Compile Data Set for Download or QSAR
Found 318 with Last Name = 'koury' and Initial = 'e'
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35226((S,S)-reboxetine | Reboxetine | Vestra)copy SMILEScopy InChI
Affinity DataKi:  0.300nM ΔG°:  -56.5kJ/molepH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMedDrugBank
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35255(2-Chlor-11-(2-dimethylaminoaethoxy)-dibenzo(b,f)-t...)copy SMILEScopy InChI
Affinity DataKi:  0.5nMAssay Description:Compounds were evaluated the inhibition of [3H] ketanserin binding to membranes from CHO cells, stably transfected with the human 5-HT2A receptor. Da...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)copy SMILEScopy InChI
Affinity DataKi:  0.600nM ΔG°:  -54.8kJ/molepH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMedDrugBank
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)copy SMILEScopy InChI
Affinity DataKi:  2.10nMAssay Description:Inhibition of [3H]nisoxetine binding to human NET expressed in MDCK-Net6 cells by plate scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5V9WPubMedDrugBank
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)copy SMILEScopy InChI
Affinity DataKi:  2.10nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMedDrugBank
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35256((S)-mianserin | Lerivon | MIANSERIN | MIANSERIN (+...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Compounds were evaluated the inhibition of [3H] ketanserin binding to membranes from CHO cells, stably transfected with the human 5-HT2A receptor. Da...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35254(2-methyl-4-(4-methylpiperazin-1-yl)-10H-thieno[2,3...)copy SMILEScopy InChI
Affinity DataKi:  4nMAssay Description:Compounds were evaluated the inhibition of [3H] ketanserin binding to membranes from CHO cells, stably transfected with the human 5-HT2A receptor. Da...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM22417(3-(2-methoxyphenoxy)-N-methyl-3-phenylpropan-1-ami...)copy SMILEScopy InChI
Affinity DataKi:  6nM ΔG°:  -48.8kJ/molepH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35230(indole, 14)copy SMILEScopy InChI
Affinity DataKi:  9nM ΔG°:  -47.8kJ/molepH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35228(CHEMBL21731 | Dibencycladine | Ludiomil | maprotil...)copy SMILEScopy InChI
Affinity DataKi:  12nM ΔG°:  -47.0kJ/molepH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35252(3-(phenylsulfonyl)-1H-indole, 33b)copy SMILEScopy InChI
Affinity DataKi:  13nM ΔG°:  -46.8kJ/mole IC50: 12nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50243500((-)-1-[(1S)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50243503((+)-1-[(1S)-1-(3-Chlorophenyl)-2-piperazin-1-yleth...)copy SMILEScopy InChI
Affinity DataKi:  17nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50243501(1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cycloh...)copy SMILEScopy InChI
Affinity DataKi:  18nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35245(3-(phenylsulfonyl)-1H-indole, 18g)copy SMILEScopy InChI
Affinity DataKi:  19nM IC50: 31nMAssay Description:Compounds were evaluated the inhibition of [3H] ketanserin binding to membranes from CHO cells, stably transfected with the human 5-HT2A receptor. Da...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35251(3-(phenylsulfonyl)-1H-indole, 33a)copy SMILEScopy InChI
Affinity DataKi:  21nM ΔG°:  -45.6kJ/mole IC50: 29nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50010884(1-(2-(dimethylamino)-1-(3-(trifluoromethyl)phenyl)...)copy SMILEScopy InChI
Affinity DataKi:  21nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50005536(42-548 | 5-(4-Chloro-phenyl)-2,5-dihydro-3H-imidaz...)copy SMILEScopy InChI
Affinity DataKi:  22.1nMAssay Description:Inhibition of [3H]WIN-35428 binding to human recombinant DAT expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2CR5V9WPubMedDrugBank
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35244(3-(phenylsulfonyl)-1H-indole, 18f)copy SMILEScopy InChI
Affinity DataKi:  25nM ΔG°:  -45.1kJ/mole IC50: 51nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35247(3-(phenylsulfonyl)-1H-indole, 18i)copy SMILEScopy InChI
Affinity DataKi:  27nM ΔG°:  -44.9kJ/mole IC50: 47nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35232(3-(phenylsulfonyl)-1H-indole, 18b)copy SMILEScopy InChI
Affinity DataKi:  28nM ΔG°:  -44.8kJ/mole IC50: 49nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35248(3-(phenylsulfonyl)-1H-indole, 18j)copy SMILEScopy InChI
Affinity DataKi:  33nM IC50: 69nMAssay Description:Compounds were evaluated the inhibition of [3H] ketanserin binding to membranes from CHO cells, stably transfected with the human 5-HT2A receptor. Da...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50243464((-)-1-[(1R)-1-(3-Chlorophenyl)-2-(dimethylamino)et...)copy SMILEScopy InChI
Affinity DataKi:  41nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35231(3-(phenylsulfonyl)-1H-indole, 18a)copy SMILEScopy InChI
Affinity DataKi:  45nM ΔG°:  -43.6kJ/mole IC50: 80nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243501(1-[1-(3-Chlorophenyl)-2-piperazin-1-ylethyl]cycloh...)copy SMILEScopy InChI
Affinity DataKi:  45nMAssay Description:Displacement of [3H]WIN35428 from human recombinant dopamine transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35250(3-(phenylsulfonyl)-1H-indole, 18l)copy SMILEScopy InChI
Affinity DataKi:  46nM IC50: 57nMAssay Description:Compounds were evaluated the inhibition of [3H] ketanserin binding to membranes from CHO cells, stably transfected with the human 5-HT2A receptor. Da...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50243468(1-[1-(3-Chlorophenyl)-2-(4-methylpiperazin-1-yl)et...)copy SMILEScopy InChI
Affinity DataKi:  46nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50242927((-)-1-{(1S)-2-(4-Methylpiperazin-1-yl)-1-[3-(trifl...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243468(1-[1-(3-Chlorophenyl)-2-(4-methylpiperazin-1-yl)et...)copy SMILEScopy InChI
Affinity DataKi:  53nMAssay Description:Displacement of [3H]WIN35428 from human recombinant dopamine transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50243017(1-{2-Piperazin-1-yl-1-[3-(trifluoromethyl)phenyl]e...)copy SMILEScopy InChI
Affinity DataKi:  58nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35247(3-(phenylsulfonyl)-1H-indole, 18i)copy SMILEScopy InChI
Affinity DataKi:  59nM IC50: 180nMAssay Description:Compounds were evaluated the inhibition of [3H] ketanserin binding to membranes from CHO cells, stably transfected with the human 5-HT2A receptor. Da...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50243016(1-{2-(3-Methylpiperazin-1-yl)-1-[3-(trifluoromethy...)copy SMILEScopy InChI
Affinity DataKi:  61nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35246(3-(phenylsulfonyl)-1H-indole, 18h)copy SMILEScopy InChI
Affinity DataKi:  73nM ΔG°:  -42.4kJ/mole IC50: 128nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243500((-)-1-[(1S)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)copy SMILEScopy InChI
Affinity DataKi:  73nMAssay Description:Displacement of [3H]WIN35428 from human recombinant dopamine transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35242(3-(phenylsulfonyl)-1H-indole, 18d)copy SMILEScopy InChI
Affinity DataKi:  78nM ΔG°:  -42.2kJ/mole IC50: 146nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35249(3-(phenylsulfonyl)-1H-indole, 18k)copy SMILEScopy InChI
Affinity DataKi:  89nM IC50: 92nMAssay Description:Compounds were evaluated the inhibition of [3H] ketanserin binding to membranes from CHO cells, stably transfected with the human 5-HT2A receptor. Da...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50242925(1-{2-(3-Methylpiperazin-1-yl)-1-[3-(trifluorometho...)copy SMILEScopy InChI
Affinity DataKi:  91nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35244(3-(phenylsulfonyl)-1H-indole, 18f)copy SMILEScopy InChI
Affinity DataKi:  110nM IC50: 650nMAssay Description:Compounds were evaluated the inhibition of [3H] ketanserin binding to membranes from CHO cells, stably transfected with the human 5-HT2A receptor. Da...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35246(3-(phenylsulfonyl)-1H-indole, 18h)copy SMILEScopy InChI
Affinity DataKi:  117nM IC50: 258nMAssay Description:Compounds were evaluated the inhibition of [3H] ketanserin binding to membranes from CHO cells, stably transfected with the human 5-HT2A receptor. Da...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50243015((+)-1-{(1S)-2-Piperazin-1-yl-1-[3-(trifluoromethox...)copy SMILEScopy InChI
Affinity DataKi:  117nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35249(3-(phenylsulfonyl)-1H-indole, 18k)copy SMILEScopy InChI
Affinity DataKi:  125nM ΔG°:  -41.0kJ/mole IC50: 116nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50010860(1-(1-(2-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)copy SMILEScopy InChI
Affinity DataKi:  125nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243503((+)-1-[(1S)-1-(3-Chlorophenyl)-2-piperazin-1-yleth...)copy SMILEScopy InChI
Affinity DataKi:  135nMAssay Description:Displacement of [3H]WIN35428 from human recombinant dopamine transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50243013(1-{2-Piperazin-1-yl-1-[3-(trifluoromethoxy)phenyl]...)copy SMILEScopy InChI
Affinity DataKi:  140nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50010858(1-(1-(3-chlorophenyl)-2-(dimethylamino)ethyl)cyclo...)copy SMILEScopy InChI
Affinity DataKi:  149nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50243469((+)-1-[(1R)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)copy SMILEScopy InChI
Affinity DataKi:  187nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35248(3-(phenylsulfonyl)-1H-indole, 18j)copy SMILEScopy InChI
Affinity DataKi:  208nM ΔG°:  -39.7kJ/mole IC50: 221nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated the inhibition of [3H] nisoxetine binding to MDCK-Net6 cells, stably transfected with the human norepinephrine transporter (...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM50243502((-)-1-[(1R)-1-(3-Chlorophenyl)-2-piperazin-1-yleth...)copy SMILEScopy InChI
Affinity DataKi:  214nMAssay Description:Displacement of [3H]nisoxetine from human norepinephrine transporter expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35232(3-(phenylsulfonyl)-1H-indole, 18b)copy SMILEScopy InChI
Affinity DataKi:  222nM IC50: 832nMAssay Description:Compounds were evaluated the inhibition of [3H] ketanserin binding to membranes from CHO cells, stably transfected with the human 5-HT2A receptor. Da...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26Q1VK2PubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50243469((+)-1-[(1R)-1-(3-Chlorophenyl)-2-(4-methylpiperazi...)copy SMILEScopy InChI
Affinity DataKi:  235nMAssay Description:Displacement of [3H]WIN35428 from human recombinant dopamine transporter expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TB16PBPubMed
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