Compile Data Set for Download or QSAR
Found 129 with Last Name = 'kent barbay' and Initial = 'j'
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50372987(CHEMBL258255)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373006(CHEMBL273183)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM16802((2S)-2-[(2,6-dichlorophenyl)formamido]-3-[4-(5-met...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM220233(US9290476, 77A | US9290476, 77B | US9290476, 77C)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM220233(US9290476, 77A | US9290476, 77B | US9290476, 77C)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373012(CHEMBL409728)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50372991(CHEMBL256664)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human integrin alpha-4-beta-1-mediated Ramos cell adhesion to immobilized VCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373002(CHEMBL272966)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510354(CHEMBL4441287)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373000(CHEMBL266525)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510357(CHEMBL4543938)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510349(CHEMBL4434891)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510357(CHEMBL4543938)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510355(CHEMBL4552142)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510352(CHEMBL4468588)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50372986(CHEMBL256237)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339252(US10201546, Example 126b)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339276(US10201546, Example 136a)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339227(US10201546, Example 112c | US10201546, Example 191...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50372991(CHEMBL256664)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510352(CHEMBL4468588)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373004(CHEMBL258134)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373011(CHEMBL404430)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339216((4-Chloro-3-((4,4-difluoropiperidin-1-yl)methyl)-2...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339134(US10201546, Example 68a)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373007(CHEMBL256239)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373001(CHEMBL404318)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339207(US10201546, Example 103a)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373005(CHEMBL402278)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50372999(CHEMBL256224)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373003(CHEMBL257002)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510356(CHEMBL4584135)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510349(CHEMBL4434891)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339054(US10201546, Example 14a)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM16802((2S)-2-[(2,6-dichlorophenyl)formamido]-3-[4-(5-met...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of human integrin alpha-4-beta-1-mediated Ramos cell adhesion to immobilized VCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339144(US10201546, Example 72a)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50372997(CHEMBL256493)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50372998(CHEMBL403463)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50372984(CHEMBL272513)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510350(CHEMBL4438967)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510347(CHEMBL4475244)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510343(CHEMBL4532727)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373008(CHEMBL402318)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339227(US10201546, Example 112c | US10201546, Example 191...)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50372985(CHEMBL272965)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50372988(CHEMBL403587)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50372990(CHEMBL401672)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-7(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373010(CHEMBL272548)copy SMILEScopy InChI
Affinity DataIC50: 89nMAssay Description:Inhibition of human integrin alpha-4-beta-7-mediated K562 cell adhesion to immobilized MAdCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetIntegrin alpha-4/beta-1(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research& Development

Curated by ChEMBL
LigandPNGBDBM50373006(CHEMBL273183)copy SMILEScopy InChI
Affinity DataIC50: 94nMAssay Description:Inhibition of human integrin alpha-4-beta-1-mediated Ramos cell adhesion to immobilized VCAM1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9Z6WPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM220190(US9290476, 33A | US9290476, 33B | US9290476, 33C)copy SMILEScopy InChI
Affinity DataIC50: 95nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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