Compile Data Set for Download or QSAR
Found 159 with Last Name = 'otten' and Initial = 'j'
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)copy SMILEScopy InChI
Affinity DataKi:  3.70E+3nMAssay Description:Inhibition of recombinant KRAS G12C mutant (unknown origin) assessed as rate of inactivation by LC-MS analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539762(CHEMBL4632935)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539761(CHEMBL4648852)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539765(CHEMBL4640636)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539760(CHEMBL4636611)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of KRAS G12C mutant in human MIAPaCa2 cells assessed as reduction in ERK phosphorylation incubated for 24 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033406(CHEMBL3357658)copy SMILEScopy InChI
Affinity DataIC50: 5.70nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539759(CHEMBL4646899)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180564(4-(4-bromo-2-fluorophenylamino)-N-(cyclopropylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 6.80nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539766(CHEMBL4645376)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180558(4-(4-bromo-2-fluorophenylamino)-5-fluoro-N-(2-hydr...)copy SMILEScopy InChI
Affinity DataIC50: 9.30nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50448549(CHEMBL3127106)copy SMILEScopy InChI
Affinity DataIC50: 9.90nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539754(CHEMBL4648671)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033408(CHEMBL3357656)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033406(CHEMBL3357658)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180572(4-(4-bromo-2-fluorophenylamino)-5-fluoro-1-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539753(CHEMBL4648056)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539763(Adagrasib | Mrtx-849 | Mrtx849)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180561(4-(4-bromo-2-fluorophenylamino)-5-fluoro-N-hydroxy...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180562(4-(4-bromo-2-fluorophenylamino)-N-(2-hydroxyethoxy...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539757(CHEMBL4648124)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033405(CHEMBL3357659)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033400(CHEMBL3357664)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180563(4-(4-bromo-2-fluorophenylamino)-5-fluoro-1-methyl-...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180556(4-(4-bromo-2-fluorophenylamino)-N-(2-hydroxyethoxy...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180573(4-(4-bromo-2-fluorophenylamino)-N-ethoxy-5-fluoro-...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033405(CHEMBL3357659)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033399(CHEMBL3357665)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180566(4-(4-bromo-2-fluorophenylamino)-N-(cyclopropylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180571(4-(4-bromo-2-fluorophenylamino)-N-(cyclopropylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033411(CHEMBL3357670)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033409(CHEMBL3357668)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180570(4-(4-bromo-2-fluorophenylamino)-5-fluoro-N-methoxy...)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180560(4-(4-bromo-2-fluorophenylamino)-5-chloro-N-(2-hydr...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033398(CHEMBL3357666)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033408(CHEMBL3357656)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033398(CHEMBL3357666)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033399(CHEMBL3357665)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033397(CHEMBL3357667)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033413(CHEMBL3357672)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033412(CHEMBL3357671)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033403(CHEMBL3357661)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetGTPase KRas(Homo sapiens (Human))
Array BioPharma Inc

Curated by ChEMBL
LigandPNGBDBM50539758(CHEMBL4640234)copy SMILEScopy InChI
Affinity DataIC50: 64nMAssay Description:Inhibition of KRAS G12C mutant in human NCI-H358 cells assessed as reduction in ERK phosphorylation incubated for 3 hrs by in-cell western methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G164C5PubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033403(CHEMBL3357661)copy SMILEScopy InChI
Affinity DataIC50: 76nMAssay Description:Inhibition of purified recombinant human BACE1 expressed in CHO cells assessed as uncleaved biotinylated sAPP after 2 hrs by HTRF assayMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033413(CHEMBL3357672)copy SMILEScopy InChI
Affinity DataIC50: 81nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50180569(4-(4-bromo-2-fluorophenylamino)-N-ethoxy-1,5-dimet...)copy SMILEScopy InChI
Affinity DataIC50: 82nMAssay Description:Inhibitory activity aginst MEK1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2571BKQPubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Array BioPharma

Curated by ChEMBL
LigandPNGBDBM50033400(CHEMBL3357664)copy SMILEScopy InChI
Affinity DataIC50: 86nMAssay Description:Inhibition of BACE1 in HEK293 cells expressing swedish double mutant APP assessed as amyloid beta (1 to 40) peptide level after 7 hrs by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2348N0TPubMed
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