Compile Data Set for Download or QSAR
Found 57 with Last Name = 'bolen' and Initial = 'jb'
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataKi:  0.300nMAssay Description:Competitive inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells in presence of ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataKi:  7nMAssay Description:Competitive inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells in presence of ATPMore data for this Ligand-Target Pair
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse recombinant Aurora A kinase expressed in insect Sf9 cells by radioactive flashplate assayMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50097413(CHEMBL3586473)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase A(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50097413(CHEMBL3586473)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50097414(CHEMBL3586468)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase A(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:Inhibition of Aurora A Thr288 autophosphorylation in human HeLa cells after 1 hrMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50097413(CHEMBL3586473)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Binding affinity to GABAA alpha-1 benzodiazepine binding site (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase A(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50097414(CHEMBL3586468)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase B(Mus musculus)
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 172nMAssay Description:Inhibition of mouse recombinant Aurora B kinase expressed in insect Sf9 cells by radioactive flashplate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B03CSPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50029222(7,8-Dihydroxy-isoquinoline-3-carboxylic acid methy...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 330nMAssay Description:Binding affinity to GABAA alpha-1 benzodiazepine binding site (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 490nMAssay Description:Binding affinity to GABAA alpha-1 benzodiazepine binding site (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50046762(7,8-Dihydroxy-isoquinoline-3-carboxylic acid amide...)copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
TargetAurora kinase B(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50277545(4-(9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-benzo[...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of aurora kinase B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase A(Mus musculus (mouse))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50097418(CHEMBL41816)copy SMILEScopy InChI
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase B(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50097413(CHEMBL3586473)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of aurora kinase B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM3973(N-[(E)-2-(2,5-dihydroxyphenyl)ethenyl]formamide | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2PWJ
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of LCK by radioactive flashplate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B03CSPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2PWJ
TargetAurora kinase B(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of aurora kinase B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetAurora kinase B(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of Aurora B Ser10 phosphorylation in human HeLa cells after 1 hrMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B03CSPubMed
TargetAurora kinase A(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50097418(CHEMBL41816)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50279860(CHEMBL46946 | N-(3,4-dihydroxystyryl)formamide | N...)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2PWJ
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+3nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2PWJ
TargetAurora kinase B(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50097418(CHEMBL41816)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora kinase B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50279861((E)-2-Cyano-3-(2,5-dihydroxy-phenyl)-acrylamide | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Epidermal growth factor receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2PWJ
TargetAurora kinase B(Homo sapiens (Human))
Takeda Pharmaceuticals International Co. , 40 Landsdowne Street, Cambridge, Massachusetts 02139, United States.

Curated by ChEMBL
LigandPNGBDBM50097414(CHEMBL3586468)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of aurora kinase B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence analysisMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WS8W1VPubMed
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 2.05E+4nMAssay Description:Inhibition of CK2 by radioactive flashplate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B03CSPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+4nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM4301((2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide...)copy SMILEScopy InChI
Affinity DataIC50: 2.20E+4nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50029224(5,6-Dihydroxy-naphthalene-2-carboxylic acid methyl...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50046763(6,7-Dihydroxy-naphthalene-2-carboxylic acid amide ...)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+4nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of CHK2 by radioactive flashplate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B03CSPubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of PLK1 by radioactive flashplate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B03CSPubMed
TargetCyclin-dependent kinase 1(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CDK1 by radioactive flashplate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B03CSPubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Millennium Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM31093(4-[[7-[2,6-bis(fluoranyl)phenyl]-9-chloranyl-5H-py...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CHK1 by radioactive flashplate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25B03CSPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50046761(6-Hydroxy-2-imino-2H-chromene-3-carboxylic acid am...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50046758(8-Hydroxy-2-imino-2H-chromene-3-carboxylic acid am...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50279861((E)-2-Cyano-3-(2,5-dihydroxy-phenyl)-acrylamide | ...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of p56 lck tyrosine kinaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WH2PWJ
TargetInsulin receptor(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50011995((Hydroxy-naphthalen-2-yl-methyl)-phosphonic acid |...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of insulin receptor autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K0737XPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50011995((Hydroxy-naphthalen-2-yl-methyl)-phosphonic acid |...)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibition of Epidermal growth factor receptor autophosphorylation in A431 cell membranesMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2K0737XPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50046755(2-Cyano-3-(3,5-dihydroxy-phenyl)-acrylamide | CHEM...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+5nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50046754(6,7-Dihydroxy-quinoline-3-carboxylic acid amide | ...)copy SMILEScopy InChI
Affinity DataIC50: 6.10E+5nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50029220(7,8-Dihydroxy-2-imino-2H-chromene-3-carboxylic aci...)copy SMILEScopy InChI
Affinity DataIC50: 7.50E+5nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
National Cancer Institute

Curated by ChEMBL
LigandPNGBDBM4355((2E)-2-cyano-3-(4-hydroxyphenyl)prop-2-enamide | C...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+6nMAssay Description:Ability to inhibit autophosphorylation of immunopurified p56IckMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2CV4GTQPubMed
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