TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataKi: 300nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataKi: 3.80E+3nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataKi: 1.10E+5nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 0.0800nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 0.100nMAssay Description:Inhibition of wild type EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:Inhibition of wild type EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2T43T7NPubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2T43T7NPubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 0.220nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 0.400nM Kd: 11nMAssay Description:Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach.More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 0.400nM Kd: 11nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 0.430nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1210,T790M](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of wild type EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1210,T790M](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 3.60nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In DepthDetails
Article
BindingDB Entry DOI: 10.7270/Q2R20ZQ4PubMedDrugBank
MMDB
PDB
3D Structure (crystal)
BindingDB Entry DOI: 10.7270/Q2R20ZQ4PubMedDrugBank
MMDB
PDB
![3D 3D](/images/Docked_3d.png)
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 6.30nM Kd: 8nMAssay Description:Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach.More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 14nM Kd: 56nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of wild type EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of wild type EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 21nM Kd: 73nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 23nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inhibition of wild type EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 34nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 71nM Kd: 174nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 101nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 150nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 207nM Kd: 256nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 235nM Kd: 239nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,S345C](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 236nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1210,T790M](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 260nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,S345C](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 340nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1210,T790M](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 360nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 480nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 689nMAssay Description:Inhibition of human recombinant EGFR expressed in baculovirus-infected Sf9 cells by radioactive phosphotransfer assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,S345C](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 990nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M,S345C](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 2.81E+3nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of Fyn expressed in Escherichia coli C43 by radioactive phosphotransfer assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M,S345C](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 5.71E+3nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,S345C](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 6.40E+3nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 6.40E+3nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Chemical Genomics Centre of the Max Planck Society
Curated by ChEMBL
Affinity DataIC50: 1.28E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M,S345C](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society
Chemical Genomics Centre of the Max Planck Society
Affinity DataIC50: 1.50E+4nMpH: 7.5 T: 2°CAssay Description:IC50 values were determined with the Z lyte assay system (Invitrogen). The reactions were performed in 384-well small volume plates from Greiner (#7...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
University of California
Curated by ChEMBL
University of California
Curated by ChEMBL
Affinity DataIC50: 1.63E+4nMAssay Description:Inhibition of c-src in by radioactive phosphotransfer assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.63E+4nMAssay Description:Inhibition of Fyn expressed in Escherichia coli C43 by radioactive phosphotransfer assayMore data for this Ligand-Target Pair
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