Affinity DataKi: 47nMAssay Description:Inhibition of human liver cathepsin L assessed as inhibition constant using Z-Phe-Arg-AMC as substrate measured every 5 mins for 1 hr by fluorescence...More data for this Ligand-Target Pair
Affinity DataKi: 64nMAssay Description:Inhibition of human liver cathepsin B assessed as inhibition constant using Z-Arg-Arg-AMC as substrate measured every 5 mins for 1 hr by fluorescence...More data for this Ligand-Target Pair
Affinity DataKi: 76nMAssay Description:Inhibition of human liver cathepsin L assessed as inhibition constant using Z-Phe-Arg-AMC as substrate measured every 5 mins for 1 hr by fluorescence...More data for this Ligand-Target Pair
Affinity DataKi: 110nMAssay Description:Inhibition of human liver cathepsin B assessed as inhibition constant using Z-Arg-Arg-AMC as substrate measured every 5 mins for 1 hr by fluorescence...More data for this Ligand-Target Pair
TargetNeurotensin receptor type 1(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 60nMAssay Description:Displacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamm...More data for this Ligand-Target Pair
TargetNeurotensin receptor type 1(Homo sapiens (Human))
University of Nebraska Medical Center
Curated by ChEMBL
University of Nebraska Medical Center
Curated by ChEMBL
Affinity DataIC50: 63nMAssay Description:Displacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamm...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of TNFalpha-induced IKKbeta mediated NF-kappaB activation in human Pancreatic cancer cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of TNFalpha-induced IKKbeta mediated NF-kappaB activation in human Pancreatic cancer cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPAC2 expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine nucleotide exchange ac...More data for this Ligand-Target Pair
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Affinity DataIC50: 2.23E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPAC2 expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine nucleotide exchange ac...More data for this Ligand-Target Pair
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Affinity DataIC50: 3.13E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Institute for Research in Cancer and Allied Diseases
Curated by ChEMBL
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
![](/img/powered_by_small.gif)