Compile Data Set for Download or QSAR
Found 44 with Last Name = 'coward' and Initial = 'jk'
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50051747(5-Amino-2-{4-[(2-amino-4-hydroxy-5,6,7,8-tetrahydr...)copy SMILEScopy InChI
Affinity DataKi:  200nMAssay Description:Inhibitory activity against mammalian Folyl-polyglutamate synthaseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50060962(2-Amino-4-[1-({[3-(4-amino-butylamino)-propoxy]-hy...)copy SMILEScopy InChI
Affinity DataKi:  6.00E+3nMAssay Description:Inhibition of Glutathionylspermidine synthetaseMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP53XBPubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50060962(2-Amino-4-[1-({[3-(4-amino-butylamino)-propoxy]-hy...)copy SMILEScopy InChI
Affinity DataKi:  1.40E+4nMAssay Description:Inhibition of Glutathionylspermidine synthetase from Escherichia coli, value taken from literatureMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP53XBPubMed
TargetGlutathionylspermidine synthase(Crithidia fasciculata)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50060963(O-Methyl-N-[3-[N-(4-aminobutyl)amino]propyl][[(glu...)copy SMILEScopy InChI
Affinity DataKi:  2.40E+4nMAssay Description:Inhibition of Glutathionylspermidine synthetase. Values from different publications.More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP53XBPubMed
TargetCatechol O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367029(CHEMBL553016)copy SMILEScopy InChI
Affinity DataKi:  5.00E+5nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5TJMPubMed
TargetCatechol O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367030(CHEMBL539878)copy SMILEScopy InChI
Affinity DataKi:  8.00E+5nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5TJMPubMed
TargetCatechol O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367031(CHEMBL557014)copy SMILEScopy InChI
Affinity DataKi:  8.00E+5nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5TJMPubMed
TargetCatechol O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM22111((2R,3R,4S,5S)-2-(6-amino-9H-purin-9-yl)-5-[(methyl...)copy SMILEScopy InChI
Affinity DataKi: >5.40E+6nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5TJMPubMed
TargetCatechol O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367028(CHEMBL553200)copy SMILEScopy InChI
Affinity DataKi:  5.80E+6nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5TJMPubMed
TargetCatechol O-methyltransferase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366942(CHEMBL540135)copy SMILEScopy InChI
Affinity DataKi:  6.00E+6nMAssay Description:Compound was tested for inhibition of Catechol O-methyltransferase using radiochemical assayMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q26D5TJMPubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)copy SMILEScopy InChI
Affinity DataIC50: 0.820nMAssay Description:Inhibitory concentration against dihydrofolate reductase (DHFR) enzyme isolated from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50049156((2R,4R)-2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-me...)copy SMILEScopy InChI
Affinity DataIC50: 0.840nMAssay Description:Inhibitory activity against Dihydrofolate reductase (DHFR) isolated from CCRF-CEM human leukemia cells in experiment 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81DR3PubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50011886(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against dihydrofolate reductase enzyme (DHFR) enzyme isolated from CCRF-CEM human leukemia cells. value mentioned is from li...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)copy SMILEScopy InChI
Affinity DataIC50: 1.18nMAssay Description:Inhibitory activity against Dihydrofolate reductase (DHFR) isolated from CCRF-CEM human leukemia cells in experiment 1More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50051746(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibitory concentration against dihydrofolate reductase enzyme (DHFR) enzyme isolated from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50049154(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Inhibitory activity against Dihydrofolate reductase (DHFR) isolated from CCRF-CEM human leukemia cells in experiment 2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81DR3PubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity against Dihydrofolate reductase (DHFR) isolated from CCRF-CEM human leukemia cells in experiment 2More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50049155(2-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity against Dihydrofolate reductase (DHFR) isolated from CCRF-CEM human leukemia cells in experiment 1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Q81DR3PubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)copy SMILEScopy InChI
Affinity DataIC50: 1.40nMAssay Description:Inhibitory activity against Dihydrofolate reductase (DHFR) isolated from CCRF-CEM human leukemia cells in experiment 2More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50011886(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibitory concentration against dihydrofolate reductase enzyme (DHFR) enzyme isolated from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
Guilford Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50116251(2-{[3-(4-Amino-benzoylamino)-3-carboxy-propyl]-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21835TNPubMed
TargetSpermidine synthase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50369035(CHEMBL608868)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of prokaryotic Escherichia coli Putrescine aminopropyltransferase was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9HW3PubMed
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
Guilford Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50116250(2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21835TNPubMed
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
Guilford Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50116253(2-{[3-Carboxy-3-(4-methylamino-benzoylamino)-propy...)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21835TNPubMed
TargetGlutamate carboxypeptidase 2(Rattus norvegicus)
Guilford Pharmaceuticals Inc.

Curated by ChEMBL
LigandPNGBDBM50116252(2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Compound was evaluated for its ability to inhibit Glutamate carboxypeptidase-II using N-acetyl-L-aspartyl-[3H]-L-glutamate as substrateMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21835TNPubMed
TargetSpermidine synthase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50369035(CHEMBL608868)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of Putrescine aminopropyl transferase (PAPT) in rat liverMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9HW3PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50116252(2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Compound was evaluated for its ability to inhibit Folylpoly-gamma-glutamyl synthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21835TNPubMed
TargetSpermidine synthase(Rattus norvegicus)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50095449(2-[1-(2-Amino-ethyl)-6-(3-amino-propylamino)-hexyl...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of Spermidine aminopropyltransferase (SAPT) in rat liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9HW3PubMed
TargetSpermidine synthase(Rattus norvegicus)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50095450(2-[6-Amino-1-(2-amino-ethyl)-hexylsulfanylmethyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Inhibition of Putrescine aminopropyl transferase (PAPT) in rat liverMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9HW3PubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50116250(2-[(3-Carboxy-3-{4-[(2,4-diamino-pteridin-6-ylmeth...)copy SMILEScopy InChI
Affinity DataIC50: 120nMAssay Description:Compound was evaluated for its ability to inhibit Folylpoly-gamma-glutamyl synthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21835TNPubMed
TargetSpermidine synthase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50095450(2-[6-Amino-1-(2-amino-ethyl)-hexylsulfanylmethyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 250nMAssay Description:Inhibition of prokaryotic Escherichia coli Putrescine aminopropyltransferase was determinedMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9HW3PubMed
TargetSpermidine synthase(Rattus norvegicus)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50095450(2-[6-Amino-1-(2-amino-ethyl)-hexylsulfanylmethyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Inhibitory activity against spermidine synthaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP763CPubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM18050(2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)a...)copy SMILEScopy InChI
Affinity DataIC50: 720nMAssay Description:Inhibitory activity against purified human dihydrofolate reductase (DHFR) in human leukemia cells (CCRF-CEM)More data for this Ligand-Target Pair
TargetSpermidine synthase(Rattus norvegicus)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50369035(CHEMBL608868)copy SMILEScopy InChI
Affinity DataIC50: 750nMAssay Description:Inhibition of Spermidine aminopropyltransferase (SAPT) in rat liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9HW3PubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50049157(4-{4-[(2,4-Diamino-pteridin-6-ylmethyl)-methyl-ami...)copy SMILEScopy InChI
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibitory activity against purified human dihydrofolate reductase (DHFR) in human leukemia cells (CCRF-CEM)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q21835KHPubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50116253(2-{[3-Carboxy-3-(4-methylamino-benzoylamino)-propy...)copy SMILEScopy InChI
Affinity DataIC50: 5.70E+3nMAssay Description:Compound was evaluated for its ability to inhibit Folylpoly-gamma-glutamyl synthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21835TNPubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50116251(2-{[3-(4-Amino-benzoylamino)-3-carboxy-propyl]-hyd...)copy SMILEScopy InChI
Affinity DataIC50: 8.60E+3nMAssay Description:Compound was evaluated for its ability to inhibit Folylpoly-gamma-glutamyl synthetaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q21835TNPubMed
TargetSpermidine synthase(Rattus norvegicus)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50095449(2-[1-(2-Amino-ethyl)-6-(3-amino-propylamino)-hexyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of Putrescine aminopropyltransferase (PAPT) in rat liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9HW3PubMed
TargetSpermidine synthase(Rattus norvegicus)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50404650(CHEMBL557606)copy SMILEScopy InChI
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibitory activity against spermidine synthaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP763CPubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50011886(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)copy SMILEScopy InChI
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibitory concentration against human Folyl-polyglutamate synthase isolated from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed
TargetSpermidine synthase(Rattus norvegicus)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50404650(CHEMBL557606)copy SMILEScopy InChI
Affinity DataIC50: 8.00E+4nMAssay Description:Inhibitory activity against spermine synthaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP763CPubMed
TargetSpermidine synthase(Rattus norvegicus)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50095450(2-[6-Amino-1-(2-amino-ethyl)-hexylsulfanylmethyl]-...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of Spermidine aminopropyltransferase (SAPT) in rat liver.More data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q23T9HW3PubMed
TargetSpermidine synthase(Rattus norvegicus)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50404649(CHEMBL178068)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+5nMAssay Description:Inhibitory activity against spermidine synthaseMore data for this Ligand-Target Pair
In DepthDetails
BindingDB Entry DOI: 10.7270/Q2XP763CPubMed
TargetFolylpolyglutamate synthase, mitochondrial(Homo sapiens (Human))
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50051746(5-Amino-2-{4-[(2,4-diamino-pteridin-6-ylmethyl)-me...)copy SMILEScopy InChI
Affinity DataIC50: 3.00E+5nMAssay Description:Inhibitory concentration against human Folyl-polyglutamate synthase isolated from CCRF-CEM human leukemia cells.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2000158PubMed