Compile Data Set for Download or QSAR
Found 166 with Last Name = 'muise' and Initial = 'e'
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128419(1-{5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-...)copy SMILEScopy InChI
Affinity DataKi:  1.18E+3nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50409702(CHEMBL2112296)copy SMILEScopy InChI
Affinity DataKi:  2.10E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50409699(CHEMBL2112294)copy SMILEScopy InChI
Affinity DataKi:  2.24E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128424(2-{5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-...)copy SMILEScopy InChI
Affinity DataKi:  2.27E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128424(2-{5-[1-(3,4-Bis-difluoromethoxy-phenyl)-2-(1-oxy-...)copy SMILEScopy InChI
Affinity DataKi:  2.27E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128686(2-{5-[1-(3-Cyclobutoxy-4-difluoromethoxy-phenyl)-2...)copy SMILEScopy InChI
Affinity DataKi:  2.50E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128689(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  2.64E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128689(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  2.64E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50409700(CHEMBL2112295)copy SMILEScopy InChI
Affinity DataKi:  3.81E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50409701(CHEMBL383762)copy SMILEScopy InChI
Affinity DataKi:  3.90E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128683(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  4.22E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128683(2-{5-[1-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-...)copy SMILEScopy InChI
Affinity DataKi:  4.47E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128692(5-{2-(3-Cyclopropoxy-4-difluoromethoxy-phenyl)-2-[...)copy SMILEScopy InChI
Affinity DataKi:  5.59E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128685(2-{5-[1-(3-Cyclobutoxy-4-difluoromethoxy-phenyl)-2...)copy SMILEScopy InChI
Affinity DataKi:  5.84E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)copy SMILEScopy InChI
Affinity DataKi:  6.14E+4nMAssay Description:In vitro displacement of [35S]-MK- 499 from HEK 293 cells stably transfected with hERG voltage-gated potassium channel subunit Kv11.1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274028(CHEMBL499477 | N-(3,5-dichloropyridin-4-yl)-1-(3-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.0600nMAssay Description:Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X57M1PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174030((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)copy SMILEScopy InChI
Affinity DataIC50: 0.0700nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174030((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)copy SMILEScopy InChI
Affinity DataIC50: 0.160nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274031(1-(3'-Acetyl-biphenyl-3-yl)-4-oxo-1,4-dihydro-[1,8...)copy SMILEScopy InChI
Affinity DataIC50: 0.170nMAssay Description:Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X57M1PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174025(6-isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.190nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174028((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174028((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174030((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174028((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174023((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174025(6-isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174018((E)-N-isopropyl-3-(3-(6-isopropylquinolin-8-yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174031((Z)-2-(4-(2-(3-(6-isopropylquinolin-8-yl)phenyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174013((E)-3-(3-(6-isopropylquinolin-8-yl)phenyl)-2-(4-(m...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174013((E)-3-(3-(6-isopropylquinolin-8-yl)phenyl)-2-(4-(m...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174029((E)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174018((E)-N-isopropyl-3-(3-(6-isopropylquinolin-8-yl)phe...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274188(1-(4'-Acetyl-biphenyl-3-yl)-4-oxo-1,4-dihydro-[1,8...)copy SMILEScopy InChI
Affinity DataIC50: 0.340nMAssay Description:Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X57M1PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274789(1-(3'-Acetyl-biphenyl-3-yl)-4-oxo-1,4-dihydro-[1,8...)copy SMILEScopy InChI
Affinity DataIC50: 0.370nMAssay Description:Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X57M1PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174028((E)-6-isopropyl-8-(3-(2-(5-methylpyridin-2-yl)-2-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174021((Z)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174020((S)-(+)-3-{2-[(3-Cyclopropyloxy-4-difluromethoxy)-...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174031((Z)-2-(4-(2-(3-(6-isopropylquinolin-8-yl)phenyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50274027(1-(4-chlorophenyl)-N-(3,5-dichloropyridin-4-yl)-4-...)copy SMILEScopy InChI
Affinity DataIC50: 0.450nMAssay Description:Intrinsic inhibition of GST-fused human PDE4A expressed in SF9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X57M1PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174025(6-isopropyl-8-(3-(2-(4-(methylsulfonyl)phenyl)-2-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.470nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174015((E)-N-isopropyl-2-(4-(methylsulfonyl)phenyl)-3-(3-...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174031((Z)-2-(4-(2-(3-(6-isopropylquinolin-8-yl)phenyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4C(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174031((Z)-2-(4-(2-(3-(6-isopropylquinolin-8-yl)phenyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against PDE4CMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174013((E)-3-(3-(6-isopropylquinolin-8-yl)phenyl)-2-(4-(m...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4B(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174022((E)-8-(3-(2-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(4-(...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against PDE4BMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50128685(2-{5-[1-(3-Cyclobutoxy-4-difluoromethoxy-phenyl)-2...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:In vitro inhibitory activity was determined against human Phosphodiesterase 4 isoform using a construct representing the common region of spliced var...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24X5756PubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A(Homo sapiens (Human))
Merck Frosst Center for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174023((E)-6-isopropyl-8-(3-(2-(3-methyl-1,2,4-oxadiazol-...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against PDE4AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4D(Homo sapiens (Human))
Merck Frosst Centre for Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50174021((Z)-3-(3-(6-(2-cyanopropan-2-yl)quinolin-8-yl)phen...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibitory activity against PDE4DMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B56KHGPubMed
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