TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human integrin alpha-4-beta-1-mediated Ramos cell adhesion to immobilized VCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 22nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 29nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 31nMAssay Description:Inhibition of human integrin alpha-4-beta-1-mediated Ramos cell adhesion to immobilized VCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 33nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 35nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 36nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 39nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 41nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 45nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 50nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 61nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 69nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 78nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 89nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research& Development
Curated by ChEMBL
Affinity DataIC50: 94nMAssay Description:Inhibition of human integrin alpha-4-beta-1-mediated Ramos cell adhesion to immobilized VCAM1More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair