Compile Data Set for Download or QSAR
Found 14 with Last Name = 'garrison' and Initial = 'jc'
TargetProcathepsin L(Homo sapiens (Human))
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50513376(CHEMBL4443064)copy SMILEScopy InChI
Affinity DataKi:  47nMAssay Description:Inhibition of human liver cathepsin L assessed as inhibition constant using Z-Phe-Arg-AMC as substrate measured every 5 mins for 1 hr by fluorescence...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9F3KPubMed
TargetCathepsin B(Homo sapiens (Human))
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50513376(CHEMBL4443064)copy SMILEScopy InChI
Affinity DataKi:  64nMAssay Description:Inhibition of human liver cathepsin B assessed as inhibition constant using Z-Arg-Arg-AMC as substrate measured every 5 mins for 1 hr by fluorescence...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9F3KPubMed
TargetProcathepsin L(Homo sapiens (Human))
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50513377(CHEMBL4588311)copy SMILEScopy InChI
Affinity DataKi:  76nMAssay Description:Inhibition of human liver cathepsin L assessed as inhibition constant using Z-Phe-Arg-AMC as substrate measured every 5 mins for 1 hr by fluorescence...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9F3KPubMed
TargetCathepsin B(Homo sapiens (Human))
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50513377(CHEMBL4588311)copy SMILEScopy InChI
Affinity DataKi:  110nMAssay Description:Inhibition of human liver cathepsin B assessed as inhibition constant using Z-Arg-Arg-AMC as substrate measured every 5 mins for 1 hr by fluorescence...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9F3KPubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50513377(CHEMBL4588311)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Displacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamm...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9F3KPubMed
TargetNeurotensin receptor type 1(Homo sapiens (Human))
University of Nebraska Medical Center

Curated by ChEMBL
LigandPNGBDBM50513378(CHEMBL4528094)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Displacement of [177Lu] DOTA-beta-ala-[N-alpha-Me8, Dmt11, Tle12] NT6-13 from neurotensin receptor in human HT-29 cells incubated for 45 mins by gamm...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21J9F3KPubMed
LigandPNGBDBM50572632(CHEMBL1760195)copy SMILES
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of TNFalpha-induced IKKbeta mediated NF-kappaB activation in human Pancreatic cancer cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DZ0D39PubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280395(CHEMBL4171480)copy SMILEScopy InChI
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4Z83PubMed
LigandPNGBDBM50572633(CHEMBL4865581)copy SMILES
Affinity DataIC50: 8.40E+3nMAssay Description:Inhibition of TNFalpha-induced IKKbeta mediated NF-kappaB activation in human Pancreatic cancer cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DZ0D39PubMed
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280396(CHEMBL4160863)copy SMILEScopy InChI
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPAC2 expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine nucleotide exchange ac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4Z83PubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280394(CHEMBL4168137)copy SMILEScopy InChI
Affinity DataIC50: 1.76E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4Z83PubMed
TargetRap guanine nucleotide exchange factor 4(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280395(CHEMBL4171480)copy SMILEScopy InChI
Affinity DataIC50: 2.23E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPAC2 expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine nucleotide exchange ac...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4Z83PubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280396(CHEMBL4160863)copy SMILEScopy InChI
Affinity DataIC50: 3.13E+4nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4Z83PubMed
TargetRap guanine nucleotide exchange factor 3(Homo sapiens (Human))
Institute for Research in Cancer and Allied Diseases

Curated by ChEMBL
LigandPNGBDBM50280397(CHEMBL4175985)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged EPAC1 (149 to 881 residues) expressed in Escherichia coli Rosetta 2(DE3) assessed as reduction in guanine ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20C4Z83PubMed