Compile Data Set for Download or QSAR
Found 122 with Last Name = 'orr' and Initial = 'gf'
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1803(2-Amino-6-arylthiobenzonitrile deriv. 3w | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1804(2-Amino-6-arylthiobenzonitrile deriv. 3x | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1802(2-Amino-6-arylthiobenzonitrile deriv. 3v, 739W94 |...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1805(2-Amino-6-arylthiobenzonitrile deriv. 3y | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030972(5-(3-sec-Butoxy-benzyl)-1-(2-hydroxy-ethoxymethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1778(2-Amino-6-arylthiobenzonitrile deriv. 3ff | 2-amin...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1801(2-Amino-6-arylthiobenzonitrile deriv. 3u | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1806(2-Amino-6-arylthiobenzonitrile deriv. 3z | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50031005(1-(2-Hydroxy-ethoxymethyl)-5-(3-propoxy-benzyl)-1H...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030974(1-(2-Hydroxy-1-hydroxymethyl-ethoxymethyl)-5-(3-pr...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50031009(1-(2-Hydroxy-ethoxymethyl)-5-(3-isobutoxy-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030990(5-[3-(3-Fluoro-propoxy)-benzyl]-1-(2-hydroxy-ethox...)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030980(1-((2-HYDROXYETHOXY)METHYL)-5-(3-(BENZYLOXY)BENZYL...)copy SMILEScopy InChI
Affinity DataIC50: 84nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50031006(5-(3-Ethoxy-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030999(5-(3-Chloro-benzyl)-1-(2-hydroxy-1-hydroxymethyl-e...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50031007(5-[3-(3-Fluoro-propoxy)-benzyl]-1-(2-hydroxy-1-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1751(2-Amino-6-arylthiobenzonitrile deriv. 1u | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 120nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030983(5-(3-Allyloxy-benzyl)-1-(2-hydroxy-ethoxymethyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1753(2-Amino-6-arylthiobenzonitrile deriv. 1w | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 140nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50031004(1-(2-Hydroxy-ethoxymethyl)-5-(3-isopropoxy-benzyl)...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030995(5-(3-Butoxy-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 160nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1786(2-Amino-6-arylthiobenzonitrile deriv. 3f | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetAmine oxidase [flavin-containing] B(Homo sapiens (Human))
GlaxoSmithKline Research and Development

Curated by ChEMBL
LigandPNGBDBM50122955(2-(4,6-Difluoro-indan-1-ylidene)-acetamide | CHEMB...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration of the compound against Monoamine oxidase B (MAO-B)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5N7FPubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1792(2-Amino-6-arylthiobenzonitrile deriv. 3l | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030984(5-(3-Chloro-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1800(2-Amino-6-arylthiobenzonitrile deriv. 3t | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030981(5-(3,5-Difluoro-benzyl)-1-(2-hydroxy-ethoxymethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1789(2-Amino-6-arylthiobenzonitrile deriv. 3i | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1776(2-Amino-6-arylthiobenzonitrile deriv. 3dd | 2-amin...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50026387(1-((2-HYDROXYETHOXY)METHYL)-5-BENZYLPYRIMIDINE-2,4...)copy SMILEScopy InChI
Affinity DataIC50: 460nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1769(2-Amino-6-arylthiobenzonitrile deriv. 2n | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1771(2-Amino-6-arylthiobenzonitrile deriv. 2p | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 520nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030976(5-(3-Fluoro-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 550nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1783(2-Amino-6-arylthiobenzonitrile deriv. 3c | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50031001(5-(3-Propoxy-benzyl)-1H-pyrimidine-2,4-dione | CHE...)copy SMILEScopy InChI
Affinity DataIC50: 840nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030975(5-(2-Fluoro-benzyl)-1-(2-hydroxy-ethoxymethyl)-1H-...)copy SMILEScopy InChI
Affinity DataIC50: 870nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1772(2-Amino-6-arylthiobenzonitrile deriv. 2q | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 900nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1736(2-Amino-6-arylthiobenzonitrile deriv. 1f | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 960nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1777(2-(4a,8a-dihydronaphthalene-1-sulfonyl)-6-aminoben...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1745(2-Amino-6-arylthiobenzonitrile deriv. 1o | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50031000(5-(3-sec-Butoxy-benzyl)-1H-pyrimidine-2,4-dione | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1750(2-Amino-6-arylthiobenzonitrile deriv. 1t | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50031002(5-(3-Isobutoxy-benzyl)-1H-pyrimidine-2,4-dione | C...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1782(2-Amino-6-arylthiobenzonitrile deriv. 3b | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50031012(5-[3-(3-Fluoro-propoxy)-benzyl]-1H-pyrimidine-2,4-...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1733(2-Amino-6-arylthiobenzonitrile deriv. 1c | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1752(2-Amino-6-arylthiobenzonitrile deriv. 1v | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMpH: 8.0Assay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetGag-Pol polyprotein [588-1027]/[588-1147](Human immunodeficiency virus type 1)
GlaxoSmithKline

LigandPNGBDBM1797(2-Amino-6-arylthiobenzonitrile deriv. 3q | 2-amino...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FJ2F09PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50031010(1-(2-Hydroxy-ethoxymethyl)-5-(3-methoxy-benzyl)-1H...)copy SMILEScopy InChI
Affinity DataIC50: 1.86E+3nMAssay Description:The compound was tested for inhibition of uridine phosphorylase (UrdPase) from murine liver Value refers to activity for apparent Ki valueMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
TargetUridine phosphorylase 1(Mus musculus)
Burroughs Wellcome Co.

Curated by ChEMBL
LigandPNGBDBM50030992(5-(3-Isopropoxy-benzyl)-1H-pyrimidine-2,4-dione | ...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of uridine phosphorylase (UrdPase) from murine liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2B27T91PubMed
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