Compile Data Set for Download or QSAR
Found 49 with Last Name = 'julias' and Initial = 'jg'
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17667(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17666(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 110nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
NCI-Frederick

Curated by ChEMBL
LigandPNGBDBM50481090(CHEMBL567882)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS-313 cells expressing HSV thymidine kinase assessed as lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026MQPubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
NCI-Frederick

Curated by ChEMBL
LigandPNGBDBM50481091(CHEMBL27473)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of HIV1 reverse transcriptase M184V mutant-mediated viral DNA synthesis in human HOS-313 cells expressing HSV thymidine kinase assessed as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026MQPubMed
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17665(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 200nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17672(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 280nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17668(CHEMBL58494 | N-[2-(2,6-difluorophenyl)-1-[(2,6-di...)copy SMILEScopy InChI
Affinity DataIC50: 320nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
NCI-Frederick

Curated by ChEMBL
LigandPNGBDBM50481090(CHEMBL567882)copy SMILEScopy InChI
Affinity DataIC50: 380nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs befo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026MQPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33960(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 400nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 500nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 500nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33959(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 500nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,Y780C]/[600-1151,Y780C](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 650nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,L699I,K702N,C879S]/[600-1151,L699I,K702N,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
NCI-Frederick

Curated by ChEMBL
LigandPNGBDBM50481091(CHEMBL27473)copy SMILEScopy InChI
Affinity DataIC50: 830nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS-313 cells expressing HSV thymidine kinase assessed as lu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026MQPubMed
TargetGag-Pol polyprotein [600-1028,V705A,Y780C,C879S]/[600-1151,V705A,Y780C,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 850nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33961(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,Y787L]/[600-1151,Y787L](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 1.20E+3nMAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
NCI-Frederick

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs befo...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026MQPubMed
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17673(4-bromo-2-(2,6-difluorophenyl)-1-[(2,6-difluorophe...)copy SMILEScopy InChI
Affinity DataIC50: 1.61E+3nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
NCI-Frederick

Curated by ChEMBL
LigandPNGBDBM50481091(CHEMBL27473)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase M184V mutant-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026MQPubMed
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17670(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 1.88E+3nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33957(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33958(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17674(4-chloro-2-(2,6-difluorophenyl)-1-[(2,6-difluoroph...)copy SMILEScopy InChI
Affinity DataIC50: 2.63E+3nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33958(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+3nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
NCI-Frederick

Curated by ChEMBL
LigandPNGBDBM50481091(CHEMBL27473)copy SMILEScopy InChI
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs befo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026MQPubMed
TargetReverse transcriptase protein(Human immunodeficiency virus 1)
NCI-Frederick

Curated by ChEMBL
LigandPNGBDBM50002692((AZT) 1-(4-Azido-5-hydroxymethyl-tetrahydro-furan-...)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of HIV1 reverse transcriptase M184V mutant-mediated viral DNA synthesis in human HOS cells assessed as luciferase activity treated 3 hrs b...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29026MQPubMed
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17676(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 4.94E+3nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33959(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+3nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33960(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 7.00E+3nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33961(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 7.50E+3nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33956(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+4nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33954(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33955(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMpH: 8.0 T: 2°CAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17669(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 1.75E+4nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33953(dihydroxy benzoyl naphthyl hydrazone (DHBNH))copy SMILEScopy InChI
Affinity DataIC50: 2.50E+4nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17677(2-(2,6-difluorophenyl)-1-[(2,6-difluorophenyl)meth...)copy SMILEScopy InChI
Affinity DataIC50: 4.00E+4nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33954(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33955(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33957(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1028,C879S]/[600-1151,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM33956(dihydroxy benzoyl naphthyl hydrazone (DHBNH) analo...)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMpH: 7.8 T: 2°CAssay Description:HIV-1 RT RDDP activity was generally determined by a fixed time assay. Briefly, reaction mixtures contained p51/p66 RT, template-primer, and [3H]-TTP...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2FF3QQCPubMed
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17675(CHEMBL58358 | N-[2-(2,6-difluorophenyl)-1-[(2,6-di...)copy SMILEScopy InChI
Affinity DataIC50: 5.47E+4nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
TargetGag-Pol polyprotein [600-1029,C879S]/[600-1159,C879S](Human immunodeficiency virus type 1)
NCI-FCRDC

LigandPNGBDBM17671(benzimidazole analogue, 50 | methyl 2-(2,6-difluor...)copy SMILEScopy InChI
Affinity DataIC50: 1.58E+5nMpH: 8.0 T: 2°CAssay Description:The IC50 of reverse transcriptase is the concentration that inhibits 50% of recombinant HIV-1 RT RNA-directed DNA polymerase activity in vitro.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q25M6409PubMed
LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)copy SMILEScopy InChI
Affinity DataAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,L699I,K702N,C879S]/[600-1151,L699I,K702N,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)copy SMILEScopy InChI
Affinity DataAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,V705A,Y780C,C879S]/[600-1151,V705A,Y780C,C879S](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)copy SMILEScopy InChI
Affinity DataAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,Y787L]/[600-1151,Y787L](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)copy SMILEScopy InChI
Affinity DataAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair
TargetGag-Pol polyprotein [600-1028,Y780C]/[600-1151,Y780C](Human immunodeficiency virus type 1)
Rutgers University

LigandPNGBDBM2483((4S)-6-chloro-4-(2-cyclopropylethynyl)-4-(trifluor...)copy SMILEScopy InChI
Affinity DataAssay Description:To assess the effect of inhibitors, RT RNH activity was measured using a FRET-based microplate fluorescence assay. Briefly, the RNA-DNA hybrid duplex...More data for this Ligand-Target Pair