Compile Data Set for Download or QSAR
Found 35 with Last Name = 'madden' and Initial = 'dr'
TargetDisabled homolog 2(Human)
TRUSTEES OF DARTMOUTH COLLEGE

US Patent
LigandPNGBDBM62839(5,5-dimethyl-2,6-dihydro-[1,2,4]triazol[3,4-a]isoq...)copy SMILEScopy InChI
Affinity DataKi:  779nMAssay Description:Fluorescence polarization (FP) data were measured on a microplate reader (Tecan Infinite M1000, Mannedorf, Switzerland) at 27° C. For Kd measurements...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R214GFUS Patent
TargetDisabled homolog 2(Human)
TRUSTEES OF DARTMOUTH COLLEGE

US Patent
LigandPNGBDBM50262140((17beta)-estra-1,3,5(10)-triene-2,3,17-triol | 2-O...)copy SMILEScopy InChI
Affinity DataKi:  1.26E+3nMAssay Description:Fluorescence polarization (FP) data were measured on a microplate reader (Tecan Infinite M1000, Mannedorf, Switzerland) at 27° C. For Kd measurements...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R214GFUS Patent
TargetDisabled homolog 2(Human)
TRUSTEES OF DARTMOUTH COLLEGE

US Patent
LigandPNGBDBM29643((6aS)-6-methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g...)copy SMILEScopy InChI
Affinity DataKi:  1.92E+3nMAssay Description:Fluorescence polarization (FP) data were measured on a microplate reader (Tecan Infinite M1000, Mannedorf, Switzerland) at 27° C. For Kd measurements...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2R214GFUS Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM398054(US10322118, Urea-Based Scaffold Entry 1)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM25737(12-[(adamantan-1-ylcarbamoyl)amino]dodecanoic acid...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant human sEH expressed in insect High Five cells preincubated for 5 mins followed by addition of t-DPPO as substrate measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB18TZPubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM50327827(1-(4-Nitrophenyl)-3-(1-propionylpiperidin-4-yl)ure...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398056(US10322118, Urea-Based Scaffold Entry 4)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398055(US10322118, Urea-Based Scaffold Entry 3)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM50385105(CHEMBL2035874 | US10322118, Entry 8b)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM18864(3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]pr...)copy SMILEScopy InChI
Affinity DataIC50: 4.40E+3nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM18862(2-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]ac...)copy SMILEScopy InChI
Affinity DataIC50: 4.70E+3nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
TargetEpoxide hydrolase 1(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50184992(CHEMBL3823046)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of recombinant human mEH expressed in baculovirus expression system assessed as formation of 6-methoxy-2-naphthaldehyde preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB18TZPubMed
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)copy SMILEScopy InChI
Affinity DataIC50: 7.40E+3nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM50184990(CHEMBL3824249)copy SMILEScopy InChI
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of recombinant human sEH expressed in insect High Five cells preincubated for 5 mins followed by addition of t-DPPO as substrate measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB18TZPubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM50184991(CHEMBL3824048)copy SMILEScopy InChI
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of recombinant human sEH expressed in insect High Five cells preincubated for 5 mins followed by addition of t-DPPO as substrate measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB18TZPubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM50184989(CHEMBL3824213)copy SMILEScopy InChI
Affinity DataIC50: 8.60E+3nMAssay Description:Inhibition of recombinant human sEH expressed in insect High Five cells preincubated for 5 mins followed by addition of t-DPPO as substrate measured ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB18TZPubMed
TargetEpoxide hydrolase 1(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50184989(CHEMBL3824213)copy SMILEScopy InChI
Affinity DataIC50: 1.72E+4nMAssay Description:Inhibition of recombinant human mEH expressed in baculovirus expression system assessed as formation of 6-methoxy-2-naphthaldehyde preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB18TZPubMed
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398043(US10322118, Entry 1)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+4nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398047(US10322118, Entry 5)copy SMILEScopy InChI
Affinity DataIC50: 2.10E+4nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetEpoxide hydrolase 1(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50184990(CHEMBL3824249)copy SMILEScopy InChI
Affinity DataIC50: 2.63E+4nMAssay Description:Inhibition of recombinant human mEH expressed in baculovirus expression system assessed as formation of 6-methoxy-2-naphthaldehyde preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB18TZPubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM398060(US10322118, Urea-Based Scaffold Entry 8)copy SMILEScopy InChI
Affinity DataIC50: 3.33E+4nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM50327827(1-(4-Nitrophenyl)-3-(1-propionylpiperidin-4-yl)ure...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+4nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398046(US10322118, Entry 4)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+4nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetEpoxide hydrolase 1(Homo sapiens (Human))
University of California

Curated by ChEMBL
LigandPNGBDBM50184991(CHEMBL3824048)copy SMILEScopy InChI
Affinity DataIC50: 9.78E+4nMAssay Description:Inhibition of recombinant human mEH expressed in baculovirus expression system assessed as formation of 6-methoxy-2-naphthaldehyde preincubated for 5...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB18TZPubMed
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398045(US10322118, Entry 3)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
AstraZeneca

LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398059(US10322118, Urea-Based Scaffold Entry 7)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398058(US10322118, Urea-Based Scaffold Entry 6)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398057(US10322118, Urea-Based Scaffold Entry 5)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398054(US10322118, Urea-Based Scaffold Entry 1)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM50060966(4-Phenoxy-benzoic acid | CHEMBL107518 | US10322118...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM50334276(4-phenoxyaniline | CHEMBL249550 | US10322118, Entr...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398051(US10322118, Entry 9)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM50115668(3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent
TargetPutative hydrolase(Pseudomonas aeruginosa (strain UCBPP-PA14))
AstraZeneca

LigandPNGBDBM398048(US10322118, Entry 6)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:The first step in characterizing the two compounds identified by high throughput screening was to verify that the inhibition was reproducible using f...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2KW5JC9US Patent