Compile Data Set for Download or QSAR
Found 88 with Last Name = 'kaizerman' and Initial = 'ja'
TargetSmoothened homolog(Mus musculus)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)copy SMILEScopy InChI
Affinity DataIC50: 0.00200nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320340((R)-(3-methyl-4-(4-p-tolylphthalazin-1-yl)piperazi...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Mus musculus)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50323147((R)-(3-methyl-4-(1-(4-(trifluoromethyl)phenyl)pyri...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320341((R)-(4-(4-(4-chlorophenyl)phthalazin-1-yl)-3-methy...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323147((R)-(3-methyl-4-(1-(4-(trifluoromethyl)phenyl)pyri...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320358((R)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320339((R)-(4-(4-(4-cyclopropylphenyl)phthalazin-1-yl)-3-...)copy SMILEScopy InChI
Affinity DataIC50: 2.30nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320336((R)-(4-(4-(4-(hydroxymethyl)phenyl)phthalazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 2.70nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320369((R)-(3-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)copy SMILEScopy InChI
Affinity DataIC50: 2.80nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Mus musculus)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50323146((R)-(3-methyl-4-(1-phenylpyrido[3,4-d]pyridazin-4-...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Antagonist activity at mouse cloned Smo receptor expressed in NIH-3T3 cells co expressing Gli1 binding site after 15 hrs by luciferase reporter gene ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320335((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)copy SMILEScopy InChI
Affinity DataIC50: 3.10nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320345((S)-(2-methyl-4-(4-p-tolylphthalazin-1-yl)piperazi...)copy SMILEScopy InChI
Affinity DataIC50: 3.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323132((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320342((S)-(2-methyl-4-(4-(4-(trifluoromethyl)phenyl)phth...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320355(CHEMBL1085503 | phenyl(4-(4-p-tolylphthalazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 4.40nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323133((R)-2-(4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phth...)copy SMILEScopy InChI
Affinity DataIC50: 4.80nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320356((4-(4-(4-chlorophenyl)phthalazin-1-yl)piperazin-1-...)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320334((R)-(4-(4-(4-(dimethylamino)phenyl)phthalazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 5.20nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320334((R)-(4-(4-(4-(dimethylamino)phenyl)phthalazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320359((S)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320361((S)-(2-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)copy SMILEScopy InChI
Affinity DataIC50: 5.30nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323146((R)-(3-methyl-4-(1-phenylpyrido[3,4-d]pyridazin-4-...)copy SMILEScopy InChI
Affinity DataIC50: 5.80nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50352936(CHEMBL1824915)copy SMILEScopy InChI
Affinity DataIC50: 6.40nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MRKPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320344((S)-(4-(4-(4-chlorophenyl)phthalazin-1-yl)-2-methy...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50352935(CHEMBL1824916)copy SMILEScopy InChI
Affinity DataIC50: 7.20nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MRKPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320338((R)-(4-(4-(4-isopropylphenyl)phthalazin-1-yl)-3-me...)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323138((R)-(4-(4-(indolin-1-yl)phthalazin-1-yl)-3-methylp...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323137((R)-(4-(4-(1H-pyrrol-1-yl)phthalazin-1-yl)-3-methy...)copy SMILEScopy InChI
Affinity DataIC50: 8.70nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320364((4-(4-phenylphthalazin-1-yl)piperazin-1-yl)(thiazo...)copy SMILEScopy InChI
Affinity DataIC50: 9.5nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320337((R)-(4-(4-(4-tert-butylphenyl)phthalazin-1-yl)-3-m...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320359((S)-(3-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320353((4-(4-(4-fluorophenyl)phthalazin-1-yl)piperazin-1-...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323145((R)-(3-methyl-4-(4-phenylpyrido[4,3-d]pyridazin-1-...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323128((S)-(4-(4-(4-fluorophenyl)phthalazin-1-yl)-3-methy...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320343((S)-(4-(4-(4-fluorophenyl)phthalazin-1-yl)-2-methy...)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320360((R)-(2-methyl-4-(4-phenylphthalazin-1-yl)piperazin...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50352948(CHEMBL1824904)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MRKPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320365(CHEMBL1083103 | furan-2-yl(4-(4-phenylphthalazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50352947(CHEMBL1824905)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human SMO expressed in HEPM cells assessed as reduction of GLI expression after 24 hrs by Quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MRKPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320354((4-(4-(4-methoxyphenyl)phthalazin-1-yl)piperazin-1...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320350(CHEMBL1082387 | phenyl(4-(4-o-tolylphthalazin-1-yl...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323144((R)-(3-methyl-4-(5-phenylpyrido[2,3-d]pyridazin-8-...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320357((4-(4-(3,4-dichlorophenyl)phthalazin-1-yl)piperazi...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320357((4-(4-(3,4-dichlorophenyl)phthalazin-1-yl)piperazi...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of human SMO expressed in HEPM cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WQ03ZQPubMed
TargetSmoothened homolog(Mus musculus)
Amgen, Inc.

Curated by ChEMBL
LigandPNGBDBM50352943(CHEMBL1824909)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Antagonist activity at mouse SMO expressed in NIH/3T3 cells transfected with Gli-dependent luciferase-reporter after 15 hrs by luciferase reporter ge...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MRKPubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50323129((R)-4-(4-(4-benzoyl-2-methylpiperazin-1-yl)phthala...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
TargetSmoothened homolog(Homo sapiens (Human))
AMGEN

Curated by ChEMBL
LigandPNGBDBM50320362(CHEMBL1082791 | phenyl(4-(4-phenylphthalazin-1-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Antagonist activity at human Smo receptor in HEPM cells assessed as inhibition of Gli expression after 24 hrs by quantigene assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2H13268PubMed
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