Compile Data Set for Download or QSAR
Found 597 with Last Name = 'acton' and Initial = 'jj'
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002827(1-{3-(3-Hydroxy-propoxy)-2-propoxy-5-[(2S,5S)-5-(3...)copy SMILEScopy InChI
Affinity DataKi:  1.90nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002828(1-{3-(3-Morpholin-4-yl-propoxy)-2-propoxy-5-[(2S,5...)copy SMILEScopy InChI
Affinity DataKi:  2.5nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002824((S)-5-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-tri...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002827(1-{3-(3-Hydroxy-propoxy)-2-propoxy-5-[(2S,5S)-5-(3...)copy SMILEScopy InChI
Affinity DataKi:  2.90nMAssay Description:In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002826(1-{3-(3-Imidazol-1-yl-propoxy)-2-propoxy-5-[(2S,5S...)copy SMILEScopy InChI
Affinity DataKi:  3nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002823(2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...)copy SMILEScopy InChI
Affinity DataKi:  3.20nMAssay Description:In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002824((S)-5-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-tri...)copy SMILEScopy InChI
Affinity DataKi:  3.70nMAssay Description:In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002825((R)-5-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-tri...)copy SMILEScopy InChI
Affinity DataKi:  3.70nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002825((R)-5-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-tri...)copy SMILEScopy InChI
Affinity DataKi:  3.72nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002823(2-{3-Methoxy-2-propoxy-5-[(2S,5S)-5-(3,4,5-trimeth...)copy SMILEScopy InChI
Affinity DataKi:  6.30nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81972((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)copy SMILEScopy InChI
Affinity DataKi:  9nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50366241(CHEMBL297624 | L-652731)copy SMILEScopy InChI
Affinity DataKi:  103nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002822((-)-trans 42s,5S)-2-[3-[(2-Oxopropyl)sulfony1]-4-n...)copy SMILEScopy InChI
Affinity DataKi:  110nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002822((-)-trans 42s,5S)-2-[3-[(2-Oxopropyl)sulfony1]-4-n...)copy SMILEScopy InChI
Affinity DataKi:  174nMAssay Description:In vitro effect on inhibition of the binding of [3H]C18-Platelet activating factor to human PMN membranes preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50002830((2R,3R,4R,5S)-2,5-Bis-(3,4-dimethoxy-phenyl)-3,4-d...)copy SMILEScopy InChI
Affinity DataKi:  1.00E+3nMAssay Description:Inhibition of the binding of [3H]C18-Platelet activating factor to human platelet membrane preparationMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2445N3BPubMed
LigandPNGBDBM620922((3R,4R)-4-(4-(6-chloro-2-((1- cyclopropyl-5-(diflu...)copy SMILES
Affinity DataIC50: 0.0800nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM50584324(CHEMBL5088471)copy SMILES
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of recombinant N-terminal GST-fused LRRK2 G2109S mutant (970 to 2527 residues) (unknown origin) preincubated with enzyme for 15 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RX9GZHPubMed
LigandPNGBDBM620916((3S,4S) or (3R,4R) 4-(4-(6- chloro-2-((5-(difluoro...)copy SMILES
Affinity DataIC50: 0.0800nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620868((3S,4S) or (3R,4R) 4-(4-(6- chloro-2-((5-chloro-1-...)copy SMILES
Affinity DataIC50: 0.0800nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620971((3S,4S) or (3R, 4R)-4-((R) or (S)- 4-(6-chloro-2-(...)copy SMILES
Affinity DataIC50: 0.0880nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620720(US20230303540, Example Ex-3.1)copy SMILES
Affinity DataIC50: 0.0930nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620851(US20230303540, Example Ex-5.1)copy SMILES
Affinity DataIC50: 0.105nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620733(1-{6-chloro-2-[(1-cyclopropyl-5- methyl-1H-pyrazol...)copy SMILES
Affinity DataIC50: 0.106nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620974(US20230303540, Example Ex-13.1 | US20230303540, Ex...)copy SMILES
Affinity DataIC50: 0.116nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620858((3S,4S) or (3R,4R) 4-(4-{2-[(5- chloro-1-cycloprop...)copy SMILES
Affinity DataIC50: 0.170nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620778((3R,4R) or (3S,4S) 4-(4-(6-chloro- 2-((5-chloro-1-...)copy SMILES
Affinity DataIC50: 0.178nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620854((3S,4S) or (3R,4R) 4-(4-(2-((1- cyclopropyl-5-meth...)copy SMILES
Affinity DataIC50: 0.180nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620857((3S,4S) or (3R,4R) 4-(4-{2-[(1- cyclopropyl-5-meth...)copy SMILES
Affinity DataIC50: 0.197nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620875(1-(6-chloro-2-{[1-(2,2-(R) or (S) difluorocyclopro...)copy SMILES
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620779((R or S) 6-chloro-N-(5-chloro-1-((S) or (R) 2,2-d...)copy SMILES
Affinity DataIC50: 0.200nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620868((3S,4S) or (3R,4R) 4-(4-(6- chloro-2-((5-chloro-1-...)copy SMILES
Affinity DataIC50: 0.212nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620734(US20230303540, Example Ex-3.15 | US20230303540, Ex...)copy SMILES
Affinity DataIC50: 0.218nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620731(1-(6-chloro-2-{[1-(2-hydroxy-2- methylpropyl)-1H-p...)copy SMILES
Affinity DataIC50: 0.221nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620734(US20230303540, Example Ex-3.15 | US20230303540, Ex...)copy SMILES
Affinity DataIC50: 0.227nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620977((3S,4S) or (3R, 4R)-4-(4-(2-((1- (bicyclo[1.1.1]pe...)copy SMILES
Affinity DataIC50: 0.267nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620893((3S,4S) or (3R,4R) 4-[4-(6- chloro-2-{[5-chloro-1-...)copy SMILES
Affinity DataIC50: 0.270nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620719((3S,4S or 3R,4R)-N-(1- (bicyclo[1.1.1]pentan-1-yl)...)copy SMILES
Affinity DataIC50: 0.279nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM50609728(CHEMBL5267350)copy SMILES
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM50609742(CHEMBL5286106)copy SMILES
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM50609742(CHEMBL5286106)copy SMILES
Affinity DataIC50: 0.300nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620853((3S,4S) or (3R,4R) 4-(4-(2-((1- (2,2-(R) or (S) di...)copy SMILES
Affinity DataIC50: 0.310nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620884((3S,4S) or (3R,4R) 4-(4-{6- chloro-2-[(1-cycloprop...)copy SMILES
Affinity DataIC50: 0.322nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620887((3S,4S) or (3R,4R) 2-[4-({6- chloro-7-[4-(4-hydrox...)copy SMILES
Affinity DataIC50: 0.323nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620904((3S,4S) or (3R,4R) 4-[4-(6- chloro-2-{[1-(2,2-(R) ...)copy SMILES
Affinity DataIC50: 0.352nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620894((3S,4S) or (3R,4R) 4-(4-{6- chloro-2-[(5-chloro-1-...)copy SMILES
Affinity DataIC50: 0.381nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620751((8-syn)-3-(6-chloro-2-{[1-(2- hydroxy-2-methylprop...)copy SMILES
Affinity DataIC50: 0.393nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM50609741(CHEMBL5284341)copy SMILES
Affinity DataIC50: 0.400nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620856((3S,4S) or (3R,4R) 4-(4-(2-((5- chloro-1-cycloprop...)copy SMILES
Affinity DataIC50: 0.403nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620729(1-(6-chloro-2-{[1-(2-hydroxy-2- methylpropyl)-1H-p...)copy SMILES
Affinity DataIC50: 0.407nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
LigandPNGBDBM620891((3S,4S) or (3R,4R) 4-[4-(6- chloro-2-{[1-(2,2-difl...)copy SMILES
Affinity DataIC50: 0.418nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
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