Compile Data Set for Download or QSAR
Found 131 with Last Name = 'migliaccio' and Initial = 'g'
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162106(1-Cyclohexyl-2-(2-fluoro-4-hydroxy-phenyl)-1H-benz...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162110(1-Cyclohexyl-2-(4-hydroxy-phenyl)-1H-benzoimidazol...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162109(3-Cyclohexyl-2-(4-hydroxy-phenyl)-1H-indole-6-carb...)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162099(2-(4-Benzyloxy-phenyl)-3-cyclohexyl-1-dimethylcarb...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50158838(2-{4-[2-(4-chlorophenyl)-5-(4-hydroxyhexahydro-1-p...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibitory concentration against RNA dependent RNA polymerase nonstructural protein 5B of hepatitis C virusMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169942(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-methanesu...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169930(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(cyclopropylme...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169922(3-Cyclohexyl-1-[2-(4-diethylamino-piperidin-1-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169906(3-Cyclohexyl-1-[2-(2-diethylaminomethyl-morpholin-...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169911(3-Cyclohexyl-1-[2-(2-diethylaminomethyl-morpholin-...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35554(thiophene scaffold, 21)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169899(3-Cyclohexyl-1-[2-(4-dimethylamino-piperidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169904(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-diethylam...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibitory activity against hepatitis C virus NS5B polymerase enzyme; Range=6-9 nMMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169903(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(isopropyl-met...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162105(3-Cyclohexyl-1-(2-morpholin-4-yl-2-oxo-ethyl)-2-p-...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169915(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(1,1-dioxo-1...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169931(2-(4-Chloro-phenyl)-3-cyclohexyl-1-{[methyl-(1-met...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169920(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-methyl-pi...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169919(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[2-(4-dimethyla...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35570(1H-benzo[de]isoquinoline-1,3(2H)-dione, 19)copy SMILEScopy InChI
Affinity DataIC50: 14nM EC50:  2.20E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162104(2-(4-Chloro-phenyl)-3-cyclohexyl-1-dimethylcarbamo...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibitory concentration against NS5B polymerase of Hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetGenome polyprotein [2420-2989,M2833T,R2963Q](Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35554(thiophene scaffold, 21)copy SMILEScopy InChI
Affinity DataIC50: 16nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169932(2-(4-Chloro-phenyl)-3-cyclohexyl-1-[(dimethylcarba...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162095(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-p-tolyl-1...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169929(2-Cyclohex-1-enyl-3-cyclohexyl-1-[2-(4-dimethylami...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169916(3-Cyclohexyl-1-{[methyl-(1-methyl-piperidin-3-ylme...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162097(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-(4-methox...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169921(3-Cyclohexyl-2-[3-(3,3-difluoro-piperidin-1-ylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162096(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-(3-fluoro...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169910(3-Cyclohexyl-1-[2-(4-methanesulfonyl-piperazin-1-y...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35563(1H-benzo[de]isoquinoline-1,3(2H)-dione, 12)copy SMILEScopy InChI
Affinity DataIC50: 19nM EC50:  3.80E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetGenome polyprotein [2420-2989,P2914A,R2963Q](Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35553(1H-benzo[de]isoquinoline-1,3(2H)-dione, 1)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35553(1H-benzo[de]isoquinoline-1,3(2H)-dione, 1)copy SMILEScopy InChI
Affinity DataIC50: 20nM EC50:  7.10E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35560(1H-benzo[de]isoquinoline-1,3(2H)-dione, 9)copy SMILEScopy InChI
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162108(3-CYCLOHEXYL-1-(2-MORPHOLIN-4-YL-2-OXOETHYL)-2-PHE...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162092(3-Cyclohexyl-1-methyl-2-phenyl-1H-indole-6-carboxy...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35558(1H-benzo[de]isoquinoline-1,3(2H)-dione, 7)copy SMILEScopy InChI
Affinity DataIC50: 29nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35569(1H-benzo[de]isoquinoline-1,3(2H)-dione, 18)copy SMILEScopy InChI
Affinity DataIC50: 30nM EC50:  1.90E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169927(3-Cyclohexyl-1-dimethylcarbamoylmethyl-2-furan-3-y...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162101(1-Benzyl-3-cyclohexyl-2-phenyl-1H-indole-6-carboxy...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169933(3-Cyclohexyl-1-[2-(4-methyl-piperazin-1-yl)-2-oxo-...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein [2420-2989,P2914A,R2963Q](Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35554(thiophene scaffold, 21)copy SMILEScopy InChI
Affinity DataIC50: 40nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162093(2-(3-Chloro-phenyl)-3-cyclohexyl-1-dimethylcarbamo...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169898(3-Cyclohexyl-1-[2-(4-dimethylamino-piperidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
IRBM-MRL Rome

LigandPNGBDBM35571(1H-benzo[de]isoquinoline-1,3(2H)-dione, 20 | cis-i...)copy SMILEScopy InChI
Affinity DataIC50: 42nM EC50:  3.80E+3nMpH: 7.5 T: 2°CAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169907(3-Cyclohexyl-1-[2-(1,1-dioxo-1lambda*6*-thiomorpho...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 2b (isolate HC-J8) (HCV...)
IRBM-MRL Rome

LigandPNGBDBM35570(1H-benzo[de]isoquinoline-1,3(2H)-dione, 19)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Primer-dependent assays were performed using the homopolymeric template/primer. Compounds, polymerase and template RNA were incubated at RT for 25 mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2X928P4PubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162103(3-Cyclohexyl-1-(2-methanesulfonylamino-2-oxo-ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50169938(3-Cyclohexyl-1-[2-(4-dimethylamino-piperidin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibitory activity against by hepatitis C virus NS5B polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q24B30VNPubMed
TargetRNA-directed RNA polymerase(Hepatitis C virus)
IRBM (Merck Research Laboratories Rome)

Curated by ChEMBL
LigandPNGBDBM50162094(3-Cyclohexyl-2-phenyl-1H-indole-6-carboxylic acid ...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibitory activity against RNA dependent RNA polymerase nonstructural protein 5B in hepatitis C virus; n=1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24VXPPubMed
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