Compile Data Set for Download or QSAR
Found 228 with Last Name = 'sugawara' and Initial = 'f'
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)copy SMILEScopy InChI
Affinity DataKi:  3.75E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37BHPubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM50109030(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)copy SMILEScopy InChI
Affinity DataKi:  4.70E+3nMAssay Description:Inhibition constant of the compound was determined at a concentration of 5 microM on rat DNA polymerase beta as a function of template primer doseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K936TCPubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM50448689(CHEMBL3127730)copy SMILEScopy InChI
Affinity DataKi:  5.50E+3nMAssay Description:Competitive inhibition of recombinant rat DNA polymerase beta using poly(dA)/oligo(dT)18 as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22V2HMWPubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM50109030(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)copy SMILEScopy InChI
Affinity DataKi:  6.60E+3nMAssay Description:Inhibition constant of the compound was determined at a concentration of 10 microM on rat DNA polymerase beta as a function of nucleotide substrate c...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K936TCPubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)copy SMILEScopy InChI
Affinity DataKi:  7.84E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37BHPubMed
TargetDNA polymerase kappa(Homo sapiens (Human))
Science University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)copy SMILEScopy InChI
Affinity DataKi:  9.85E+3nMAssay Description:Competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using dTTP as substrate by Dixon plot analy...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T154NGPubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)copy SMILEScopy InChI
Affinity DataKi:  1.12E+4nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37BHPubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM50448689(CHEMBL3127730)copy SMILEScopy InChI
Affinity DataKi:  1.16E+4nMAssay Description:Noncompetitive inhibition of recombinant rat DNA polymerase beta using dTTP as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22V2HMWPubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM50109029(4-{10,13-Dimethyl-3-[3-(6-{6-[5-(2-oxo-hexahydro-t...)copy SMILEScopy InChI
Affinity DataKi:  1.28E+4nMAssay Description:Inhibition constant of the compound was determined at a concentration of 5 microM on rat DNA polymerase beta as a function of template primer doseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K936TCPubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)copy SMILEScopy InChI
Affinity DataKi:  1.38E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37BHPubMed
TargetDNA polymerase kappa(Homo sapiens (Human))
Science University of Tokyo

Curated by ChEMBL
LigandPNGBDBM50379292(CHEMBL2011646)copy SMILEScopy InChI
Affinity DataKi:  1.81E+4nMAssay Description:Non-competitive inhibition of human C-terminal-His6-tagged DNA polymerase kappa expressed in Escherichia coli using ploy(dA)/oligo(dT)18 as substrate...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T154NGPubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)copy SMILEScopy InChI
Affinity DataKi:  1.85E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37BHPubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM50109029(4-{10,13-Dimethyl-3-[3-(6-{6-[5-(2-oxo-hexahydro-t...)copy SMILEScopy InChI
Affinity DataKi:  2.01E+4nMAssay Description:Inhibition constant of the compound was determined at a concentration of 10 microM on rat DNA polymerase beta as a function of template primer doseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K936TCPubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)copy SMILEScopy InChI
Affinity DataKi:  2.79E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37BHPubMed
LigandPNGBDBM50223758(CHEMBL58925)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223748(CHEMBL406322)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223740(CHEMBL431679)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223752(CHEMBL117978)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223762(CHEMBL417588)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223756(CHEMBL333710)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223759(CHEMBL118469)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223754(CHEMBL332885)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223738(CHEMBL118450)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223737(CHEMBL115852)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33388(dehydroaltenusin derivative, 16)copy SMILEScopy InChI
Affinity DataIC50: 60nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348HQKPubMed
LigandPNGBDBM50223757(CHEMBL291976)copy SMILEScopy InChI
Affinity DataIC50: 71nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223761(CHEMBL421236)copy SMILEScopy InChI
Affinity DataIC50: 76nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223736(CHEMBL119657)copy SMILEScopy InChI
Affinity DataIC50: 86nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33387(dehydroaltenusin derivative, 15)copy SMILEScopy InChI
Affinity DataIC50: 90nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348HQKPubMed
LigandPNGBDBM50223753(CHEMBL119059)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223749(CHEMBL332977)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33386(dehydroaltenusin derivative, 14)copy SMILEScopy InChI
Affinity DataIC50: 180nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348HQKPubMed
LigandPNGBDBM50223750(CHEMBL119731)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223739(CHEMBL117056)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33389(dehydroaltenusin derivative, 20)copy SMILEScopy InChI
Affinity DataIC50: 240nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348HQKPubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33384(dehydroaltenusin)copy SMILEScopy InChI
Affinity DataIC50: 680nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348HQKPubMed
LigandPNGBDBM50223741(CHEMBL333173)copy SMILEScopy InChI
Affinity DataIC50: 720nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
TargetDNA polymerase alpha subunit B(Bos taurus (bovine))
Kyoto Prefectural University

LigandPNGBDBM33385(desmethyldehydroaltenusin, 2)copy SMILEScopy InChI
Affinity DataIC50: 890nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348HQKPubMed
LigandPNGBDBM50223751(CHEMBL119353)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223760(CHEMBL332071)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
TargetDNA nucleotidylexotransferase(Homo sapiens (Human))
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM50143524((3aR,4R,7R,7aS)-3,5-Dihexadecyl-3a,4,7,7a-tetrahyd...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibitory activity of the compound against human terminal deoxynucleotidyltransferaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W095C3PubMed
LigandPNGBDBM50223764(CHEMBL119757)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223765(CHEMBL420538)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223755(CHEMBL118108)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
LigandPNGBDBM50223763(CHEMBL261984)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human gamma-secretase activityMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q20K2BR7PubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center for Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibitory concentration against human DNA polymerase alpha incubated with 0.05 unitsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37BHPubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM50109030(4-(3-Hydroxy-10,13-dimethyl-hexadecahydro-cyclopen...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory effect of the compound on the activity of rat DNA polymerase beta was determined by inhibitory dose curvesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K936TCPubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM33388(dehydroaltenusin derivative, 16)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMpH: 7.5 T: 2°CAssay Description:For the DNA polymerase reaction, the dehydroaltenusin derivative was dissolved in dimethyl sulfoxide (DMSO) at various concentrations and sonicated f...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348HQKPubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM50153117((S)-4-((5R,10R,13R,17R)-3-Hydroxy-5,10,13-trimethy...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibitory concentration against rat DNA polymerase beta incubated with 0.05 unitsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RN37BHPubMed
TargetDNA polymerase beta(Rattus norvegicus)
Tokyo University of Science

Curated by ChEMBL
LigandPNGBDBM50375301(CHEMBL260980)copy SMILEScopy InChI
Affinity DataIC50: 1.19E+4nMAssay Description:Inhibition of rat DNA polymerase betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2J67HSTPubMed
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