Affinity DataIC50: 0.0240nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0240nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Antagonist activity at GR in human HepG2 cells assessed as inhibition of protein mediated-transcriptional activity by MMTV-promoter driven luciferase...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0300nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0450nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0510nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0550nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0590nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0700nMAssay Description:Antagonist activity at GR in human HepG2 cells assessed as inhibition of protein mediated-transcriptional activity by MMTV-promoter driven luciferase...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0760nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 0.280nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 0.400nMAssay Description:Antagonist activity at GR in human HepG2 cells assessed as inhibition of protein mediated-transcriptional activity by MMTV-promoter driven luciferase...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Antagonist activity at GR in human HepG2 cells assessed as inhibition of protein mediated-transcriptional activity by MMTV-promoter driven luciferase...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Antagonist activity at GR in human HepG2 cells assessed as inhibition of protein mediated-transcriptional activity by MMTV-promoter driven luciferase...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HepG2 cells assessed as inhibition of 17beta-estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HepG2 cells assessed as inhibition of 17beta-estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HepG2 cells assessed as inhibition of 17beta-estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HepG2 cells assessed as inhibition of 17beta-estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 6.31nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HepG2 cells assessed as inhibition of 17beta-estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
Affinity DataIC50: 7.60nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 7.94nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Affinity DataIC50: 9nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HepG2 cells assessed as inhibition of 17beta-estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
Affinity DataIC50: 9.40nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
Affinity DataIC50: 9.5nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
Affinity DataIC50: 9.60nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 9.60nMAssay Description:Induction of ERalpha degradation in human MCF7 cells after 4 hrs by Alexafluor-488 conjugate anti-mouse IgG antibody/Hoechst 33342 staining based imm...More data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HepG2 cells assessed as inhibition of 17beta-estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HepG2 cells assessed as inhibition of 17beta-estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HepG2 cells assessed as inhibition of 17beta-estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HepG2 cells assessed as inhibition of 17beta-estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
TargetEukaryotic translation initiation factor 2-alpha kinase 1(Homo sapiens (Human))
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Johnson& Johnson Pharmaceutical Research and Development
Curated by ChEMBL
Affinity DataIC50: 19.9nMAssay Description:Inhibition of human HRI kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of HDAC in human HeLa nuclear extracts using Boc-Lys (acetyl)-AMC as substrate preincubated for 5 mins followed by substrate addition and ...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
TargetEstrogen receptor beta(Homo sapiens (Human))
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (Wuhan University)
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Antagonist activity at ERbeta (unknown origin) expressed in human HepG2 cells assessed as inhibition of 17beta-estradiol-induced transcriptional acti...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human C-terminal FLAG/His-tagged HDAC1 (1 to 482 residues) expressed in Sf9 insect cells using fluor de lys SIRT1 as substr...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(Ac)-AMC as s...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of N-terminal GST-tagged full length human HDAC6 expressed in baculovirus-infected Sf9 cells using Boc-Lys (acetyl)-AMC as substrate prein...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of recombinant human full-length N-terminal GST-tagged HDAC6 expressed in baculovirus infected Sf9 insect cells using Boc-Lys(Ac)-AMC as s...More data for this Ligand-Target Pair