Compile Data Set for Download or QSAR
Found 276 with Last Name = 'cutler' and Initial = 'gj'
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50418169(CHEMBL1761516)copy SMILEScopy InChI
Affinity DataIC50: 7.94nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VS3PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50418165(CHEMBL1761512)copy SMILEScopy InChI
Affinity DataIC50: 12.6nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VS3PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50395539(CHEMBL483165)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413883(CHEMBL520473)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50230828(5-(4-fluorophenyl)-2-ureidothiophene-3-carboxamide...)copy SMILEScopy InChI
Affinity DataIC50: 19.9nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VS3PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50418166(CHEMBL1761513)copy SMILEScopy InChI
Affinity DataIC50: 19.9nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VS3PubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413871(CHEMBL473080 | D3RKN_32)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant ROCK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413882(CHEMBL482747)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413881(CHEMBL519965)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50395539(CHEMBL483165)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50395528(CHEMBL483557)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
LigandPNGBDBM27450(5-[5-(3-hydroxypropoxy)-6-methoxy-1H-1,3-benzodiaz...)copy SMILEScopy InChI
Affinity DataIC50: 25nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ311MPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50418167(CHEMBL1761514)copy SMILEScopy InChI
Affinity DataIC50: 25.1nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VS3PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413875(CHEMBL482539)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50169697(CHEMBL182254 | [3-Chloro-4-(3-fluoro-benzyloxy)-ph...)copy SMILEScopy InChI
Affinity DataIC50: 32nMpH: 7.5Assay Description:Inhibitory concentration against EGFR by using [gamma-33P]-ATP as radioligand in pH 7.5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84BDMPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413877(CHEMBL482540)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
LigandPNGBDBM27452(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-me...)copy SMILEScopy InChI
Affinity DataIC50: 40nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ311MPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413871(CHEMBL473080 | D3RKN_32)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413877(CHEMBL482540)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413884(CHEMBL483166)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50350908(CHEMBL520308)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50169696((4-Benzyloxy-3-chloro-phenyl)-(1,3,8a,9-tetraaza-f...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 7.5Assay Description:Inhibitory concentration against EGFR by using [gamma-33P]-ATP as radioligand in pH 7.5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84BDMPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413880(CHEMBL482746)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
LigandPNGBDBM27449(5-{6-methoxy-5-[2-(morpholin-4-yl)ethoxy]-1H-1,3-b...)copy SMILEScopy InChI
Affinity DataIC50: 50nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ311MPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413885(CHEMBL485145)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50169697(CHEMBL182254 | [3-Chloro-4-(3-fluoro-benzyloxy)-ph...)copy SMILEScopy InChI
Affinity DataIC50: 63nMpH: 7.5Assay Description:Inhibitory concentration against ErbB-2 protein tyrosine kinase by using [gamma-33P]-ATP as radioligand in pH 7.5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84BDMPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413880(CHEMBL482746)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM27476(2-amino-5-(pyridin-4-yl)-3-(4-sulfamoylphenyl)benz...)copy SMILEScopy InChI
Affinity DataIC50: 79nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ289WPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM29411(7-alkoxyisoquinoline, 21)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1GX7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM27467(2-amino-5-(4-chlorophenyl)-3-(4-sulfamoylphenyl)be...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ289WPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM29407(7-alkoxyisoquinoline, 17)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1GX7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM29410(7-alkoxyisoquinoline, 20)copy SMILEScopy InChI
Affinity DataIC50: 126nMAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1GX7PubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
GSK

LigandPNGBDBM27444(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-me...)copy SMILEScopy InChI
Affinity DataIC50: 126nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ311MPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413883(CHEMBL520473)copy SMILEScopy InChI
Affinity DataIC50: 126nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413882(CHEMBL482747)copy SMILEScopy InChI
Affinity DataIC50: 126nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
GSK

LigandPNGBDBM27443(5-(1H-1,3-benzodiazol-1-yl)-3-[(4-methylphenyl)met...)copy SMILEScopy InChI
Affinity DataIC50: 126nMpH: 7.2 T: 2°CAssay Description:The compound inhibitory activity was determined by incubation with purified PLK1 and biotinylated peptide substrate in the presence ATP/[gamma-33P]AT...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ311MPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413881(CHEMBL519965)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM29423(7-alkoxyisoquinoline, 33)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1GX7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit alpha(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413872(CHEMBL519028)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Inhibition of human recombinant IKK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413878(CHEMBL453707)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM27489(2-amino-3-{4-[(2-aminoethyl)sulfamoyl]phenyl}-5-ph...)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ289WPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM27477(2-amino-5-(4-methanesulfonylphenyl)-3-(4-sulfamoyl...)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ289WPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM29421(7-alkoxyisoquinoline, 31)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1GX7PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50418163(CHEMBL1761510)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Inhibition of IKK-betaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VS3PubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50418165(CHEMBL1761512)copy SMILEScopy InChI
Affinity DataIC50: 158nMAssay Description:Inhibition of IKK-beta in human PBMC assessed as TNF-alpha-induced Nuclear factor-kappa-B nuclear translocationMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VS3PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50169701((3-Chloro-4-fluoro-phenyl)-(1,3,8a,9-tetraaza-fluo...)copy SMILEScopy InChI
Affinity DataIC50: 200nMpH: 7.5Assay Description:Inhibitory concentration against EGFR by using [gamma-33P]-ATP as radioligand in pH 7.5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84BDMPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM27466(2-amino-5-(4-fluorophenyl)-3-(4-sulfamoylphenyl)be...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ289WPubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL
LigandPNGBDBM50169696((4-Benzyloxy-3-chloro-phenyl)-(1,3,8a,9-tetraaza-f...)copy SMILEScopy InChI
Affinity DataIC50: 200nMpH: 7.5Assay Description:Inhibitory concentration against ErbB-2 protein tyrosine kinase by using [gamma-33P]-ATP as radioligand in pH 7.5More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84BDMPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50413876(CHEMBL520954)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant IKK2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GF0VRNPubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM27492(2-amino-5-phenyl-3-(4-{[2-(pyrrolidin-1-yl)ethyl]s...)copy SMILEScopy InChI
Affinity DataIC50: 251nMAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QZ289WPubMed
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