.417nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263147(CHEMBL476577 | N-(1-(4-(5-fluoro-4-(1-isopropyl-2-...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24749PGPubMed
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125055(CHEMBL3623002)copy SMILEScopy InChI
Affinity DataIC50: 0.708nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetProgesterone receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM20608(4-Hydroxytamoxifen | 4-Hydroxytamoxifen (9) | 4-[(...)copy SMILEScopy InChI
Affinity DataIC50: 0.794nMAssay Description:Antagonist activity at progesterone receptor in human MCF cells assessed as estradiol-induced receptor responseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125052(CHEMBL3623004 | US10130617, Example 1 | US20240043...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125052(CHEMBL3623004 | US10130617, Example 1 | US20240043...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50169743((13S,17S)-13-Methyl-7-[9-(4,4,5,5,5-pentafluoro-pe...)copy SMILEScopy InChI
Affinity DataIC50: 0.813nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetProgesterone receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125055(CHEMBL3623002)copy SMILEScopy InChI
Affinity DataIC50: 0.832nMAssay Description:Antagonist activity at progesterone receptor in human MCF cells assessed as estradiol-induced receptor responseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125054(CHEMBL3623003 | US10130617, Example 2 | WO-2014/19...)copy SMILEScopy InChI
Affinity DataIC50: 0.851nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263028(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50107257(CHEMBL3600785)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of N-terminal FLAG-tagged human full length recombinant PI4K3alpha using D-myo-phosphatidylinositol substrate and ATP incubated for 45 min...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9DKRPubMed
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125054(CHEMBL3623003 | US10130617, Example 2 | WO-2014/19...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246406(2-fluoro-4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-im...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JNMPubMed
LigandPNGBDBM50599596(CHEMBL5191668)copy SMILES
Affinity DataIC50: 1.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3J18PubMed
LigandPNGBDBM50599618(CHEMBL5182242)copy SMILES
Affinity DataIC50: 1.5nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3J18PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246350(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2377PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246447(2-fluoro-4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-im...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2377PubMed
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50107256(CHEMBL3600784)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of N-terminal FLAG-tagged human full length recombinant PI4K3alpha using D-myo-phosphatidylinositol substrate and ATP incubated for 45 min...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KK9DKRPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50420961(CHEMBL2088096)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B62PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50420953(CHEMBL2088260)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X2B62PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM7657(4-[(4-{imidazo[1,2-a]pyridin-3-yl}pyrimidin-2-yl)a...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246408((4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JNMPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50245864(CHEMBL462385 | N-(2-(dimethylamino)ethyl)-2-fluoro...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JNMPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50245865(((S)-3-(dimethylamino)pyrrolidin-1-yl)(4-(5-fluoro...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50245910((4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JNMPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50245913((4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JNMPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246408((4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JNMPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246298(CHEMBL487067 | N-(2-hydroxyethyl)-4-(4-(1-isopropy...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2377PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246301(4-(4-(1-cyclopentyl-2-methyl-1H-imidazol-5-yl)pyri...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2377PubMed
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125077(CHEMBL3623001)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Antagonist activity at ERalpha receptor in human MCF7 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50420959(CHEMBL2088095)copy SMILEScopy InChI
Affinity DataIC50: 2.51nMAssay Description:Inhibition of recombinant N terminal GST-tagged human FGFR1 (456 to 765) expressed in baculovirus infected Sf21 cells after 40 mins by caliper mobili...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50025069(CHEMBL485425)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J9667KPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263068(CHEMBL477785 | N-(4-(4-(2-(dimethylamino)ethylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24749PGPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM7672(4-[(4-{imidazo[1,2-a]pyridazin-3-yl}pyrimidin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J9667KPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50025068(CHEMBL484555)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J9667KPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50263026(CHEMBL478407 | N-(4-fluorophenyl)-4-(1-isopropyl-2...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2/Cyclin E (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24749PGPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246349(4-(5-fluoro-4-(1-isopropyl-2-methyl-1H-imidazol-5-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2377PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246407(CHEMBL453629 | N-(2-(dimethylamino)ethyl)-2-fluoro...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XW4JNMPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246254(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2377PubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
AstraZeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50246255(4-(4-(1-isopropyl-2-methyl-1H-imidazol-5-yl)pyrimi...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23N2377PubMed
TargetEstrogen receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50041611((2E)-3-{4-[(1E)-1,2-DIPHENYLBUT-1-ENYL]PHENYL}ACRY...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Binding affinity to ERalpha receptor (unknown origin)More data for this Ligand-Target Pair
TargetProgesterone receptor(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50125054(CHEMBL3623003 | US10130617, Example 2 | WO-2014/19...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Antagonist activity at progesterone receptor in human MCF cells assessed as estradiol-induced receptor responseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2F76FCNPubMed
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