Compile Data Set for Download or QSAR
Found 350 with Last Name = 'hansson' and Initial = 'el'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50445876(CHEMBL3105692)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369033(CHEMBL4167096)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50368995(CHEMBL4159819)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM493606(US10988445, Example 202)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19BGPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50502387(CHEMBL4458320)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50445876(CHEMBL3105692)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inverse agonist activity at RORgammat in human TH17 cells assessed as inhibition of IL17 release incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369079(CHEMBL4176887)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50368993(CHEMBL4163193)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50368990(CHEMBL4163215)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369036(CHEMBL4173908)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369077(CHEMBL4168496)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50445877(CHEMBL3105681)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM493605(US10988445, Example 201)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19BGPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50368987(CHEMBL4166982)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369042(CHEMBL4160227)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50368995(CHEMBL4159819)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inverse agonist activity at RORgammat in human TH17 cells assessed as inhibition of IL17 release incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM493607(US10988445, Example 203)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19BGPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50502392(CHEMBL4445119)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736V64PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369034(CHEMBL4174976)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369043(CHEMBL4168454)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50502386(CHEMBL4520758)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736V64PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369047(CHEMBL4175680)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369046(CHEMBL4167788)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369044(CHEMBL4159082)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369038(CHEMBL4173467)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369045(CHEMBL4159395)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50368991(CHEMBL4176822)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
TargetCytochrome P450 2D6(Homo sapiens (Human))TBA
LigandPNGBDBM493697(US10988445, Example 500)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19BGPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369043(CHEMBL4168454)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inverse agonist activity at biotinylated HN-Avi-MBP-TCS-human RORgammat (258 to 518 residues) assessed as inhibition of biotinylated SRC-1 peptide NC...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50445877(CHEMBL3105681)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inverse agonist activity at biotinylated HN-Avi-MBP-TCS-human RORgammat (258 to 518 residues) assessed as inhibition of biotinylated SRC-1 peptide NC...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369024(CHEMBL4170472)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inverse agonist activity at RORgammat in human TH17 cells assessed as inhibition of IL17 release incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50445876(CHEMBL3105692)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inverse agonist activity at biotinylated HN-Avi-MBP-TCS-human RORgammat (258 to 518 residues) assessed as inhibition of biotinylated SRC-1 peptide NC...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369042(CHEMBL4160227)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inverse agonist activity at RORgammat in human TH17 cells assessed as inhibition of IL17 release incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50502407(CHEMBL4549060 | US11084784, Example 13)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736V64PubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50502387(CHEMBL4458320)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Displacement of tritiated 2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from mouse HN-AVI-GST-TCS-RORC (256 to 51...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50502404(CHEMBL4435215)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736V64PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50368990(CHEMBL4163215)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inverse agonist activity at RORgammat in human TH17 cells assessed as inhibition of IL17 release incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369075(CHEMBL4165060)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369042(CHEMBL4160227)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inverse agonist activity at biotinylated HN-Avi-MBP-TCS-human RORgammat (258 to 518 residues) assessed as inhibition of biotinylated SRC-1 peptide NC...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM493606(US10988445, Example 202)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at human RORC2 assessed as inhibition of SRC1-derived coactivator peptide by TR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22Z19BGPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369027(CHEMBL4161696)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Displacement of [3H]-2-(4-(ethylsulfonyl)phenyl)-N-(4-(2-(methoxymethyl)phenyl)thiophen-2-yl)acetamide from purified N-(HN)6-GST-TCS-human RORgammat ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369045(CHEMBL4159395)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at biotinylated HN-Avi-MBP-TCS-human RORgammat (258 to 518 residues) assessed as inhibition of biotinylated SRC-1 peptide NC...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50368987(CHEMBL4166982)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at biotinylated HN-Avi-MBP-TCS-human RORgammat (258 to 518 residues) assessed as inhibition of biotinylated SRC-1 peptide NC...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369038(CHEMBL4173467)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at biotinylated HN-Avi-MBP-TCS-human RORgammat (258 to 518 residues) assessed as inhibition of biotinylated SRC-1 peptide NC...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369033(CHEMBL4167096)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at biotinylated HN-Avi-MBP-TCS-human RORgammat (258 to 518 residues) assessed as inhibition of biotinylated SRC-1 peptide NC...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50368990(CHEMBL4163215)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at biotinylated HN-Avi-MBP-TCS-human RORgammat (258 to 518 residues) assessed as inhibition of biotinylated SRC-1 peptide NC...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50502393(CHEMBL4562895)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL-17A secretion incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50502393(CHEMBL4562895)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator measu...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50369079(CHEMBL4176887)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at RORgammat in human TH17 cells assessed as inhibition of IL17 release incubated for 4 days by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0WFQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50502388(CHEMBL4525318 | US11084784, Example 1)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inverse agonist activity at human biotinylated HN-Avi-MBPS-TCS-RORC2 (258 to 518 residues) assessed as recruitment of SRC-1-derived coactivator measu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2736V64PubMed
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