Compile Data Set for Download or QSAR
Found 290 with Last Name = 'levin' and Initial = 'e'
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442922(CHEMBL3086984)copy SMILEScopy InChI
Affinity DataKi:  0.0310nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442927(CHEMBL3086994)copy SMILEScopy InChI
Affinity DataKi:  0.0320nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442921(CHEMBL3086985)copy SMILEScopy InChI
Affinity DataKi:  0.0430nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442924(CHEMBL3086982)copy SMILEScopy InChI
Affinity DataKi:  0.0460nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442930(CHEMBL3086991)copy SMILEScopy InChI
Affinity DataKi:  0.0490nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442926(CHEMBL3086995)copy SMILEScopy InChI
Affinity DataKi:  0.0500nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.0620nM ΔG°:  -54.2kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.0620nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM397477(US9993465, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.0620nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442928(CHEMBL3086993)copy SMILEScopy InChI
Affinity DataKi:  0.0720nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442920(CHEMBL3086986)copy SMILEScopy InChI
Affinity DataKi:  0.0760nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442929(CHEMBL3086992)copy SMILEScopy InChI
Affinity DataKi:  0.0830nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.0870nM ΔG°:  -53.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397477(US9993465, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.0870nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442923(CHEMBL3086983)copy SMILEScopy InChI
Affinity DataKi:  0.0930nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442932(CHEMBL3086989)copy SMILEScopy InChI
Affinity DataKi:  0.110nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM221048(US9284322, varenicline | US9303017, Varenicline)copy SMILEScopy InChI
Affinity DataKi:  0.120nM ΔG°:  -52.6kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)copy SMILEScopy InChI
Affinity DataKi:  0.120nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)copy SMILEScopy InChI
Affinity DataKi:  0.130nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50072110(3-((S)-1-Azetidin-2-ylmethoxy)-5-phenyl-pyridine |...)copy SMILEScopy InChI
Affinity DataKi:  0.140nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442925(CHEMBL3086996)copy SMILEScopy InChI
Affinity DataKi:  0.260nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM397477(US9993465, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.380nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM50382474(CHEMBL2024096 | US9303017, Sazetidine-A)copy SMILEScopy InChI
Affinity DataKi:  0.380nM ΔG°:  -50.0kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM221048(US9284322, varenicline | US9303017, Varenicline)copy SMILEScopy InChI
Affinity DataKi:  0.480nM ΔG°:  -49.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)copy SMILEScopy InChI
Affinity DataKi:  0.480nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
TargetSteroid hormone receptor ERR2(Homo sapiens (Human))
GTx, Inc.; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

US Patent
LigandPNGBDBM312140(6,8-dihydroxy-2-(4-hydroxyphenyl)-4-(4-methoxyphen...)copy SMILEScopy InChI
Affinity DataKi:  0.480nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25FRUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50442931(CHEMBL3086990)copy SMILEScopy InChI
Affinity DataKi:  1.20nMAssay Description:Displacement of [3H]epibatidine from human alpha4beta2 nAChR after 4 hrs by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JW8GBVPubMed
TargetSteroid hormone receptor ERR2(Homo sapiens (Human))
GTx, Inc.; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

US Patent
LigandPNGBDBM312151((E)-6,8-dihydroxy-2-(4-hydroxyphenyl)-4-(prop-1-en...)copy SMILEScopy InChI
Affinity DataKi:  1.66nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25FRUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM50166908(5,8,14-triazatetracyclo[10.3.1.02,11.04,9]hexadeca...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-3/beta-2(Rattus norvegicus (Rat))
BioCryst Pharmaceuticals

LigandPNGBDBM221048(US9284322, varenicline | US9303017, Varenicline)copy SMILEScopy InChI
Affinity DataKi:  2.5nM ΔG°:  -45.6kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
TargetSteroid hormone receptor ERR2(Homo sapiens (Human))
GTx, Inc.; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

US Patent
LigandPNGBDBM312096(4-bromo-6,8-dihydroxy-2-(4-hydroxyphenyl)isoquinol...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25FRUS Patent
TargetSteroid hormone receptor ERR2(Homo sapiens (Human))
GTx, Inc.; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

US Patent
LigandPNGBDBM312133(US9604931, 12z)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25FRUS Patent
TargetSteroid hormone receptor ERR2(Homo sapiens (Human))
GTx, Inc.; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

US Patent
LigandPNGBDBM312149(6,8-dihydroxy-2-(4-hydroxyphenyl)-4-(4-methoxyphen...)copy SMILEScopy InChI
Affinity DataKi:  3.03nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25FRUS Patent
TargetSteroid hormone receptor ERR2(Homo sapiens (Human))
GTx, Inc.; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

US Patent
LigandPNGBDBM312139(2-(3-fluoro-4-hydroxyphenyl)-6,8-dihydroxy-4-vinyl...)copy SMILEScopy InChI
Affinity DataKi:  3.96nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25FRUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50428080(CHEMBL2323571 | US9303017, (S)-22, YL-1-231)copy SMILEScopy InChI
Affinity DataKi:  4.20nM ΔG°:  -44.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50428081(CHEMBL2323570 | US9303017, (S)-17)copy SMILEScopy InChI
Affinity DataKi:  4.30nM ΔG°:  -44.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM397483(US9993465, (S)-17)copy SMILEScopy InChI
Affinity DataKi:  4.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50428081(CHEMBL2323570 | US9303017, (S)-17)copy SMILEScopy InChI
Affinity DataKi:  4.30nM ΔG°:  -44.4kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50428086(CHEMBL2323572 | US9303017, (S)-21, YL-1-235)copy SMILEScopy InChI
Affinity DataKi:  4.70nM ΔG°:  -44.2kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50428080(CHEMBL2323571 | US9303017, (S)-22, YL-1-231)copy SMILEScopy InChI
Affinity DataKi:  5.10nM ΔG°:  -44.0kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM397484(US9993465, (S)-22)copy SMILEScopy InChI
Affinity DataKi:  5.10nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM50428086(CHEMBL2323572 | US9303017, (S)-21, YL-1-235)copy SMILEScopy InChI
Affinity DataKi:  5.30nM ΔG°:  -43.9kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM50428081(CHEMBL2323570 | US9303017, (S)-17)copy SMILEScopy InChI
Affinity DataKi:  5.30nM ΔG°:  -43.9kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397483(US9993465, (S)-17)copy SMILEScopy InChI
Affinity DataKi:  5.30nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
Georgetown University

Curated by ChEMBL
LigandPNGBDBM397485(US9993465, (S)-21)copy SMILEScopy InChI
Affinity DataKi:  5.30nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetSteroid hormone receptor ERR2(Homo sapiens (Human))
GTx, Inc.; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

US Patent
LigandPNGBDBM312134(4-bromo-6-methoxy-2-(4-methoxyphenyl)-1-oxo-1,2-di...)copy SMILEScopy InChI
Affinity DataKi:  6nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25FRUS Patent
TargetSteroid hormone receptor ERR2(Homo sapiens (Human))
GTx, Inc.; THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

US Patent
LigandPNGBDBM312135(6,8-dihydroxy-2-(4-hydroxyphenyl)-1-oxo-1,2-dihydr...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Estrogen receptor (ERβ) binding affinity of the NRBAs was also determined using an in vitro competitive radioligand-binding assay with [3H]-estr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23N25FRUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Rattus norvegicus (Rat))
Georgetown University; Duke University

US Patent
LigandPNGBDBM50428086(CHEMBL2323572 | US9303017, (S)-21, YL-1-235)copy SMILEScopy InChI
Affinity DataKi:  8.60nM ΔG°:  -42.8kJ/molepH: 7.4 T: 2°CAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm^2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris....More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q25X27SFUS Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397485(US9993465, (S)-21)copy SMILEScopy InChI
Affinity DataKi:  8.60nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
TargetNeuronal acetylcholine receptor subunit alpha-2/beta-2(Homo sapiens (Human))
BioCryst Pharmaceuticals

LigandPNGBDBM397484(US9993465, (S)-22)copy SMILEScopy InChI
Affinity DataKi:  8.70nMAssay Description:Briefly, cultured cells at >80% confluence were removed from their flasks (80 cm2) with a disposable cell scraper and placed in 10 mL of 50 mM Tris.H...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q24T6MQ8US Patent
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