Compile Data Set for Download or QSAR
Found 57 with Last Name = 'wohlhieter' and Initial = 'ge'
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312750((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312744((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 6.10nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312755((S)-3-(4-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)copy SMILEScopy InChI
Affinity DataIC50: 8.90nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312757((S)-3-(3,4-difluorophenyl)-N1-(5-(3-methyl-1H-inda...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312765((S)-3-(3-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312756((S)-3-(2,4-dichlorophenyl)-N1-(5-(3-methyl-1H-inda...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312765((S)-3-(3-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312757((S)-3-(3,4-difluorophenyl)-N1-(5-(3-methyl-1H-inda...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312749((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312750((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312747((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312744((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312764((S)-3-(3-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-...)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312751((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312749((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312762((S)-3-(2-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312762((S)-3-(2-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312756((S)-3-(2,4-dichlorophenyl)-N1-(5-(3-methyl-1H-inda...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312759((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312755((S)-3-(4-chlorophenyl)-N1-(5-(3-methyl-1H-indazol-...)copy SMILEScopy InChI
Affinity DataIC50: 72nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312748((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312759((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 76nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312746((S)-N1-(5-(3-phenyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312761((S)-3-(2-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-...)copy SMILEScopy InChI
Affinity DataIC50: 104nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312745((S)-N1-(5-(3-cyclopropyl-1H-indazol-5-yl)-1,3,4-th...)copy SMILEScopy InChI
Affinity DataIC50: 135nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312750((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 154nMAssay Description:Inhibition of human AKT1 in human MDA-MB-468 cells assessed as phosphorylation-mediated nuclear translocation of GFP-tagged FKHRL1 by fluorescence mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312745((S)-N1-(5-(3-cyclopropyl-1H-indazol-5-yl)-1,3,4-th...)copy SMILEScopy InChI
Affinity DataIC50: 181nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312763((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 198nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312761((S)-3-(2-fluorophenyl)-N1-(5-(3-methyl-1H-indazol-...)copy SMILEScopy InChI
Affinity DataIC50: 198nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 247nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312753((S)-N1-(5-(3-methylisoquinolin-6-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312751((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 323nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 333nMAssay Description:Inhibition of human AKT1 in human MDA-MB-468 cells assessed as phosphorylation-mediated nuclear translocation of GFP-tagged FKHRL1 by fluorescence mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312754((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 357nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312748((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 368nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312758((S)-N1-(5-(3-ethyl-1H-indazol-5-yl)-1,3,4-thiadiaz...)copy SMILEScopy InChI
Affinity DataIC50: 370nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312746((S)-N1-(5-(3-phenyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 413nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312750((S)-N1-(5-(1H-indazol-5-yl)-1,3,4-thiadiazol-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 444nMAssay Description:Inhibition of human AKT1 in human U87MG cells assessed as PRAS40 phosphorylation after 1 hr by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312763((S)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 491nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312753((S)-N1-(5-(3-methylisoquinolin-6-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 607nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 695nMAssay Description:Inhibition of human AKT1 in human MDA-MB-468 cells assessed as phosphorylation-mediated nuclear translocation of GFP-tagged FKHRL1 by fluorescence mi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50025671(CHEMBL583413)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Induction of p53-Ser15 phosphorylation in human HCT116 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GRQPubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Induction of p53 in human HCT116 cells coexpressing pp53TA-luc assessed as inhibition of cell proliferation after 8 hrs by firefly/renilla luciferase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GRQPubMed
TargetCellular tumor antigen p53(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50229787((4S,5R)-Nutlin-3 | (rac)-(4,5-bis(4-chlorophenyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Induction of p53-Ser15 phosphorylation in human HCT116 cells after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZK5GRQPubMed
TargetSerine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312752((S)-N1-(5-(isoquinolin-6-yl)-1,3,4-thiadiazol-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of SGK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Amgen Inc.

Curated by ChEMBL
LigandPNGBDBM50312760((R)-N1-(5-(3-methyl-1H-indazol-5-yl)-1,3,4-thiadia...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of AKT1 after 10 mins by [gamma33]ATP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21836MCPubMed
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