Compile Data Set for Download or QSAR
Found 42 with Last Name = 'wong-roushar' and Initial = 'j'
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))TBA
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)copy SMILEScopy InChI
Affinity DataKi:  880nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMedDrugBank
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))TBA
LigandPNGBDBM50557564(CHEMBL4783397)copy SMILES
Affinity DataKi:  1.07E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))TBA
LigandPNGBDBM50557566(CHEMBL4741259)copy SMILES
Affinity DataKi:  5.15E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))TBA
LigandPNGBDBM50557565(CHEMBL4755197)copy SMILES
Affinity DataKi:  8.03E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))TBA
LigandPNGBDBM50557570(CHEMBL4761741)copy SMILES
Affinity DataKi:  8.37E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))TBA
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)copy SMILEScopy InChI
Affinity DataKi:  9.48E+3nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))TBA
LigandPNGBDBM50557568(CHEMBL4790375)copy SMILES
Affinity DataKi:  1.45E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))TBA
LigandPNGBDBM50557569(CHEMBL4759798)copy SMILES
Affinity DataKi:  1.98E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))TBA
LigandPNGBDBM50557567(CHEMBL4789686)copy SMILES
Affinity DataKi:  2.47E+4nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))TBA
LigandPNGBDBM50027656(CHEBI:63616 | LY-2315 | LY-231514 | PEMETREXED | U...)copy SMILEScopy InChI
Affinity DataKi: >2.00E+5nMAssay Description:Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formatio...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM50557569(CHEMBL4759798)copy SMILES
Affinity DataIC50: 0.240nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50557568(CHEMBL4790375)copy SMILES
Affinity DataIC50: 0.340nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50557569(CHEMBL4759798)copy SMILES
Affinity DataIC50: 0.440nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM50557570(CHEMBL4761741)copy SMILES
Affinity DataIC50: 0.720nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50557564(CHEMBL4783397)copy SMILES
Affinity DataIC50: 0.910nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50557570(CHEMBL4761741)copy SMILES
Affinity DataIC50: 1.10nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM50557564(CHEMBL4783397)copy SMILES
Affinity DataIC50: 1.20nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM50557566(CHEMBL4741259)copy SMILES
Affinity DataIC50: 1.70nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM50557568(CHEMBL4790375)copy SMILES
Affinity DataIC50: 1.80nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM50557567(CHEMBL4789686)copy SMILES
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50557566(CHEMBL4741259)copy SMILES
Affinity DataIC50: 2.60nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM50557565(CHEMBL4755197)copy SMILES
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50557565(CHEMBL4755197)copy SMILES
Affinity DataIC50: 5.60nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50557567(CHEMBL4789686)copy SMILES
Affinity DataIC50: 11nMAssay Description:Inhibition of human FRalpha expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTite...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetFolate receptor beta(Homo sapiens (Human))TBA
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of human FRbeta expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetProton-coupled folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557570(CHEMBL4761741)copy SMILES
Affinity DataIC50: 80nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetProton-coupled folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557569(CHEMBL4759798)copy SMILES
Affinity DataIC50: 107nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetProton-coupled folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557565(CHEMBL4755197)copy SMILES
Affinity DataIC50: 460nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetReduced folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557565(CHEMBL4755197)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetReduced folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557564(CHEMBL4783397)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetReduced folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557566(CHEMBL4741259)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetReduced folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557567(CHEMBL4789686)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetReduced folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557568(CHEMBL4790375)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetReduced folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557569(CHEMBL4759798)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetReduced folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557570(CHEMBL4761741)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetReduced folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human RFC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-bl...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetProton-coupled folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50249877((S)-2-(4-(4-(2-amino-4-oxo-3,4-dihydrothieno[2,3-d...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetProton-coupled folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557567(CHEMBL4789686)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetProton-coupled folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557568(CHEMBL4790375)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetProton-coupled folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557564(CHEMBL4783397)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed
TargetProton-coupled folate transporter(Homo sapiens (Human))TBA
LigandPNGBDBM50557566(CHEMBL4741259)copy SMILES
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human PCFT expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in cell proliferation after 96 hrs by CellTiter-b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RF5ZQTPubMed