Compile Data Set for Download or QSAR
Found 32 with Last Name = 'st laurent' and Initial = 'dr'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50496099(CHEMBL3121151)copy SMILEScopy InChI
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of human ERG by whole cell patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28918V3PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50387084(BMS-790052 | DACLATASVIR)copy SMILEScopy InChI
Affinity DataIC50: 2.92E+4nMAssay Description:Inhibition of human ERG by whole cell patch clamp assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28918V3PubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046342(2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrolidin...)copy SMILEScopy InChI
Affinity DataEC50:  840nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetAnionic trypsin(Bos taurus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)copy SMILEScopy InChI
Affinity DataEC50:  220nMAssay Description:Inhibitory activity against bovine pancreatic trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetAnionic trypsin(Bos taurus)
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)copy SMILEScopy InChI
Affinity DataEC50:  26nMAssay Description:Inhibitory activity against bovine pancreatic trypsin was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046344(1-(3-Oxo-3-phenyl-propionyl)-pyrrolidine-2-carboxy...)copy SMILEScopy InChI
Affinity DataEC50:  590nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046348(1-(4-Oxo-4-pyridin-3-yl-butyryl)-pyrrolidine-2-car...)copy SMILEScopy InChI
Affinity DataEC50:  1.17E+3nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046346(1-(2-Oxo-5-phenyl-pentanoyl)-pyrrolidine-2-carboxy...)copy SMILEScopy InChI
Affinity DataEC50:  880nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)copy SMILEScopy InChI
Affinity DataEC50:  2.35E+3nMAssay Description:Inhibitory activity against human plasmin was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046349(1-(4-Cyclohexyl-butyryl)-pyrrolidine-2-carboxylic ...)copy SMILEScopy InChI
Affinity DataEC50:  5.60E+4nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046347(1-(4-Oxo-4-thiophen-2-yl-butyryl)-pyrrolidine-2-ca...)copy SMILEScopy InChI
Affinity DataEC50:  590nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046350(1-(4-Cyclohexyl-4-oxo-butyryl)-pyrrolidine-2-carbo...)copy SMILEScopy InChI
Affinity DataEC50:  150nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164198(3,9-difluoro-12-(6-fluoromethyl-3,4,5-trihydroxyte...)copy SMILEScopy InChI
Affinity DataEC50:  76.8nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164199(3,9-difluoro-12-(5-fluoro-3,4,5-trihydroxy-6-hydro...)copy SMILEScopy InChI
Affinity DataEC50:  12.8nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164202(2,3,9,10-tetrafluoro-13-(6-fluoromethyl-3,4,5-trih...)copy SMILEScopy InChI
Affinity DataEC50:  240nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50002738copy SMILEScopy InChI
Affinity DataEC50:  704nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164197(3,9-difluoro-12-(5-fluoro-3,4-dihydroxy-6-hydroxym...)copy SMILEScopy InChI
Affinity DataEC50:  17.6nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164196(3,9-difluoro-12-(5-fluoro-3,4-dihydroxy-6-hydroxym...)copy SMILEScopy InChI
Affinity DataEC50:  65.6nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164205(2,3,9,10-tetrafluoro-12-(5-fluoro-3,4-dihydroxy-6-...)copy SMILEScopy InChI
Affinity DataEC50:  120nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164203(2,10-difluoro-12-(5-fluoro-3,4-dihydroxy-6-hydroxy...)copy SMILEScopy InChI
Affinity DataEC50:  32nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164206(3,9-difluoro-13-(6-fluoromethyl-3,4,5-trihydroxyte...)copy SMILEScopy InChI
Affinity DataEC50:  67.2nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164201(12-(6-aminomethyl-5,5-difluoro-3,4-dihydroxytetrah...)copy SMILEScopy InChI
Affinity DataEC50:  8nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164200(2,3,9,10-tetrafluoro-13-(5-fluoro-3,4-dihydroxy-6-...)copy SMILEScopy InChI
Affinity DataEC50:  6.40nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164204(13-(5,5-difluoro-3,4-dihydroxy-6-hydroxymethyltetr...)copy SMILEScopy InChI
Affinity DataEC50:  80nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164207(2,3,9,10-tetrafluoro-12-(6-fluoromethyl-3,4,5-trih...)copy SMILEScopy InChI
Affinity DataEC50:  480nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50164195(12-(6-aminomethyl-5-fluoro-3,4-dihydroxytetrahydro...)copy SMILEScopy InChI
Affinity DataEC50:  11.2nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetDNA topoisomerase 1(Homo sapiens (Human))
The Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50142927(12-(3,4-dihydroxy-6-hydroxymethyl-5-methoxytetrahy...)copy SMILEScopy InChI
Affinity DataEC50:  38.4nMAssay Description:Topoisomerase I activity for single-strand breaks in the DNA substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20G3JP5PubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)copy SMILEScopy InChI
Affinity DataEC50:  50nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)copy SMILEScopy InChI
Affinity DataEC50:  390nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetPlasminogen(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)copy SMILEScopy InChI
Affinity DataEC50:  7.65E+3nMAssay Description:Inhibitory activity against human plasmin was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046345(2-{[2-(1-Formyl-4-guanidino-butylcarbamoyl)-pyrrol...)copy SMILEScopy InChI
Affinity DataEC50:  49nMAssay Description:Concentration required to inhibit thrombin hydrolysis of the chromogenic substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed
TargetProthrombin(Homo sapiens (Human))
Bristol-Myers Squibb Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50046343(1-(4-Oxo-4-phenyl-butyryl)-pyrrolidine-2-carboxyli...)copy SMILEScopy InChI
Affinity DataEC50:  390nMAssay Description:Inhibitory activity against human thrombin was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2JM28Q8PubMed