Compile Data Set for Download or QSAR
Found 562 with Last Name = 'locke' and Initial = 'ga'
LigandPNGBDBM50552696(CHEMBL4778959)copy SMILES
Affinity DataIC50: 0.220nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552697(CHEMBL4780798)copy SMILES
Affinity DataIC50: 0.280nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552697(CHEMBL4780798)copy SMILES
Affinity DataIC50: 0.460nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetHepatic triacylglycerol lipase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50525871(CHEMBL4460999)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of hepatic lipase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48G0PubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50554035(CHEMBL4790231)copy SMILES
Affinity DataIC50: 1nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50525871(CHEMBL4460999)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of endothelial lipase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48G0PubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50554034(CHEMBL4747269)copy SMILES
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50552695(CHEMBL4789200)copy SMILES
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552691(CHEMBL4750822)copy SMILES
Affinity DataIC50: 1.30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50554035(CHEMBL4790231)copy SMILES
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50552692(CHEMBL4759406)copy SMILES
Affinity DataIC50: 1.40nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552690(CHEMBL4758114)copy SMILES
Affinity DataIC50: 1.5nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552696(CHEMBL4778959)copy SMILES
Affinity DataIC50: 1.5nMAssay Description:Inhibition of GLK (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50554052(CHEMBL4763667)copy SMILES
Affinity DataIC50: 2nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50552698(CHEMBL4779496)copy SMILES
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552702(CHEMBL4748154)copy SMILES
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
LigandPNGBDBM50552693(CHEMBL4784181)copy SMILES
Affinity DataIC50: 2.60nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50509050(CHEMBL4438309)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Displacement of fluorescein-labelled probe from wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1VZMPubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50554050(CHEMBL4752248)copy SMILES
Affinity DataIC50: 2.90nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z4829PubMed
LigandPNGBDBM50509050(CHEMBL4438309)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Displacement of fluorescein-labelled probe from human cytoplasmic domain of STING G230A/R293Q double mutant (155 to 341 residues) by time-resolved FR...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1VZMPubMed
LigandPNGBDBM50552689(CHEMBL4790192)copy SMILES
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50552699(CHEMBL4784784)copy SMILES
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50507392(CHEMBL4548537 | US10981879, Example 11)copy SMILEScopy InChI
Affinity DataIC50: 4.60nMAssay Description:Inhibition of human PMN leukocytes MPO peroxidation activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W0997ZPubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50554057(CHEMBL4740830)copy SMILES
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z4829PubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM434866(7-[(3R,4S,6S,10R)-4-Benzyl-2-oxa-7,13,14-triazatet...)copy SMILES
Affinity DataIC50: 5nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
LigandPNGBDBM50552681(CHEMBL4761884)copy SMILES
Affinity DataIC50: 5.10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50525879(CHEMBL4541404)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of endothelial lipase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48G0PubMed
TargetHepatic triacylglycerol lipase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50525869(CHEMBL4587475)copy SMILEScopy InChI
Affinity DataIC50: 5.40nMAssay Description:Inhibition of hepatic lipase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48G0PubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50554056(CHEMBL4782307)copy SMILES
Affinity DataIC50: 6nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z4829PubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50507396(CHEMBL4453728)copy SMILEScopy InChI
Affinity DataIC50: 6.70nMAssay Description:Inhibition of human PMN leukocytes MPO peroxidation activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W0997ZPubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50507390(CHEMBL4482878 | US10981879, Example 3)copy SMILEScopy InChI
Affinity DataIC50: 6.80nMAssay Description:Inhibition of human PMN leukocytes MPO chlorination activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W0997ZPubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM434867(7-[(17S)-18-Phenyl-16-oxa-2,8,9-triazapentacyclo[1...)copy SMILES
Affinity DataIC50: 7nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5DKZPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM50567715(CHEMBL4855931)copy SMILES
Affinity DataIC50: 7.10nMAssay Description:Time dependent inhibition of CYP3A4 (unknown origin) measured at 30 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5DKZPubMed
LigandPNGBDBM50509050(CHEMBL4438309)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMAssay Description:Displacement of fluorescein-labelled probe from wild type human His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1VZMPubMed
LigandPNGBDBM50558665(CHEMBL4776666)copy SMILES
Affinity DataIC50: 7.20nMAssay Description:Displacement of fluorescein-labelled probe from human cytoplasmic domain of STING G230A/R293Q double mutant (155 to 341 residues) by time-resolved FR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1VZMPubMed
LigandPNGBDBM50552688(CHEMBL4748045)copy SMILES
Affinity DataIC50: 7.30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
LigandPNGBDBM50558665(CHEMBL4776666)copy SMILES
Affinity DataIC50: 7.70nMAssay Description:Displacement of fluorescein-labelled probe from wild type mouse His-tagged STING cytoplasmic domain (155 to 341 residues) by time-resolved FRET-based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1VZMPubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM434851(7-{17-Oxa-3,4,10-triazatetracyclo[17.3.1.13,6.112,...)copy SMILES
Affinity DataIC50: 8nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5DKZPubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50507391(CHEMBL4594116 | US10981879, Example 153)copy SMILEScopy InChI
Affinity DataIC50: 8.5nMAssay Description:Inhibition of human PMN leukocytes MPO peroxidation activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W0997ZPubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50507390(CHEMBL4482878 | US10981879, Example 3)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMAssay Description:Inhibition of human PMN leukocytes MPO peroxidation activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W0997ZPubMed
LigandPNGBDBM50552684(CHEMBL4749598)copy SMILES
Affinity DataIC50: 9.30nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50554054(CHEMBL4751166)copy SMILES
Affinity DataIC50: 9.30nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z4829PubMed
LigandPNGBDBM50552700(CHEMBL4741772)copy SMILES
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))TBA
LigandPNGBDBM50567722(CHEMBL4862053)copy SMILES
Affinity DataIC50: 11nMAssay Description:Time dependent inhibition of CYP3A4 (unknown origin) measured at 30 minsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5DKZPubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50507394(CHEMBL4531688)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human PMN leukocytes MPO peroxidation activity using H2O2 as substrate preincubated for 10 mins followed by H2O2 addition and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2W0997ZPubMed
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50525869(CHEMBL4587475)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of endothelial lipase (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48G0PubMed
LigandPNGBDBM50552682(CHEMBL4745378)copy SMILES
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM434846(7-{18-oxa-3,4,10-triazatetracyclo[17.3.1.13,6.113,...)copy SMILES
Affinity DataIC50: 14nMAssay Description:Inhibition of MPO (unknown origin) chlorination activity incubated for 10 mins followed by NaCl addition by aminophenyl fluorescein assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PZ5DKZPubMed
TargetMyeloperoxidase(Homo sapiens (Human))TBA
LigandPNGBDBM50554051(CHEMBL4795827)copy SMILES
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human MPO incubated for 10 mins in presence of 120 mM NaCl by aminophenyl fluorescein based assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21Z4829PubMed
LigandPNGBDBM50552686(CHEMBL4776227)copy SMILES
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged HPK1 (1 to 346 residues) expressed in baculovirus infected Sf9 cells using NH2-fluorescein-RFAR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DN48N7PubMed
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