Affinity DataKi: 310nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataKi: 2.20E+4nMAssay Description:Inhibition of HCV NS5B polymerase S282T mutant assessed as incorporation of [alpha32P]UTP into newly synthesized RNA by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 400nMAssay Description:Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.31E+3nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
In DepthDetails
Affinity DataIC50: 6.22E+3nMAssay Description:Inhibition of TPH-1-mediated serotonin biosynthesis in rat RBL2H3 cells after 48 hrs by RP-HPLC analysisMore data for this Ligand-Target Pair
In DepthDetails
In DepthDetails
Affinity DataIC50: 1.04E+4nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
In DepthDetails
In DepthDetails
In DepthDetails
In DepthDetails
In DepthDetails
In DepthDetails
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
303A College Road East
Curated by ChEMBL
303A College Road East
Curated by ChEMBL
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
Affinity DataIC50: 4.55E+4nMAssay Description:Inhibition of TPH-2-mediated serotonin biosynthesis in rat PC12 cells after 48 hrs by RP-HPLC analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.67E+4nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Affinity DataIC50: 8.50E+4nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DNA polymerase beta assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of HCV genotype 1b recombinant NS5B RNA dependent RNA polymerase S282T mutant using IRES RNA as substrate after 30 mins by radioactive ass...More data for this Ligand-Target Pair
TargetDNA-directed RNA polymerase II subunit RPB1(Homo sapiens (Human))
303A College Road East
Curated by ChEMBL
303A College Road East
Curated by ChEMBL
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human RNA polymerase 2More data for this Ligand-Target Pair
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
303A College Road East
Curated by ChEMBL
303A College Road East
Curated by ChEMBL
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
TargetDNA-directed RNA polymerase II subunit RPB1(Homo sapiens (Human))
303A College Road East
Curated by ChEMBL
303A College Road East
Curated by ChEMBL
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibition of human RNA polymerase 2More data for this Ligand-Target Pair
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
303A College Road East
Curated by ChEMBL
303A College Road East
Curated by ChEMBL
Affinity DataIC50: 5.50E+5nMAssay Description:Inhibition of human DNA polymerase alpha assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human DNA polymerase gamma assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper bindin...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibition of human DNA polymerase beta assessed as incorporation of [alpha-32P]dCTP up to 1mM preincubated for 30 mins by whatman DE81 paper binding...More data for this Ligand-Target Pair
In DepthDetails
In DepthDetails
Affinity DataKd: 6.82E+3nMAssay Description:Binding affinity to TPH-1 (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
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