Compile Data Set for Download or QSAR
Found 546 with Last Name = 'preugschat' and Initial = 'f'
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8143(N-[3-bromo-5-(trifluoromethyl)phenyl]-4-{pyrazolo[...)copy SMILEScopy InChI
Affinity DataKi:  0.300nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086433(CHEMBL3426034)copy SMILEScopy InChI
Affinity DataKi:  0.300nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086438(CHEMBL3426039)copy SMILEScopy InChI
Affinity DataKi:  0.450nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086434(CHEMBL3426035)copy SMILEScopy InChI
Affinity DataKi:  0.700nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8138(N-(3,4-dihydro-2H-1,5-benzodioxepin-7-yl)-4-{pyraz...)copy SMILEScopy InChI
Affinity DataKi:  1nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8145(N-(3,5-dichlorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataKi:  1nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8146(N-(3,5-dimethylphenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataKi:  1nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8136(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{pyrazolo[1...)copy SMILEScopy InChI
Affinity DataKi:  1nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8144(N-(3,5-difluorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8130(N-(4-nitrophenyl)-4-{pyrazolo[1,5-a]pyridazin-3-yl...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8129(4-[(4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-y...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8171(N-(2,3-dihydro-1,4-benzodioxin-6-yl)-4-{2-phenylpy...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8135(N-(2H-1,3-benzodioxol-5-yl)-4-{pyrazolo[1,5-a]pyri...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8142(N-[3-methoxy-5-(trifluoromethyl)phenyl]-4-{pyrazol...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8140(N-[4-chloro-3-(trifluoromethyl)phenyl]-4-{pyrazolo...)copy SMILEScopy InChI
Affinity DataKi:  2nM IC50: 10nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086425(CHEMBL3426030)copy SMILEScopy InChI
Affinity DataKi:  14nMAssay Description:Inhibition of wild type fully glycosylated human recombinant CD38-catalyzed NAD hydrolysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086336(CHEMBL3426065)copy SMILES
Affinity DataIC50: 0.180nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086432(CHEMBL3426033)copy SMILEScopy InChI
Affinity DataIC50: 0.620nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086436(CHEMBL3426037)copy SMILEScopy InChI
Affinity DataIC50: 0.650nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086334(CHEMBL3426067)copy SMILEScopy InChI
Affinity DataIC50: 0.780nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086337(CHEMBL3426064)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8129(4-[(4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidin-2-y...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8139(N-(3,4-dichlorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8144(N-(3,5-difluorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086350(CHEMBL3426058)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086335(CHEMBL3426066)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086431(CHEMBL3426032)copy SMILES
Affinity DataIC50: 1.30nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086438(CHEMBL3426039)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086336(CHEMBL3426065)copy SMILES
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086434(CHEMBL3426035)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086437(CHEMBL3426038)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086433(CHEMBL3426034)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8128(N-(3-methoxyphenyl)-4-{pyrazolo[1,5-a]pyridazin-3-...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8137(N-(3,4-difluorophenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataIC50: 2nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086439(CHEMBL3426040)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8688((1E)-1-[(4-methanesulfonylphenyl)methylidene]-2-[1...)copy SMILEScopy InChI
Affinity DataIC50: 2.51nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9GF5PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8686(4-[(1E)-{2-[1-(3-methoxyphenyl)-1H-pyrazolo[3,4-d]...)copy SMILEScopy InChI
Affinity DataIC50: 2.51nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9GF5PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8146(N-(3,5-dimethylphenyl)-4-{pyrazolo[1,5-a]pyridazin...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8674(4-{4-[(2E)-2-(pyridin-4-ylmethylidene)hydrazin-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 3.16nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9GF5PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086337(CHEMBL3426064)copy SMILEScopy InChI
Affinity DataIC50: 3.40nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086436(CHEMBL3426037)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086432(CHEMBL3426033)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8695(ethyl({4-[(1E)-{2-[1-(3-methoxyphenyl)-1H-pyrazolo...)copy SMILEScopy InChI
Affinity DataIC50: 3.98nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9GF5PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8687((1E)-1-[(3-methanesulfonylphenyl)methylidene]-2-[1...)copy SMILEScopy InChI
Affinity DataIC50: 3.98nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9GF5PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086351(CHEMBL3426057)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086355(CHEMBL3426053)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086424(CHEMBL3426029)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:Inhibition of mouse recombinant CD38 extracellular domain expressed in CHO CGE cells assessed as NAD hydrolysis by fluorescence plate reader analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50086335(CHEMBL3426066)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human CD38 extracellular domain expressed in Pichia pastoris assessed as NAD hydrolysis by colorimetric-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2NV9M00PubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8126(N-phenyl-4-{pyrazolo[1,5-a]pyridazin-3-yl}pyrimidi...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-32P] ATP. Af...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VM49HJPubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
GlaxoSmithKline

LigandPNGBDBM8540(4-[(1E)-{2-[3-(3-methoxyphenyl)-1H-pyrazolo[4,3-d]...)copy SMILEScopy InChI
Affinity DataIC50: 5.01nMpH: 7.2 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzyme and substrate in the presence 2.5 uM ATP/ [gamma-33P] ATP. Af...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25X274XPubMed
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