Compile Data Set for Download or QSAR
Found 317 with Last Name = 'lewis' and Initial = 'hd'
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480056(CHEMBL468083)copy SMILEScopy InChI
Affinity DataIC50: 0.0300nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480058(CHEMBL495009)copy SMILEScopy InChI
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480057(CHEMBL523832)copy SMILEScopy InChI
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480052(CHEMBL467457)copy SMILEScopy InChI
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480051(CHEMBL512282)copy SMILEScopy InChI
Affinity DataIC50: 0.0600nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480062(CHEMBL511572)copy SMILEScopy InChI
Affinity DataIC50: 0.0700nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480065(CHEMBL495185)copy SMILEScopy InChI
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480059(CHEMBL523883)copy SMILEScopy InChI
Affinity DataIC50: 0.120nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480063(CHEMBL511928)copy SMILEScopy InChI
Affinity DataIC50: 0.150nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480066(CHEMBL494588)copy SMILEScopy InChI
Affinity DataIC50: 0.170nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
LigandPNGBDBM50135575((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 0.200nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480050(CHEMBL511375)copy SMILEScopy InChI
Affinity DataIC50: 0.210nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50171224(CHEMBL196215 | Cyclic sulfamide)copy SMILEScopy InChI
Affinity DataIC50: 0.240nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
LigandPNGBDBM50135589((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480054(CHEMBL506323)copy SMILEScopy InChI
Affinity DataIC50: 0.340nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480053(CHEMBL466421)copy SMILEScopy InChI
Affinity DataIC50: 0.410nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480060(CHEMBL466256)copy SMILEScopy InChI
Affinity DataIC50: 0.420nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480055(CHEMBL513674)copy SMILEScopy InChI
Affinity DataIC50: 0.420nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480061(CHEMBL512596)copy SMILEScopy InChI
Affinity DataIC50: 0.460nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
LigandPNGBDBM50135578(4-{3-[(S)-3-(3,4-Difluoro-phenyl)-2-methyl-propion...)copy SMILEScopy InChI
Affinity DataIC50: 0.490nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480064(CHEMBL494769)copy SMILEScopy InChI
Affinity DataIC50: 0.820nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
LigandPNGBDBM50135579((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-1-(2-hydroxy-et...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50135584((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
TargetPresenilin-1(Homo sapiens (Human))
Merck Sharp & Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50480067(CHEMBL492394)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of gamma secretase in human SH-SY5Y cells by HTRF assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2B85BZ2PubMed
LigandPNGBDBM50135582((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-2,3-dihyd...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50135586((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-methylcarbamo...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50135591((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50535083(CHEMBL4460676)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant SYK expressed in baculovirus using Biotin-AAAEEIYGEI as substrate after 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM8BT3PubMed
LigandPNGBDBM50186575(CHEMBL377206 | cis-methyl 4-(3-(4-chlorophenylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of gamma secretase expressed in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02DTPubMed
LigandPNGBDBM50135581((S)-3-(3,4-Difluoro-phenyl)-2-methyl-N-[(S)-1-meth...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50135590((S)-N-[(S)-5-Benzo[1,3]dioxol-5-yl-2-oxo-1-(3-oxo-...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50419265(CHEMBL1835069)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD12ZWPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50535112(CHEMBL4439328)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant SYK expressed in baculovirus using Biotin-AAAEEIYGEI as substrate after 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM8BT3PubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50535084(CHEMBL3546703)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant SYK expressed in baculovirus using Biotin-AAAEEIYGEI as substrate after 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM8BT3PubMed
LigandPNGBDBM50135588((S)-3-(3,4-Difluoro-phenyl)-N-[(S)-5-(2,3-dihydro-...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50535097(CHEMBL4561098)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant SYK expressed in baculovirus using Biotin-AAAEEIYGEI as substrate after 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM8BT3PubMed
LigandPNGBDBM50135577((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-dimethylcarba...)copy SMILEScopy InChI
Affinity DataIC50: 5.5nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50535093(CHEMBL4472827)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant SYK expressed in baculovirus using Biotin-AAAEEIYGEI as substrate after 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM8BT3PubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)copy SMILEScopy InChI
Affinity DataIC50: 6.30nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50535107(CHEMBL4468047)copy SMILEScopy InChI
Affinity DataIC50: 7.90nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant SYK expressed in baculovirus using Biotin-AAAEEIYGEI as substrate after 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GM8BT3PubMed
LigandPNGBDBM50186574(CHEMBL209695 | cis-3-(3-(4-chlorophenylsulfonyl)-3...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of gamma secretase expressed in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02DTPubMed
LigandPNGBDBM50186573(CHEMBL377398 | cis-(E)-methyl 4-(3-(4-chlorophenyl...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of gamma secretase expressed in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02DTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50419258(CHEMBL1835070)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD12ZWPubMed
LigandPNGBDBM50186581(CHEMBL377413 | cis-methyl 4-(3-(4-chlorophenylsulf...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of gamma secretase expressed in SH-SY5Y cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BP02DTPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50419256(CHEMBL1835065 | US9579320, Example 302)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human full-length recombinant 6His-SYK assessed as phosphorylation of Biotin-AAAEEIYGEI substrate after 60 mins by by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD12ZWPubMed
LigandPNGBDBM50135587(CHEMBL335994 | {(S)-5-Benzo[1,3]dioxol-5-yl-3-[(S)...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50135585((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-methyl-2-oxo-...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
LigandPNGBDBM50135583((S)-N-((S)-5-Benzo[1,3]dioxol-5-yl-1-carbamoylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:In vitro inhibition of gamma secretase.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22V2FHQPubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50535089(CHEMBL4528289)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal 6His-tagged full length human recombinant SYK expressed in baculovirus using Biotin-AAAEEIYGEI as substrate after 60 mins by...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetMitogen-activated protein kinase 1/3(Homo sapiens (Human))
GlaxoSmithKline R&D

Curated by ChEMBL
LigandPNGBDBM50396073(CHEMBL1235110)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of Erk1/2 phosphorylation expressed in ramos cells after 30 mins by MSD assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2XD12ZWPubMed
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