Compile Data Set for Download or QSAR
Found 89 with Last Name = 'salmeron' and Initial = 'ja'
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264866(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251532(4-(carbamimidoyl)-N-(3,4-dimethoxyphenyl)-2-phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251606(CHEMBL479359 | N-(4-chlorophenyl)-4-[N'-cyano-N-(q...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264865((4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-yl...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251637(CHEMBL519095 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264773(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251638(CHEMBL480700 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251606(CHEMBL479359 | N-(4-chlorophenyl)-4-[N'-cyano-N-(q...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251604(CHEMBL479358 | N-(4-chlorophenyl)-4-[N'-cyano-N-(2...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251680(4-[N'-cyano-N-(1,2,3,4-tetrahydroquinolin-5-yl)car...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251607(4-(carbamimidoyl)-N-(4-chlorophenyl)-2-isopropylpi...)copy SMILEScopy InChI
Affinity DataIC50: 67nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265350(4-(4'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 90nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251607(4-(carbamimidoyl)-N-(4-chlorophenyl)-2-isopropylpi...)copy SMILEScopy InChI
Affinity DataIC50: 93nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251717(CHEMBL520580 | N-(4-chlorophenyl)-4-[N'-cyano-N-(2...)copy SMILEScopy InChI
Affinity DataIC50: 93nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251533(CHEMBL518308 | N-(4-chlorophenyl)-4-(N'-cyano-N-o-...)copy SMILEScopy InChI
Affinity DataIC50: 95nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251637(CHEMBL519095 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251715(CHEMBL481483 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251605(4-(carbamimidoyl)-N-(4-chlorophenyl)-2-isopropylpi...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251605(4-(carbamimidoyl)-N-(4-chlorophenyl)-2-isopropylpi...)copy SMILEScopy InChI
Affinity DataIC50: 112nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264739(4-(3'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251604(CHEMBL479358 | N-(4-chlorophenyl)-4-[N'-cyano-N-(2...)copy SMILEScopy InChI
Affinity DataIC50: 125nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265353(4-(4'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251638(CHEMBL480700 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264866(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of COT (unknown origin) by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251533(CHEMBL518308 | N-(4-chlorophenyl)-4-(N'-cyano-N-o-...)copy SMILEScopy InChI
Affinity DataIC50: 132nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50234969(CHEMBL402832 | N'-cyano-4-(2-(3,4-dimethoxyphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 140nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264738(4-(2'-chlorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM28042(5-[4-(4-phenylphenoxy)thieno[2,3-c]pyridin-2-yl]-1...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251717(CHEMBL520580 | N-(4-chlorophenyl)-4-[N'-cyano-N-(2...)copy SMILEScopy InChI
Affinity DataIC50: 151nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264740(4-(4'-fluorobiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251532(4-(carbamimidoyl)-N-(3,4-dimethoxyphenyl)-2-phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 178nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251715(CHEMBL481483 | N-(4-chlorophenyl)-4-[N'-cyano-N-(1...)copy SMILEScopy InChI
Affinity DataIC50: 180nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264741(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)copy SMILEScopy InChI
Affinity DataIC50: 230nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265352(4-(3'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)copy SMILEScopy InChI
Affinity DataIC50: 240nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251639(4-[N'-cyano-N-(1H-indazol-4-yl)carbamimidoyl]-N-(3...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264742(2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphen...)copy SMILEScopy InChI
Affinity DataIC50: 280nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251534(4-(carbamimidoyl)-N-(4-chlorophenyl)-N-methyl-2-ph...)copy SMILEScopy InChI
Affinity DataIC50: 290nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265351(4'-(2-(2H-tetrazol-5-yl)thieno[2,3-c]pyridin-4-ylo...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251564(4-(1-(o-toluidino)-2-nitrovinyl)-N-(4-chlorophenyl...)copy SMILEScopy InChI
Affinity DataIC50: 310nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265349(4-(2'-methoxybiphenyl-4-yloxy)-2-(2H-tetrazol-5-yl...)copy SMILEScopy InChI
Affinity DataIC50: 320nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265275(4-(4-iodophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3-c...)copy SMILEScopy InChI
Affinity DataIC50: 410nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251677(CHEMBL479577 | N-(4-chlorophenyl)-4-(N'-cyano-N-{2...)copy SMILEScopy InChI
Affinity DataIC50: 480nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265276(CHEMBL498592 | N-hydroxy-4-(4-iodophenoxy)thieno[2...)copy SMILEScopy InChI
Affinity DataIC50: 540nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251535(4-(4-chlorophenylsulfonyl)-N'-cyano-3-phenyl-N-o-t...)copy SMILEScopy InChI
Affinity DataIC50: 540nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50264742(2-(2H-tetrazol-5-yl)-4-(4'-(trifluoromethyl)biphen...)copy SMILEScopy InChI
Affinity DataIC50: 560nMAssay Description:Inhibition of COT (unknown origin) by cell-based HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265312(4-(4-tert-butylphenoxy)-2-(2H-tetrazol-5-yl)thieno...)copy SMILEScopy InChI
Affinity DataIC50: 610nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Rattus norvegicus (Rat))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251566(CHEMBL21149 | N1-(4-chlorophenyl)-2-phenyl-N4-o-to...)copy SMILEScopy InChI
Affinity DataIC50: 620nMAssay Description:Antagonist activity at rat recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50234969(CHEMBL402832 | N'-cyano-4-(2-(3,4-dimethoxyphenyl)...)copy SMILEScopy InChI
Affinity DataIC50: 630nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50265311(4-(4-chlorophenoxy)-2-(2H-tetrazol-5-yl)thieno[2,3...)copy SMILEScopy InChI
Affinity DataIC50: 710nMAssay Description:Inhibition of human recombinant COT by HTRF-based assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23J3CTHPubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Abbott Bioresearch Center

Curated by ChEMBL
LigandPNGBDBM50251566(CHEMBL21149 | N1-(4-chlorophenyl)-2-phenyl-N4-o-to...)copy SMILEScopy InChI
Affinity DataIC50: 780nMAssay Description:Antagonist activity at human recombinant P2X7 receptor assessed as inhibition of BzATP induced calcium flux by FLIPR assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4PFNPubMed
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