Compile Data Set for Download or QSAR
Found 192 with Last Name = 'silverman' and Initial = 'ja'
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc

Curated by ChEMBL
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HXMPubMed
LigandPNGBDBM50333919((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
TargetIntegrin alpha-L(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50324826((2S)-2-(2,6-dichloro-4-(3-hydroxy-3-(3-hydroxyphen...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibition of LFA1 by ELISAMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MKBPubMed
LigandPNGBDBM50386338(CHEMBL2048036)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
TargetIntercellular adhesion molecule 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50386331(CHEMBL2048028)copy SMILEScopy InChI
Affinity DataIC50: 2.98nMAssay Description:Inhibition of human recombinant ICAM-1 adhesion into human Jurkat cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
LigandPNGBDBM50386328(CHEMBL2048025)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26333(1-[3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 4nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q279430NPubMed
LigandPNGBDBM50386325(CHEMBL2048402)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc

Curated by ChEMBL
LigandPNGBDBM50324822((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HXMPubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc

Curated by ChEMBL
LigandPNGBDBM50333915((S)-2-(2-(benzofuran-2-carbonyl)-5,7-dichloro-1,2,...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HXMPubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50310621(CHEMBL1079538 | N-(4-(6-(trifluoromethyl)-3H-imida...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72HK2PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50324824((S)-2-(2-(benzofuran-2-carbonyl)-5,7-dichloro-1,2,...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MKBPubMed
LigandPNGBDBM50386326(CHEMBL2048024)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50310608(CHEMBL1077729 | N-(4-(5-(trifluoromethyl)-1H-benzo...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72HK2PubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc

Curated by ChEMBL
LigandPNGBDBM50333917((S)-2-(5,7-dichloro-2-(pyrazolo[1,5-a]pyridine-2-c...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HXMPubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50310607(CHEMBL1078060 | N-(4-(5-chloro-1H-benzo[d]imidazol...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72HK2PubMed
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26322(1-(3-methylphenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q279430NPubMed
LigandPNGBDBM50386331(CHEMBL2048028)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26326(1-(3-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 9nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50324822((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MKBPubMed
TargetAurora kinase A(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM26326(1-(3-chlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of Aurora A after 60 minsMore data for this Ligand-Target Pair
LigandPNGBDBM50386324(CHEMBL2048033)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50310620(CHEMBL1079713 | N-(4-(6-chloro-3H-imidazo[4,5-b]py...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72HK2PubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50324810((S)-2-(5,7-dichloro-2-(4-methylbenzoyl)-1,2,3,4-te...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MKBPubMed
LigandPNGBDBM50386344(CHEMBL2048407)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
LigandPNGBDBM50386334(CHEMBL2048031)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
LigandPNGBDBM50386341(CHEMBL2048404)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50310614(CHEMBL1078906 | N-(4-(1H-benzo[d]imidazol-2-ylamin...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72HK2PubMed
LigandPNGBDBM50386327(CHEMBL2048023)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26330(1-(3-chloro-4-fluorophenyl)-3-[5-(2-{thieno[3,2-d]...)copy SMILEScopy InChI
Affinity DataIC50: 11nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q279430NPubMed
LigandPNGBDBM50386343(CHEMBL2048406)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
LigandPNGBDBM50386340(CHEMBL2048403)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM26329(1-(3,4-dichlorophenyl)-3-[5-(2-{thieno[3,2-d]pyrim...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q279430NPubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50324823((S)-2-(5,7-dichloro-2-(2,3-dihydrobenzofuran-6-car...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MKBPubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM26315(3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q279430NPubMed
LigandPNGBDBM50386345(CHEMBL2048408)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Antagonist activity at LFA-1/ICAM-1 in human HuT-78 T-cells assessed as inhibition of cell adhesion after 1 hr by p-nitrophenyl n-acetyl-beta-D-gluco...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2BV7HP5PubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM26315(3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72HK2PubMed
TargetAurora kinase A(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50310621(CHEMBL1079538 | N-(4-(6-(trifluoromethyl)-3H-imida...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of Aurora A after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72HK2PubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM26325(1-(3-fluorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q279430NPubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM26331(1-1H-indol-7-yl-3-[5-(2-{thieno[3,2-d]pyrimidin-4-...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q279430NPubMed
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc

Curated by ChEMBL
LigandPNGBDBM50333916((S)-2-(2-(benzofuran-6-carbonyl)-5,7-dichloro-1,2,...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HXMPubMed
TargetAurora kinase A(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50310620(CHEMBL1079713 | N-(4-(6-chloro-3H-imidazo[4,5-b]py...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inhibition of Aurora A after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72HK2PubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50310622(CHEMBL1078061 | N-(3-fluoro-4-(5-(trifluoromethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of Aurora B after 60 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T72HK2PubMed
TargetAurora kinase B(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM26333(1-[3-(pyrrolidin-1-ylmethyl)-5-(trifluoromethyl)ph...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q279430NPubMed
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26315(3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 22nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
TargetIntegrin alpha-L/beta-2(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc

Curated by ChEMBL
LigandPNGBDBM50324812((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WW7HXMPubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50324812((S)-2-(5,7-dichloro-2-(4-chlorobenzoyl)-1,2,3,4-te...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MKBPubMed
TargetAurora kinase A(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM26315(3-[5-(2-{thieno[3,2-d]pyrimidin-4-ylamino}ethyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of Aurora A after 60 minsMore data for this Ligand-Target Pair
TargetAurora kinase A(Mus musculus (mouse))
Sunesis Pharmaceuticals

LigandPNGBDBM26325(1-(3-fluorophenyl)-3-[5-(2-{thieno[3,2-d]pyrimidin...)copy SMILEScopy InChI
Affinity DataIC50: 23nMpH: 7.2 T: 2°CAssay Description:Compounds were diluted into assay buffer containing Aurora kinase and FAM-PKAtide. The kinase reaction was initiated by adding ATP in assay buffer. T...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q279430NPubMed
TargetIntegrin beta-2/Intercellular adhesion molecule 1(Homo sapiens (Human))
Sunesis Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50324806((S,E)-2-(5,7-dichloro-2-(3-(furan-2-yl)acryloyl)-1...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Inhibition of LFA1/ICAM1 interaction in human Hut-78 cells by cell migration assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N58MKBPubMed
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