Compile Data Set for Download or QSAR
Found 236 with Last Name = 'enkvist' and Initial = 'e'
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM109209(VX-689)copy SMILEScopy InChI
Affinity DataKi:  0.0155nM ΔG°:  -62.7kJ/mole IC50: 3.88nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028Q58PubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataKi:  0.136nM ΔG°:  -57.3kJ/mole IC50: 34.2nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028Q58PubMed
TargetAurora kinase A/Targeting protein for Xklp2 [1-43](Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataKi:  1.86nM ΔG°:  -50.7kJ/mole IC50: 1.78E+3nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028Q58PubMed
TargetAurora kinase A/Targeting protein for Xklp2 [1-43](Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM109209(VX-689)copy SMILEScopy InChI
Affinity DataKi:  2.17nM ΔG°:  -50.3kJ/mole IC50: 2.07E+3nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM), and TAMR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028Q58PubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Displacement of 5-TAMRA-labeled ARC-1530 from CK2alpha (unknown origin) (1 to 335 residues) after 15 to 60 mins by luminescence assayMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM109209(VX-689)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM). Subseque...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028Q58PubMed
TargetAurora kinase A(Homo sapiens (Human))
University of Tartu, Ravila 14A, 50411 Tartu (Estonia)

LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 0.690nMT: 2°CAssay Description:Threefold dilution series of inhibitors in assay buffer were prepared in wells of a microtiter plate (final concentration stating from 2uM). Subseque...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2028Q58PubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50311411((R)-2-(6-acetamidohexanamido)-6-amino-N-(6-((R)-1-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of PKBgamma in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29R4PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Institute of Chemistry in Estonia

LigandPNGBDBM27250(6-{[(1S,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 2.41nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27249(ARC-903 | N-[(1R)-4-carbamimidamido-1-{[(1R)-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Displacement of fluorescent-ARC-583/ARC-1042/ARC-1059 from His6-tagged recombinant human ROCK2 by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5P5NPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27249(ARC-903 | N-[(1R)-4-carbamimidamido-1-{[(1R)-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Displacement of fluorescent-ARC-1042 from His6-tagged recombinant human ROCK2 by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5P5NPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27249(ARC-903 | N-[(1R)-4-carbamimidamido-1-{[(1R)-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Displacement of fluorescent-ARC-583/ARC-1042/ARC-1059 from His6-tagged recombinant human ROCK2 by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5P5NPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50311409(CHEMBL1077375 | N-((6R,9R,12R,15R,18R,21R,31R)-1-a...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5P5NPubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50010942(CHEMBL4077554)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of CK2alpha (unknown origin) (1 to 335 residues) using 5-TAMRA-RADDSDDDDD as substrate after 30 mins by fluorescence imaging methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21G0PRWPubMed
LigandPNGBDBM50311410(CHEMBL1077376 | N-((5S,8R,11R,14R,17R,20R,23R,33R)...)copy SMILEScopy InChI
Affinity DataIC50: 4.90nMAssay Description:Inhibition of PKACalpha in presence of 1000 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29R4PubMed
LigandPNGBDBM50199310(2S,3S,4R,5R)-5-6-amino-9H-purin-9-yl)-N-12R,15R,18...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542N79PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Institute of Chemistry in Estonia

LigandPNGBDBM27249(ARC-903 | N-[(1R)-4-carbamimidamido-1-{[(1R)-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMed
LigandPNGBDBM50199310(2S,3S,4R,5R)-5-6-amino-9H-purin-9-yl)-N-12R,15R,18...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542N79PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Institute of Chemistry in Estonia

LigandPNGBDBM27227((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)copy SMILEScopy InChI
Affinity DataIC50: 5.32nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMed
LigandPNGBDBM50311409(CHEMBL1077375 | N-((6R,9R,12R,15R,18R,21R,31R)-1-a...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of PKACalpha in presence of 1000 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29R4PubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27249(ARC-903 | N-[(1R)-4-carbamimidamido-1-{[(1R)-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 6.5nMAssay Description:Displacement of fluorescent-ARC-583/ARC-1042/ARC-1059 from His6-tagged recombinant human p70S6K by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5P5NPubMed
TargetRibosomal protein S6 kinase beta-1(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27249(ARC-903 | N-[(1R)-4-carbamimidamido-1-{[(1R)-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 6.5nMAssay Description:Displacement of fluorescent-ARC-583/ARC-1042/ARC-1059 from His6-tagged recombinant human p70S6K by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5P5NPubMed
LigandPNGBDBM27248(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542N79PubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Institute of Chemistry in Estonia

LigandPNGBDBM27248(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMed
LigandPNGBDBM27248(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMAssay Description:Inhibitory potency towards human cAPK C alpha in the presence of 100uM ATP and 30uM TAMRA-kemptideMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2542N79PubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50382219(CHEMBL2023843)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Displacement of fluorescent-ARC-1063 from His6-tagged recombinant human ROCK2 by luminescence intensity assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5P5NPubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50311409(CHEMBL1077375 | N-((6R,9R,12R,15R,18R,21R,31R)-1-a...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of PKBgamma in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29R4PubMed
LigandPNGBDBM50219803(6-{[(1S,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 12.9nMAssay Description:Inhibition of cAPK Calpha in presence of 0.1 mM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FQ9WBJPubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Institute of Chemistry in Estonia

LigandPNGBDBM27226((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)copy SMILEScopy InChI
Affinity DataIC50: 13.4nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMed
LigandPNGBDBM50311405(CHEMBL1077369 | N-((6R,9R,19R)-1-amino-19-(4-amino...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of PKACalpha in presense of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29R4PubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27227((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)copy SMILEScopy InChI
Affinity DataIC50: 14.6nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50382216(CHEMBL2023839)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Displacement of fluorescent-ARC-1042 from His6-tagged recombinant human ROCK2 by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5P5NPubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50335638(5-(3-Chlorophenylamino)benzo[c][2,6]naphthyridine-...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of CK2alpha (unknown origin) (1 to 335 residues) using 5-TAMRA-RADDSDDDDD as substrate after 30 mins by fluorescence imaging methodMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Institute of Chemistry in Estonia

LigandPNGBDBM27229(6-{[(1S,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 21.1nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27249(ARC-903 | N-[(1R)-4-carbamimidamido-1-{[(1R)-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 30.7nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50382222(CHEMBL2023838)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Displacement of fluorescent-ARC-1042 from His6-tagged recombinant human ROCK2 by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5P5NPubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27248(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-di...)copy SMILEScopy InChI
Affinity DataIC50: 36.9nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM50311410(CHEMBL1077376 | N-((5S,8R,11R,14R,17R,20R,23R,33R)...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of PKBgamma in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29R4PubMed
TargetcGMP-dependent protein kinase 1(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27249(ARC-903 | N-[(1R)-4-carbamimidamido-1-{[(1R)-4-car...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Displacement of fluorescent-ARC-583/ARC-1042/ARC-1059 from His6-tagged recombinant human PKG1alpha by fluorescence anisotropy assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5P5NPubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27250(6-{[(1S,3R,4R)-3-(6-amino-9H-purin-9-yl)-4-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 43.1nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMed
LigandPNGBDBM27225((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Inhibition of PKACalpha in presense of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29R4PubMedMMDB
TargetcAMP-dependent protein kinase catalytic subunit alpha(Mus musculus (mouse))
Institute of Chemistry in Estonia

LigandPNGBDBM27225((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMedMMDB
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
University of Tartu

Curated by ChEMBL
LigandPNGBDBM27226((2R)-6-amino-2-(6-{[(2S,3S,4R,5R)-5-(6-amino-9H-pu...)copy SMILEScopy InChI
Affinity DataIC50: 56.6nMAssay Description:The IC50 values of the inhibitors corresponding to the concentration of the inhibitor decreasing the enzyme activity 50% were measured using fluoresc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX99FQPubMed
LigandPNGBDBM50311407(CHEMBL1077371 | N-((6R,9R,19R)-1-amino-19-(4-amino...)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inhibition of PKACalpha in presense of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM29R4PubMed
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