Compile Data Set for Download or QSAR
Found 276 with Last Name = 'ullrich' and Initial = 'j'
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074024((2S,3R)-3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-p...)copy SMILEScopy InChI
Affinity DataKi:  10nMAssay Description:Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074027(3-(4-Methoxy-benzenesulfonyl)-7-phenyl-heptanoic a...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074023(CHEMBL153469 | N-Hydroxy-3-(4-methoxy-benzenesulfo...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074021(3-(4-Methoxy-benzenesulfonyl)-5-phenyl-pentanoic a...)copy SMILEScopy InChI
Affinity DataKi:  30nMAssay Description:Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074022(3-(4-Methoxy-benzenesulfonyl)-3-methyl-7-phenyl-he...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074028(3-(4-Methoxy-benzenesulfonyl)-6-phenyl-hexanoic ac...)copy SMILEScopy InChI
Affinity DataKi:  50nMAssay Description:Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074026(3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-phenyl-he...)copy SMILEScopy InChI
Affinity DataKi:  60nMAssay Description:Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetStromelysin-1(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074021(3-(4-Methoxy-benzenesulfonyl)-5-phenyl-pentanoic a...)copy SMILEScopy InChI
Affinity DataKi:  200nMAssay Description:Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetStromelysin-1(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074023(CHEMBL153469 | N-Hydroxy-3-(4-methoxy-benzenesulfo...)copy SMILEScopy InChI
Affinity DataKi:  300nMAssay Description:Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetStromelysin-1(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074024((2S,3R)-3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-p...)copy SMILEScopy InChI
Affinity DataKi:  500nMAssay Description:Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetStromelysin-1(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074026(3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-phenyl-he...)copy SMILEScopy InChI
Affinity DataKi:  600nMAssay Description:Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetStromelysin-1(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074028(3-(4-Methoxy-benzenesulfonyl)-6-phenyl-hexanoic ac...)copy SMILEScopy InChI
Affinity DataKi:  600nMAssay Description:Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetStromelysin-1(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074027(3-(4-Methoxy-benzenesulfonyl)-7-phenyl-heptanoic a...)copy SMILEScopy InChI
Affinity DataKi:  700nMAssay Description:Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetStromelysin-1(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074022(3-(4-Methoxy-benzenesulfonyl)-3-methyl-7-phenyl-he...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074023(CHEMBL153469 | N-Hydroxy-3-(4-methoxy-benzenesulfo...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074026(3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-phenyl-he...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074024((2S,3R)-3-(4-Methoxy-benzenesulfonyl)-2-methyl-7-p...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074028(3-(4-Methoxy-benzenesulfonyl)-6-phenyl-hexanoic ac...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074022(3-(4-Methoxy-benzenesulfonyl)-3-methyl-7-phenyl-he...)copy SMILEScopy InChI
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074021(3-(4-Methoxy-benzenesulfonyl)-5-phenyl-pentanoic a...)copy SMILEScopy InChI
Affinity DataKi:  4.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074027(3-(4-Methoxy-benzenesulfonyl)-7-phenyl-heptanoic a...)copy SMILEScopy InChI
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074025(3-(3,4-Dimethoxy-benzenesulfonyl)-7-phenyl-heptano...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of matrix metalloproteinase-2 (MMP-2), gelatinase-AMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074025(3-(3,4-Dimethoxy-benzenesulfonyl)-7-phenyl-heptano...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of matrix metalloproteinase-1 (MMP-1), fibroblast collagenase.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetStromelysin-1(Homo sapiens (Human))
Rhône-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50074025(3-(3,4-Dimethoxy-benzenesulfonyl)-7-phenyl-heptano...)copy SMILEScopy InChI
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of matrix metalloproteinase-3 (MMP-3), stromelysin-1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VQ31VCPubMed
TargetProgesterone receptor(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM18627((10S,11S,14S,15S,17R)-17-[4-(dimethylamino)phenyl]...)copy SMILEScopy InChI
Affinity DataIC50: 0.100nMAssay Description:Progesterone receptor antagonist activity based on its ability to block progesterone induced alkaline phosphatase in the human breast cancer cell lin...More data for this Ligand-Target Pair
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541838(CHEMBL4649483)copy SMILEScopy InChI
Affinity DataIC50: 0.380nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330BVPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305075(3-benzyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 0.920nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305072(8-chloro-3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305073(3-benzyl-8-chloro-4-(3-(3-(methylsulfonyl)phenoxy)...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305064(3-(3-(3-(3-methyl-8-(trifluoromethyl)quinolin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541831(CHEMBL4644535)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330BVPubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50317735(3-benzyl-4-(3'-(methylsulfonyl)biphenyl-3-yl)-8-(t...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:Displacement of [3H]T0901317 from LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9XJZPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305070(4-(3-(3-(ethylsulfonyl)phenoxy)phenyl)-3-methyl-8-...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541837(CHEMBL4642848)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330BVPubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50317744(4-(4'-fluoro-3'-(methylsulfonyl)biphenyl-3-yl)-3-m...)copy SMILEScopy InChI
Affinity DataIC50: 1.70nMAssay Description:Displacement of [3H]T0901317 from LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9XJZPubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50317733(3-methyl-4-(3'-(methylsulfonyl)biphenyl-3-yl)-8-(t...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]T0901317 from LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9XJZPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305068(4-(3-(3-(isopropylsulfonyl)phenoxy)phenyl)-3-methy...)copy SMILEScopy InChI
Affinity DataIC50: 1.80nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35107(biarylether amide quinoline, 4g)copy SMILEScopy InChI
Affinity DataIC50: 1.90nM EC50:  138nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2QR4VGVPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305060(4-(3-(3-fluoro-5-(methylsulfonyl)phenoxy)phenyl)-3...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541836(CHEMBL4642780)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330BVPubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305075(3-benzyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRbeta-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM20000(2-(4-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nM EC50:  93nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXR-coated flash plates. Each concentration of test...More data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35094(biarylether alcohol quinoline, 5f)copy SMILEScopy InChI
Affinity DataIC50: 2.10nM EC50:  233nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5M54PubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM20000(2-(4-{3-[3-benzyl-8-(trifluoromethyl)quinolin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2.10nM EC50:  71nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...More data for this Ligand-Target Pair
TargetThrombospondin-1(Homo sapiens)
Southern Research Institute

Curated by ChEMBL
LigandPNGBDBM50541828(CHEMBL4633877)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of TSP1 in human myeloma cells assessed reduction in TGFbeta activity incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2M330BVPubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50317737(3-ethyl-4-(3'-(methylsulfonyl)biphenyl-3-yl)-8-(tr...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Displacement of [3H]T0901317 from LXRbeta ligand binding domainMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2TD9XJZPubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305077(3-methyl-4-(3-(3-(methylsulfonyl)phenoxy)phenyl)-8...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRbeta-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-alpha(Homo sapiens (Human))
Wyeth Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50305067(4-(3-(3-(isopropylsulfonyl)phenoxy)phenyl)-8-(trif...)copy SMILEScopy InChI
Affinity DataIC50: 2.40nMAssay Description:Displacement of [3H]T0901317 from human recombinant LXRalpha-LBDMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2KW5G4BPubMed
TargetOxysterols receptor LXR-beta [154-461](Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM35099(biarylether alcohol quinoline, 5i)copy SMILEScopy InChI
Affinity DataIC50: 2.5nM EC50:  108nMpH: 7.4 T: 2°CAssay Description:Binding reaction was initiated by adding a dilution series of test compound in tracer solution to LXRbeta coated flash plates. Each concentration of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VH5M54PubMed
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