Compile Data Set for Download or QSAR
Found 331 with Last Name = 'mitchell' and Initial = 'dr'
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Teijin Pharma Ltd.

Curated by ChEMBL
LigandPNGBDBM50395262(CHEMBL2163999)copy SMILEScopy InChI
Affinity DataKi:  6.00E+3nMAssay Description:Competitive inhibition of MAPKAP-K2 using KKLNRTLSVA as substrate and [33P]-gamma-ATP by Lineweaver-Burke plot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20K29PXPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427143(1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...)copy SMILEScopy InChI
Affinity DataIC50: 0.490nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427143(1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...)copy SMILEScopy InChI
Affinity DataIC50: 0.490nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427127(1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427127(1-({[(1R)-2-[(4-chloro-2-methanesulfonylphenyl)met...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427195(US10544132, Example 136 | US10981898, Example 137 ...)copy SMILEScopy InChI
Affinity DataIC50: 0.570nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427196(US10544132, Example 137)copy SMILEScopy InChI
Affinity DataIC50: 0.570nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427156(4-{[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[I-hydroxy-...)copy SMILEScopy InChI
Affinity DataIC50: 0.640nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427156(4-{[(1R)-1-(4-chlorophenyl)-7-fluoro-5-[I-hydroxy-...)copy SMILEScopy InChI
Affinity DataIC50: 0.640nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427123(US10544132, Example 70 | US10981898, Example 69)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427122(US10544132, Example 69 | US10981898, Example 70)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427147((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 0.790nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427147((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 0.790nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427098(US10544132, Example 50 | US10981898, Example 62 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM492987(US10981898, Example 98)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427098(US10544132, Example 50 | US10981898, Example 62 | ...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427158((3S)-3-(4-chlorophenyl)-3-[(1R)-1-(4-chlorophenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427139((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427136((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427194(US10544132, Example 135 | US10981898, Example 134 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427193(US10544132, Example 134 | US11236047, Example 135)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427195(US10544132, Example 136 | US10981898, Example 137 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427195(US10544132, Example 136 | US10981898, Example 137 ...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427125(US10544132, Example 72 | US10981898, Example 72 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427125(US10544132, Example 72 | US10981898, Example 72 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427086((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427086((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM492940(US10981898, Example 35 | US11236047, Example 35 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427118((3R)-2-[(4-Chloro-2-methanesulfonylphenyl)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427080(US10544132, Example 35)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427118((3R)-2-[(4-Chloro-2-methanesulfonylphenyl)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427184(US10544132, Example 125 | US10981898, Example 126)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427078(US10544132, Example 33 | US11236047, Example 33 | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427185(US10544132, Example 126)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427081( (3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM492938(US10981898, Example 33)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427081( (3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427124(US10544132, Example 71 | US10981898, Example 71 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427124(US10544132, Example 71 | US10981898, Example 71 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427116((3R)-2-[(4-Chloro-2-methanesulfonylphenyl)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427117((3R)-2-[(4-Chloro-2-methanesulfonylphenyl)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM492977(US10981898, Example 79)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427132(US10544132, Example 79 | US11236047, Example 79 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427098(US10544132, Example 50 | US10981898, Example 62 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427115((3R)-2-[(4-Chloro-2-methanesulfinylphenyl)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetDNA gyrase subunit A/B(Staphylococcus aureus)
Biota Holdings Ltd

Curated by ChEMBL
LigandPNGBDBM50494813(CHEMBL3094348)copy SMILEScopy InChI
Affinity DataIC50: 2.38nMAssay Description:Inhibition of Staphylococcus aureus DNA gyrase ATPase subunit GyrA2/GyrB2 after 60 mins by malachite green staining assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HD7ZMQPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427135(US10544132, Example 82 | US10981898, Example 82 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427135(US10544132, Example 82 | US10981898, Example 82 | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetCellular tumor antigen p53 [1-83]/E3 ubiquitin-protein ligase Mdm2 [1-188](Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM492978(US10981898, Example 81)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2154M5VUS Patent
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
ASTEX THERAPEUTICS LIMITED; CANCER RESEARCH TECHNOLOGY LIMITED

US Patent
LigandPNGBDBM427134((3R)-2-[(4-chloro-2-methanesulfonylphenyl)methyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:The ELISA assay was performed in streptavidin coated plates which were preincubated with 200 μl per well of 1 μg ml−1 biotinylated IP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q27H1N06US Patent
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