Compile Data Set for Download or QSAR
Found 347 with Last Name = 'cortese' and Initial = 'j'
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM19130((2E,4E,6R)-7-[4-(dimethylamino)phenyl]-N-hydroxy-4...)copy SMILEScopy InChI
Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM25142((3S,6S,9S,15aR)-9-[(2R)-butan-2-yl]-6-[(1-methoxy-...)copy SMILEScopy InChI
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29589(Faridak | LBH-589 | LBH-589B | Panobinostat | US10...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29602(benzylidenehydrazine derivative, 19)copy SMILEScopy InChI
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29593(benzylidenehydrazine derivative, 10)copy SMILEScopy InChI
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29595(benzylidenehydrazine derivative, 12)copy SMILEScopy InChI
Affinity DataIC50: 22nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120351(US8703811, 93)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120317(US8703811, 58)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29603(benzylidenehydrazine derivative, 20)copy SMILEScopy InChI
Affinity DataIC50: 36nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29599(benzylidenehydrazine derivative, 16)copy SMILEScopy InChI
Affinity DataIC50: 37nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29596(benzylidenehydrazine derivative, 13)copy SMILEScopy InChI
Affinity DataIC50: 37nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120319(US8703811, 60)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120301(US8703811, 40 | US8703811, 41)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium vivax)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM92606(DHOD Inhibitor, 5 | US8703811, 6)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120323(US8703811, 64)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29597(benzylidenehydrazine derivative, 14)copy SMILEScopy InChI
Affinity DataIC50: 41nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM92604(DHOD Inhibitor, 3 | US8703811, 1)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120324(US8703811, 65)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29594(benzylidenehydrazine derivative, 11)copy SMILEScopy InChI
Affinity DataIC50: 43nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29607(benzylidenehydrazine derivative, 24)copy SMILEScopy InChI
Affinity DataIC50: 45nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29598(benzylidenehydrazine derivative, 15)copy SMILEScopy InChI
Affinity DataIC50: 49nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120305(US8703811, 44)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM50379142(CHEMBL2012824 | US8703811, 23)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120315(US8703811, 55)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120301(US8703811, 40 | US8703811, 41)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120328(US8703811, 70)copy SMILEScopy InChI
Affinity DataIC50: 58nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29600(benzylidenehydrazine derivative, 17)copy SMILEScopy InChI
Affinity DataIC50: 59nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM19149(CHEMBL98 | N-hydroxy-N'-phenyloctanediamide | SAHA...)copy SMILEScopy InChI
Affinity DataIC50: 59nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29591(benzylidenehydrazine derivative, 8)copy SMILEScopy InChI
Affinity DataIC50: 59nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29606(benzylidenehydrazine derivative, 23)copy SMILEScopy InChI
Affinity DataIC50: 59nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM92606(DHOD Inhibitor, 5 | US8703811, 6)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM92604(DHOD Inhibitor, 3 | US8703811, 1)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM92604(DHOD Inhibitor, 3 | US8703811, 1)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM50379157(CHEMBL1234899 | US8703811, 57)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120325(US8703811, 66)copy SMILEScopy InChI
Affinity DataIC50: 67nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM92604(DHOD Inhibitor, 3 | US8703811, 1)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM50379146(CHEMBL2012829 | US8703811, 31 | US8703811, 32)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120320(US8703811, 61)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM92606(DHOD Inhibitor, 5 | US8703811, 6)copy SMILEScopy InChI
Affinity DataIC50: 83nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120303(US8703811, 42 | US8703811, 43)copy SMILEScopy InChI
Affinity DataIC50: 88nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29605(benzylidenehydrazine derivative, 22)copy SMILEScopy InChI
Affinity DataIC50: 89nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120356(US8703811, 98)copy SMILEScopy InChI
Affinity DataIC50: 89nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetHistone deacetylase(Plasmodium falciparum (isolate 3D7))
Harvard Medical School

LigandPNGBDBM29601(benzylidenehydrazine derivative, 18)copy SMILEScopy InChI
Affinity DataIC50: 90nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q26H4FRDPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120312(US8703811, 52)copy SMILEScopy InChI
Affinity DataIC50: 94nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM50379146(CHEMBL2012829 | US8703811, 31 | US8703811, 32)copy SMILEScopy InChI
Affinity DataIC50: 99nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetCytochrome P450 2C19(Homo sapiens (Human))
Institute Infectious Diseases Initiative

Curated by ChEMBL
LigandPNGBDBM50301852(2-(3-methyl-1,2-dioxaspiro[4.5]decan-3-yl)-N-(pyri...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22R3RRXPubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50379157(CHEMBL1234899 | US8703811, 57)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP2D6 using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2C24XDSPubMed
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120303(US8703811, 42 | US8703811, 43)copy SMILEScopy InChI
Affinity DataIC50: 104nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120326(US8703811, 68)copy SMILEScopy InChI
Affinity DataIC50: 105nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College

US Patent
LigandPNGBDBM120353(US8703811, 95)copy SMILEScopy InChI
Affinity DataIC50: 105nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2WD3Z7PUS Patent
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