Affinity DataIC50: 0.600nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 1.80nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 22nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 35nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 36nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Affinity DataIC50: 36nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 37nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 38nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 40nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium vivax)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 40nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 41nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Affinity DataIC50: 41nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 42nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 42nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Affinity DataIC50: 43nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 45nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 49nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 56nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 56nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 56nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 58nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 58nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
Affinity DataIC50: 59nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 60nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial [100-517](Plasmodium berghei)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 60nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 64nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 64nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 67nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 70nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 74nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 75nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 83nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 88nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Affinity DataIC50: 89nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 89nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
Affinity DataIC50: 90nMpH: 7.5 T: 2°CAssay Description:Recombinant pfHDAC-1 was assayed with substrate in the presence of test compound. The substrate concentration was kept constant at 125 uM while the c...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 94nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 99nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetCytochrome P450 2C19(Homo sapiens (Human))
Institute Infectious Diseases Initiative
Curated by ChEMBL
Institute Infectious Diseases Initiative
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of human CYP2D6 using bufuralol as substrate after 10 mins by LC-MS/MS analysisMore data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 104nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 105nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Plasmodium falciparum)
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Genzyme Corporation; Massachusetts Institute of Technology; President and Fellows of Harvard College
US Patent
Affinity DataIC50: 105nMAssay Description:Type 2 DHODH activity was monitored with either the direct assay measuring the formation of orotate or via a chromogen reduction assay using DCIP. Al...More data for this Ligand-Target Pair