Compile Data Set for Download or QSAR
Found 127 with Last Name = 'gullberg' and Initial = 'h'
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466891(CHEMBL4281109)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466897(CHEMBL4287715)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466893(CHEMBL4291727)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466892(CHEMBL4283871)copy SMILEScopy InChI
Affinity DataKi:  1.20E+3nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466913(CHEMBL4289304)copy SMILEScopy InChI
Affinity DataKi:  1.90E+4nMAssay Description:Displacement of [3H]-25-hydroxycholesterol from human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cell...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477604((R)—N-(1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate in presence of 2 nM of DHODH by DCIP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477604((R)—N-(1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477616((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate in presence of 2 nM of DHODH by DCIP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477601(N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydro-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477601(N-[1-(2,3-dimethylphenyl)-4,5,6,7-tetrahydro-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate in presence of 2 nM of DHODH by DCIP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466890(CHEMBL4290728)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477599(N-[1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-indazo...)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate in presence of 2 nM of DHODH by DCIP assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477599(N-[1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-indazo...)copy SMILEScopy InChI
Affinity DataIC50: 3.80nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466912(CHEMBL4283051)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466897(CHEMBL4287715)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466891(CHEMBL4281109)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477616((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466890(CHEMBL4290728)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466893(CHEMBL4291727)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477618((R)—N-(1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-in...)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477586(N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrahydro-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466914(CHEMBL4283312)copy SMILEScopy InChI
Affinity DataIC50: 7.60nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466915(CHEMBL4282848)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477583(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189877(US10227346, Example 5 | US10426135, Example 5 | US...)copy SMILEScopy InChI
Affinity DataIC50: 9.5nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189922(US10227346, Example 109 | US10426135, Example 109 ...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466908(CHEMBL4283530)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477619((R)—N-(1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrahy...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466895(CHEMBL4281170)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477584(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of recombinant human N-terminal His-tagged DHODH (31 to 395 residues) expressed in Escherichia coli expression system using dihydroorotic ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477600(N-[1-(3-methylphenyl)-4,5,6,7-tetrahydro-1H-indazo...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466908(CHEMBL4283530)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466909(CHEMBL4284588)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466911(CHEMBL4288376)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189909(US10227346, Example 33 | US10426135, Example 33 | ...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466907(CHEMBL4291498)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477609(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466910(CHEMBL4292862)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477595(4-methyl-N-[(4R)-1-(2-methylphenyl)-4,5,6,7-tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189909(US10227346, Example 33 | US10426135, Example 33 | ...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477592(N-(1-phenyl-4,5,6,7-tetrahydro-1H-indazol-4-yl)-4,...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466899(CHEMBL4295241)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189923(US10227346, Example 110 | US10426135, Example 110 ...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466904(CHEMBL4286366)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at human N-terminal 6His-tagged-RORC2 LBD (259 to 483 residues) expressed in Escherichia coli (DE3) cells assessed as inhibi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM50466911(CHEMBL4288376)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477614(N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrahydro-1H-i...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477621(N-[(4R)-1-(2-fluoro-5-methylphenyl)-4,5,6,7-tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Karo Bio AB (now Karo Pharma AB)

Curated by ChEMBL
LigandPNGBDBM189922(US10227346, Example 109 | US10426135, Example 109 ...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inverse agonist activity at RORC2 in human Th17 cells assessed as inhibition of IL17A production after 6 days by sandwich ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27P922TPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Karolinska Institutet

Curated by ChEMBL
LigandPNGBDBM477606(4-chloro-N-[(4R)-1-(2-fluorophenyl)-4,5,6,7-tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human DHODH using dihydroorotic acid as substrate measured for 68 mins by DCIP based colorimetric assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2HQ43F3PubMed
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