Compile Data Set for Download or QSAR
Found 83 with Last Name = 'ergüden' and Initial = 'j'
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171626(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derivedMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118338(US8653111, 62)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171614(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derivedMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171633(1-(2-Fluoro-benzyl)-5-[2-(1-methyl-cyclopentyl)-ac...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171611(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derivedMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171630(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171629(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derivedMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171615(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171613(5-(3,3-Dimethyl-butyrylamino)-1-(2-trifluoromethyl...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM3527(US8524699, 18)copy SMILEScopy InChI
Affinity DataIC50: 180nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TB15J4US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM171824(US9085572, 34)copy SMILEScopy InChI
Affinity DataIC50: 180nMpH: 7.5Assay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70DMQUS Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118341(US8653111, 85)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171643(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171628(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 210nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171637(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171624(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 220nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109268(US8609698, 10)copy SMILEScopy InChI
Affinity DataIC50: 260nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G44NZ8US Patent
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171612(5-(2-Bicyclo[2.2.1]hept-2-yl-acetylamino)-1-(2-flu...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118328(US8653111, 7)copy SMILEScopy InChI
Affinity DataIC50: 340nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118344(US8653111, 103)copy SMILEScopy InChI
Affinity DataIC50: 350nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118346(US8653111, 129)copy SMILEScopy InChI
Affinity DataIC50: 360nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171631(4-{[5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benz...)copy SMILEScopy InChI
Affinity DataIC50: 390nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM171821(US9085572, 6)copy SMILEScopy InChI
Affinity DataIC50: 430nMpH: 7.5Assay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70DMQUS Patent
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171642(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 440nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM3543(US8524699, 16)copy SMILEScopy InChI
Affinity DataIC50: 480nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TB15J4US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118339(US8653111, 72)copy SMILEScopy InChI
Affinity DataIC50: 490nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118329(US8653111, 10)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118331(US8653111, 17)copy SMILEScopy InChI
Affinity DataIC50: 560nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171632(1-(2,6-Difluoro-benzyl)-5-(3,3-dimethyl-butyrylami...)copy SMILEScopy InChI
Affinity DataIC50: 650nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171616(5-(3,3-Dimethyl-thiobutyrylamino)-1-(2-fluoro-benz...)copy SMILEScopy InChI
Affinity DataIC50: 660nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118347(US8653111, 166)copy SMILEScopy InChI
Affinity DataIC50: 690nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM3555(US8524699, 3)copy SMILEScopy InChI
Affinity DataIC50: 700nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TB15J4US Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM171827(US9085572, 46)copy SMILEScopy InChI
Affinity DataIC50: 700nMpH: 7.5Assay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70DMQUS Patent
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171640(5-(4,4-Dimethyl-pentanoylamino)-1-(2-fluoro-benzyl...)copy SMILEScopy InChI
Affinity DataIC50: 740nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118345(US8653111, 113)copy SMILEScopy InChI
Affinity DataIC50: 740nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118330(US8653111, 12)copy SMILEScopy InChI
Affinity DataIC50: 750nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM171823(US9085572, 26)copy SMILEScopy InChI
Affinity DataIC50: 760nMpH: 7.5Assay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70DMQUS Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118333(US8653111, 45)copy SMILEScopy InChI
Affinity DataIC50: 780nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171638(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 850nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171621(1-Cyclohexylmethyl-5-(3,3-dimethyl-butyrylamino)-1...)copy SMILEScopy InChI
Affinity DataIC50: 860nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
Targetvon Hippel-Lindau disease tumor suppressor(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM171822(US9085572, 23)copy SMILEScopy InChI
Affinity DataIC50: 860nMpH: 7.5Assay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2H70DMQUS Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM3591(US8524699, 7)copy SMILEScopy InChI
Affinity DataIC50: 880nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TB15J4US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM3623(US8524699, 28)copy SMILEScopy InChI
Affinity DataIC50: 890nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TB15J4US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109271(US8609698, 65)copy SMILEScopy InChI
Affinity DataIC50: 900nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G44NZ8US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109269(US8609698, 18)copy SMILEScopy InChI
Affinity DataIC50: 910nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2G44NZ8US Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM3629(US8524699, 46)copy SMILEScopy InChI
Affinity DataIC50: 930nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TB15J4US Patent
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118337(US8653111, 61)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM3643(US8524699, 44)copy SMILEScopy InChI
Affinity DataIC50: 1.12E+3nMpH: 7.5 T: 2°CAssay Description:In Vitro assay determination of the activity and selectivity of HIF Prolyl 4-hydroxylase inhibitors.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2TB15J4US Patent
TargetEndothelin-converting enzyme 1(Homo sapiens (Human))
BAYER HealthCare AG

Curated by ChEMBL
LigandPNGBDBM50171641(5-(3,3-Dimethyl-butyrylamino)-1-(2-fluoro-benzyl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibitory concentration against endothelin converting enzyme 1 using bradykinin-derived substrateMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H994R9PubMed
TargetProlyl hydroxylase EGLN2(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM118336(US8653111, 60)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Hydroxylated HIF bonds specifically to the von Hippel-Lindau protein-elongin B-elongin C complex (VBC complex). This interaction occurs only if HIF i...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2GH9GMDUS Patent
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