Affinity DataIC50: 0.200nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human ERG by fluorescently labeled tracer binding methodMore data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-evoked currents by two-electrode voltage cl...More data for this Ligand-Target Pair
Affinity DataIC50: 2.40nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
TargetNicotinic acetylcholine receptor alpha9/alpha10(RAT)
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of rat alpha9alpha10 nAChRMore data for this Ligand-Target Pair
Affinity DataIC50: 4.90nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetNicotinic acetylcholine receptor alpha9/alpha10(RAT)
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 6.90nMAssay Description:Inhibition of rat alpha9alpha10 nAChRMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2 channel assessed as inhibition of CaV2.2-mediated Ba2+ pe...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Agonist activity at human GABAB expressed in HEK293T cells co-transfected with human CaV2.2 channel assessed as inhibition of CaV2.2-mediated Ba2+ pe...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-evoked currents by two-electrode voltage cl...More data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Activation of human GABAB1/GABAB2 expressed in HEK293 cells co-transfected with rat CaV2.2 channel assessed as reduction in CaV2.2-mediated peak-curr...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 26nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetNicotinic acetylcholine receptor alpha9/alpha10(RAT)
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 28nMAssay Description:Inhibition of rat alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -80 mV holding potential ...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 34nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-evoked currents by two-electrode voltage cl...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Inhibition of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-evoked currents by two-electrode voltage clamp ass...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:Binding affinity to MDM2More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
TargetNicotinic acetylcholine receptor alpha9/alpha10(RAT)
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 109nMAssay Description:Inhibition of rat alpha9alpha10 nAChRMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 117nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes expressing alpha9:alpha10 mRNA injection ratio of 1:3 assessed as inhibit...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 126nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 148nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 155nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 181nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 201nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 219nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 231nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 249nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-evoked currents by two-electrode voltage cl...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 256nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 266nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-evoked currents by two-electrode voltage cl...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 288nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 354nMAssay Description:Inhibition of human alpha7 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of ACh-evoked currents by two-electrode voltage clamp ass...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 363nMAssay Description:Inhibition of human alpha9alpha10 nAChR expressed in Xenopus laevis oocytes assessed as inhibition of Ach-induced response at -80 mV holding potentia...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor(Homo sapiens (Human))
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Korea Advanced Institute of Science and Technology (KAIST)
Curated by ChEMBL
Affinity DataIC50: 377nMAssay Description:Inhibition of human wild type ALK using YRRAAVPPSPSLSRHSSPHQ(pS)EDEEE as substrate preincubated for 20 mins followed by [gamma-33P]-ATP addition afte...More data for this Ligand-Target Pair
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
Institute of Basic Science (IBS)
Curated by ChEMBL
Institute of Basic Science (IBS)
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrateMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1(Homo sapiens (Human))
Institute of Basic Science (IBS)
Curated by ChEMBL
Institute of Basic Science (IBS)
Curated by ChEMBL
Affinity DataIC50: 600nMAssay Description:Inhibition of His-tagged human MALT1 (catalytic domain-339-719 aa) by fluorescence based assay using 25 uM Ac-LRSR-AMC as substrateMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor; alpha9/alpha10(Homo sapiens (Human))
Ocean University of China
Curated by ChEMBL
Ocean University of China
Curated by ChEMBL
Affinity DataIC50: 750nMAssay Description:Inhibition of human alpha9/alpha10 G154N mutant nACHR (1:3) expressed in Xenopus laevis oocyte assessed as inhibition of ACh induced channel current ...More data for this Ligand-Target Pair
![](/img/powered_by_small.gif)