Compile Data Set for Download or QSAR
Found 78 with Last Name = 'blazel' and Initial = 'jk'
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30448(benzothiazine-containing analog, 3a | pyridazin-3-...)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  1.10nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30458(benzothiazine-containing analog, 3b)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  2.70nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43RFHPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30544(5,6-Dihydro-1H-pyridin-2-one, 4ap)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  55nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30543(5,6-Dihydro-1H-pyridin-2-one, 4ao)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  45nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30542(5,6-Dihydro-1H-pyridin-2-one, 4an)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  34nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30541(5,6-Dihydro-1H-pyridin-2-one, 4am)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  160nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30538(5,6-Dihydro-1H-pyridin-2-one, 4aj)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  9nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30537(5,6-Dihydro-1H-pyridin-2-one, 4ai)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  32nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30452(Hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 3 | hexah...)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  34nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30418(BMCL185002 Compound 3a | BMCL19451 Compound 2 | py...)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  12nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30530(5,6-Dihydro-1H-pyridin-2-one, 4ad)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  16nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30516(5,6-Dihydro-1H-pyridin-2-one, 4p)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  60nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30466(benzothiazine-containing analog, 4a)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  1.5nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43RFHPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30504(5,6-Dihydro-1H-pyridin-2-one, 4d)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  23nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30508(5,6-Dihydro-1H-pyridin-2-one, 4h)copy SMILEScopy InChI
Affinity DataIC50: 10nM EC50:  24nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30460(benzothiazine-containing analog, 3d)copy SMILEScopy InChI
Affinity DataIC50: 15nM EC50:  3.5nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43RFHPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30461(benzothiazine-containing analog, 3e)copy SMILEScopy InChI
Affinity DataIC50: 18nM EC50:  36nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43RFHPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30523(5,6-Dihydro-1H-pyridin-2-one, 4w)copy SMILEScopy InChI
Affinity DataIC50: 20nM EC50:  170nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30505(5,6-Dihydro-1H-pyridin-2-one, 4e)copy SMILEScopy InChI
Affinity DataIC50: 22nM EC50:  150nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30504(5,6-Dihydro-1H-pyridin-2-one, 4d)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30530(5,6-Dihydro-1H-pyridin-2-one, 4ad)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30538(5,6-Dihydro-1H-pyridin-2-one, 4aj)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30516(5,6-Dihydro-1H-pyridin-2-one, 4p)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30418(BMCL185002 Compound 3a | BMCL19451 Compound 2 | py...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30452(Hexahydro-pyrrolo[1,2-b]pyridazin-2-one, 3 | hexah...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30508(5,6-Dihydro-1H-pyridin-2-one, 4h)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30531(5,6-Dihydro-1H-pyridin-2-one, 4ae)copy SMILEScopy InChI
Affinity DataIC50: 26nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30534(5,6-Dihydro-1H-pyridin-2-one, 4af)copy SMILEScopy InChI
Affinity DataIC50: 27nM EC50:  120nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30467(benzothiazine-containing analog, 4b)copy SMILEScopy InChI
Affinity DataIC50: 27nM EC50:  13nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43RFHPubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30544(5,6-Dihydro-1H-pyridin-2-one, 4ap)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30542(5,6-Dihydro-1H-pyridin-2-one, 4an)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30522(5,6-Dihydro-1H-pyridin-2-one, 4v)copy SMILEScopy InChI
Affinity DataIC50: 28nM EC50:  880nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30543(5,6-Dihydro-1H-pyridin-2-one, 4ao)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30531(5,6-Dihydro-1H-pyridin-2-one, 4ae)copy SMILEScopy InChI
Affinity DataIC50: 31nM EC50:  220nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30517(5,6-Dihydro-1H-pyridin-2-one, 4q)copy SMILEScopy InChI
Affinity DataIC50: 35nM EC50:  120nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30459(benzothiazine-containing analog, 3c)copy SMILEScopy InChI
Affinity DataIC50: 39nM EC50:  15nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2T43RFHPubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30510(5,6-Dihydro-1H-pyridin-2-one, 4j)copy SMILEScopy InChI
Affinity DataIC50: 39nM EC50:  22nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30528(5,6-Dihydro-1H-pyridin-2-one, 4ab)copy SMILEScopy InChI
Affinity DataIC50: 40nM EC50:  39nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30506(5,6-Dihydro-1H-pyridin-2-one, 4f)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30535(5,6-Dihydro-1H-pyridin-2-one, 4ag)copy SMILEScopy InChI
Affinity DataIC50: 43nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30509(5,6-Dihydro-1H-pyridin-2-one, 4i)copy SMILEScopy InChI
Affinity DataIC50: 43nM EC50:  33nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30521(5,6-Dihydro-1H-pyridin-2-one, 4u)copy SMILEScopy InChI
Affinity DataIC50: 46nM EC50:  100nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30535(5,6-Dihydro-1H-pyridin-2-one, 4ag)copy SMILEScopy InChI
Affinity DataIC50: 47nM EC50:  350nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30528(5,6-Dihydro-1H-pyridin-2-one, 4ab)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30517(5,6-Dihydro-1H-pyridin-2-one, 4q)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30515(5,6-Dihydro-1H-pyridin-2-one, 4o)copy SMILEScopy InChI
Affinity DataIC50: 51nM EC50:  700nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30537(5,6-Dihydro-1H-pyridin-2-one, 4ai)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus genotype 1b (isolate BK) (HCV))
Anadys Pharmaceuticals

LigandPNGBDBM30506(5,6-Dihydro-1H-pyridin-2-one, 4f)copy SMILEScopy InChI
Affinity DataIC50: 57nM EC50:  74nMpH: 7.5 T: 2°CAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme, RNA substrate, and [alpha-33P]GTP/GTP with inhibitor concentration v...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30534(5,6-Dihydro-1H-pyridin-2-one, 4af)copy SMILEScopy InChI
Affinity DataIC50: 63nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
TargetGenome polyprotein(Hepatitis C virus (HCV genotype 1a, isolate H))
Anadys Pharmaceuticals

LigandPNGBDBM30509(5,6-Dihydro-1H-pyridin-2-one, 4i)copy SMILEScopy InChI
Affinity DataIC50: 66nMAssay Description:Assays were performed in a 96-well streptavidin-coated Flash-Plate using enzyme (NS5B H77 1a), RNA substrate, and [alpha-33P]GTP/GTP with inhibitor c...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2JM27Z0PubMed
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