Found 200 with Last Name = 'boylan' and Initial = 'jf' TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 G2019S mutant catalytic domain (970 to 2527 residues) expressed in baculovirus expression system usi...More data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 0.00100nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 catalytic domain (970 to 2527 residues) expressed in baculovirus expression system using LRRKtide as...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0320nMAssay Description:Inhibition of recombinant human full length His-tagged JNK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.0590nMAssay Description:Inhibition of recombinant human full length His-tagged JNK2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 3(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 0.104nMAssay Description:Inhibition of recombinant human full length GST-tagged DYRK3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.107nMAssay Description:Inhibition of recombinant human full length N-terminal GST-tagged JNK3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetTestis-specific serine/threonine-protein kinase 1(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 0.217nMAssay Description:Inhibition of recombinant human full length His-tagged TSSK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 0.261nMAssay Description:Inhibition of recombinant human GST-tagged CLK2 catalytic domain (137 to 498 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.567nMAssay Description:Inhibition of recombinant human GST-tagged LTK cytoplasmic domain (450 to 864 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 0.600nMAssay Description:Inhibition of Kinase Tracer 236 binding to recombinant human full-length GST-tagged TTk expressed in baculovirus expression system measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Kinase Tracer 236 binding to recombinant human full-length GST-tagged TTk expressed in baculovirus expression system measured after 1 h...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 0.700nMAssay Description:Inhibition of Kinase Tracer 236 binding to recombinant human full-length GST-tagged TTk expressed in baculovirus expression system measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 0.900nMAssay Description:Inhibition of full length TTK (unknown origin) using MBP-derived peptide as substrate preincubated for 1 hr in dark followed by substrate addition an...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of Kinase Tracer 236 binding to recombinant human full-length GST-tagged TTk expressed in baculovirus expression system measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of Kinase Tracer 236 binding to recombinant human full-length GST-tagged TTk expressed in baculovirus expression system measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Kinase Tracer 236 binding to recombinant human full-length GST-tagged TTk expressed in baculovirus expression system measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Kinase Tracer 236 binding to recombinant human full-length GST-tagged TTk expressed in baculovirus expression system measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibition of Kinase Tracer 236 binding to recombinant human full-length GST-tagged TTk expressed in baculovirus expression system measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of Kinase Tracer 236 binding to recombinant human full-length GST-tagged TTk expressed in baculovirus expression system measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Inhibition of Kinase Tracer 236 binding to recombinant human full-length GST-tagged TTk expressed in baculovirus expression system measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human full length recombinant GST-tagged TTK expressed in baculovirus by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.60nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human GST-tagged CLK2 expressed in baculovirus by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4/G1/S-specific cyclin-D1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 7nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
Affinity DataIC50: 7.20nMAssay Description:Inhibition of Kinase Tracer 236 binding to recombinant human full-length GST-tagged TTk expressed in baculovirus expression system measured after 1 h...More data for this Ligand-Target Pair
Affinity DataIC50: 7.5nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Inhibition of TTK autophosphorylation in human CAL51 cells by radioimmuno-precipitation assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 9nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
Affinity DataIC50: 9nMAssay Description:Displacement of kinase tracer 236 from TTK (unknown origin) by LanthaScreen Eu kinase binding assayMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 11nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of TTK in human CAL51 cells assessed as decrease in phosphorylated TTK T686 levels after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 13nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 13nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Celgene Corporation
Curated by ChEMBL
Celgene Corporation
Curated by ChEMBL
Affinity DataIC50: 15nMAssay Description:Inhibition of CLK2 in human HCT116 cell lysate after 1 hr by LC-MS/MS analysis relative to controlMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Bristol-Myers Squibb Company
Bristol-Myers Squibb Company
Affinity DataIC50: 15nMAssay Description:The enzyme was assayed with substrate GST-Rb in the presence of 50 uM ATP/[gamma-32P] ATP, and capturing the 32-P labeled reaction products on GSH-Se...More data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of TTK autophosphorylation in human CAL51 cells by radioimmuno-precipitation assayMore data for this Ligand-Target Pair
