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Found 357 with Last Name = 'lo' and Initial = 'hy'
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM130670(US8829200, 3)copy SMILEScopy InChI
Affinity DataIC50: 0.910nMT: 2°CAssay Description:Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73CDFUS Patent
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50330100(CHEMBL1271550 | N-(4-(3-(pyridin-3-yl)-5-(trifluor...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]-cDPPO from human Ephx2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69JT7PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078118(CHEMBL3417524)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078123(CHEMBL3417526)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078080(CHEMBL3417520)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078053(CHEMBL3417414)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM130685(US8829200, 22)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMT: 2°CAssay Description:Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73CDFUS Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078078(CHEMBL3417518)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078119(CHEMBL3417525)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078035(CHEMBL3417429)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078077(CHEMBL3417517)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetCathepsin G(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50349174(CHEMBL1807526)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human cathepsin G after 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B60H0PubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078146(CHEMBL3417531)copy SMILEScopy InChI
Affinity DataIC50: 2.10nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM130700(US8829200, 20)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMT: 2°CAssay Description:Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73CDFUS Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078052(CHEMBL3417415)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078036(CHEMBL3417428)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078040(CHEMBL3417425)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078038(CHEMBL3417427)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078033(CHEMBL3417431)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078043(CHEMBL3417422)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078031(CHEMBL3417508)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078115(CHEMBL3417522)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078045(CHEMBL3417421)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078141(CHEMBL3417527)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274045(3-[2-[2-(4-Cyano-phenyl)-2-oxo-ethyl]-5-(2-cyclohe...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32VMDPubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274339(CHEMBL485607 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32VMDPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078145(CHEMBL3417530)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM125960(US8772304, 22)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMpH: 7.5Assay Description:Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22F7M4MUS Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078060(CHEMBL3417511)copy SMILEScopy InChI
Affinity DataIC50: 3.5nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078059(CHEMBL3417510)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078058(CHEMBL3417509)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274471(CHEMBL485556 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32VMDPubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274470(CHEMBL485555 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32VMDPubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274669(CHEMBL485031 | N-(1-(3-(1H-imidazol-1-yl)propyl)-5...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32VMDPubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274340(CHEMBL483403 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32VMDPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM125961(US8772304, 23)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 7.5Assay Description:Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22F7M4MUS Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM125940(US8772304, 2)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMpH: 7.5Assay Description:Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22F7M4MUS Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078042(CHEMBL3417423)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50330103(CHEMBL1271608 | N-(5-(3-(pyridin-3-yl)-5-(trifluor...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of human Ephx2 after 30 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69JT7PubMed
TargetCathepsin G(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50349176(CHEMBL1807531)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Inhibition of human cathepsin G after 1 hr by fluorometric assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B60H0PubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274671(4-cyano-N-(5-(N-methylcyclohexanecarboxamido)-1-(3...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32VMDPubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274705(4-cyano-N-(5-(N-methylcyclohexanecarboxamido)-1-(3...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32VMDPubMed
TargetBifunctional epoxide hydrolase 2(Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50330103(CHEMBL1271608 | N-(5-(3-(pyridin-3-yl)-5-(trifluor...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]-cDPPO from human Ephx2 by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V69JT7PubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM50274246(CHEMBL485232 | N-(1-(3-amino-3-oxopropyl)-5-(N-met...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of ITK by DELFIA assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M32VMDPubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM26881(2-aminobenzimidazole with trans-stilbene, 8x | 5-[...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.0 T: 2°CAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B5XFWPubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM26864(2-aminobenzimidazole with trans-stilbene, 8a | N-[...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.0 T: 2°CAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B5XFWPubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Johnson & Johnson

Curated by ChEMBL
LigandPNGBDBM26860(2-aminobenzimidazole with trans-stilbene, 8c | N-[...)copy SMILEScopy InChI
Affinity DataIC50: 5nMpH: 7.0 T: 2°CAssay Description:Kinase is purified as a GST-fusion protein. The kinase activity is measured using DELFIA which utilizes europium chelate-labeled anti-phosphotyrosine...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23B5XFWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM130672(US8829200, 6)copy SMILEScopy InChI
Affinity DataIC50: 5.07nMT: 2°CAssay Description:Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G73CDFUS Patent
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM50078050(CHEMBL3417417)copy SMILEScopy InChI
Affinity DataIC50: 5.70nMAssay Description:Displacement of [125I]-L-691831 from human FLAP expressed in insect SF9 cell membranes after 2 hrs by Topcount analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2SB47GWPubMed
TargetArachidonate 5-lipoxygenase-activating protein(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM125941(US8772304, 3)copy SMILEScopy InChI
Affinity DataIC50: 5.90nMpH: 7.5Assay Description:Compounds are assessed for the ability to bind to FLAP in a binding assay that measures compound-specific displacement of an iodinated (125I) FLAP in...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q22F7M4MUS Patent
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