Compile Data Set for Download or QSAR
Found 142 with Last Name = 'quesada' and Initial = 'j'
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200622(CHEMBL3917975)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200572(CHEMBL3889955)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200579(CHEMBL3917466)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200569(CHEMBL3946146)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50187693(CHEMBL3186509)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200582(CHEMBL3944813)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200624(CHEMBL3912114)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200650(CHEMBL3926932)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200664(CHEMBL3983022)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200666(CHEMBL3916898)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM109086(US10793535, Cmpd ID 727 | US8604016, 670 | US99382...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50514979(CHEMBL4457936)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200578(CHEMBL3982059)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50514986(CHEMBL4437956)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200651(CHEMBL3964183)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200580(CHEMBL3907343)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200651(CHEMBL3964183)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50514985(CHEMBL4573635)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50514975(CHEMBL4473143)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50150109(CHEMBL3770355)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200622(CHEMBL3917975)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of ATX in human plasma assessed as decrease in hydrolysis of lysophosphatidylcholine by measuring choline release after 24 hrs by horserad...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50514977(CHEMBL4461749)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200572(CHEMBL3889955)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of ATX in human plasma assessed as decrease in hydrolysis of lysophosphatidylcholine by measuring choline release after 24 hrs by horserad...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50514982(CHEMBL4469711)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200661(CHEMBL3907905)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200579(CHEMBL3917466)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of ATX in human plasma assessed as decrease in hydrolysis of lysophosphatidylcholine by measuring choline release after 24 hrs by horserad...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM278400((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50514978(CHEMBL4451434)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200650(CHEMBL3926932)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Inhibition of ATX in human plasma assessed as decrease in hydrolysis of lysophosphatidylcholine by measuring choline release after 24 hrs by horserad...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200570(CHEMBL3953575)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200578(CHEMBL3982059)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of ATX in human plasma assessed as decrease in hydrolysis of lysophosphatidylcholine by measuring choline release after 24 hrs by horserad...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200624(CHEMBL3912114)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of ATX in human plasma assessed as decrease in hydrolysis of lysophosphatidylcholine by measuring choline release after 24 hrs by horserad...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200622(CHEMBL3917975)copy SMILEScopy InChI
Affinity DataIC50: 38nMAssay Description:Inhibition of ATX in human plasma assessed as decrease in LPA C18:1 levels after 24 hrs by horseradish peroxidase/choline oxidase-coupled assayMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200667(CHEMBL3954360)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200569(CHEMBL3946146)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:Inhibition of ATX in human plasma assessed as decrease in hydrolysis of lysophosphatidylcholine by measuring choline release after 24 hrs by horserad...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM278400((2S)-2-Methoxy-2-phenyl-N-[5-[[(3R)-1-pyridazin-3-...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of GLS1 GAC isoform (unknown origin) using glutamine as substrate preincubated for 15 mins followed by substrate addition and measured aft...More data for this Ligand-Target Pair
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM108464(US8604016, 21 | US9938267, Cmpd ID 21)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200663(CHEMBL3934551)copy SMILEScopy InChI
Affinity DataIC50: 52nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50172138(CHEMBL3808443 | US10040788, Example 1(a) | US10294...)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50514990(CHEMBL4448931)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200621(CHEMBL3916907)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50514974(CHEMBL4472367)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200581(CHEMBL3945659)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Inhibition of human recombinant ATX using Rac-1-Palmitoyl-glycero-3-phosphocholine as substrate incubated for 2 hrs using ADHP fluorogenic peroxidase...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Babraham Research Campus

Curated by ChEMBL
LigandPNGBDBM50200664(CHEMBL3983022)copy SMILEScopy InChI
Affinity DataIC50: 99nMAssay Description:Inhibition of ATX in human plasma assessed as decrease in hydrolysis of lysophosphatidylcholine by measuring choline release after 24 hrs by horserad...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DJ5HM1PubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50514989(CHEMBL4444363)copy SMILEScopy InChI
Affinity DataIC50: 99nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of mTORC1 in human U87MG cells assessed as phosphorylated S6 ribosomal protein (Ser235/236) level after 2 hrs by Western blottingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5NBGPubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of mTORC1 in human U87MG cells assessed as phosphorylated S6 ribosomal protein (Ser235/236) level after 2 hrs by Western blottingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5NBGPubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50514991(CHEMBL4594003)copy SMILEScopy InChI
Affinity DataIC50: 114nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QN6B4WPubMed
TargetGlutaminase kidney isoform, mitochondrial(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50400050(CHEMBL2177757 | US10793535, Cmpd ID 1 | US11191732...)copy SMILEScopy InChI
Affinity DataIC50: 135nMAssay Description:Inhibition of recombinant 6His-tagged GLS1 KGA isoform (unknown origin) (63 to 669 residues) expressed in Escherichia coli using glutamine as substra...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
KuDOS Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50310989((5-(2-((2R,6S)-2,6-dimethylmorpholino)-4-morpholin...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of mTORC2 in human U87MG cells assessed as phosphorylated AKT (Ser473) level after 2 hrs by Western blottingMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5NBGPubMed
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