Compile Data Set for Download or QSAR
Found 63 with Last Name = 'gushue' and Initial = 'jm'
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166693(3-Pyridin-3-yl-3-{5-[2-(5,6,7,8-tetrahydro-[1,8]na...)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166695(3-(5-Methoxy-pyridin-3-yl)-3-{5-[2-(5,6,7,8-tetrah...)copy SMILEScopy InChI
Affinity DataIC50: 0.25nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166677(3-(5-Cyano-pyridin-3-yl)-3-{5-[2-(5,6,7,8-tetrahyd...)copy SMILEScopy InChI
Affinity DataIC50: 0.260nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166688(3-(6-Methanesulfonyl-pyridin-3-yl)-3-{5-[2-(5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166678(3-Benzo[1,3]dioxol-5-yl-3-{5-[2-(5,6,7,8-tetrahydr...)copy SMILEScopy InChI
Affinity DataIC50: 0.380nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166683(3-Quinolin-3-yl-3-{5-[2-(5,6,7,8-tetrahydro-[1,8]n...)copy SMILEScopy InChI
Affinity DataIC50: 0.380nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166669(3-(5-Methanesulfonyl-pyridin-3-yl)-3-{5-[2-(5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 0.460nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166675(3-(3-Chloro-phenyl)-3-{5-[2-(5,6,7,8-tetrahydro-[1...)copy SMILEScopy InChI
Affinity DataIC50: 0.5nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166680(3-(4-Methoxy-phenyl)-3-{5-[2-(5,6,7,8-tetrahydro-[...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166668(3-(4-Fluoro-phenyl)-3-{5-[2-(5,6,7,8-tetrahydro-[1...)copy SMILEScopy InChI
Affinity DataIC50: 0.700nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166682(3-(3-Methoxy-phenyl)-3-{5-[2-(5,6,7,8-tetrahydro-[...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166665(3-Pyridin-4-yl-3-{5-[2-(5,6,7,8-tetrahydro-[1,8]na...)copy SMILEScopy InChI
Affinity DataIC50: 0.900nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166691(3-Phenyl-3-{5-[2-(5,6,7,8-tetrahydro-[1,8]naphthyr...)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166692(3-(2-Methoxy-phenyl)-3-{5-[2-(5,6,7,8-tetrahydro-[...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166673(3-Pyridin-2-yl-3-{5-[2-(5,6,7,8-tetrahydro-[1,8]na...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166674(3-{5-[2-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166672(3-{5-[2-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166687(3-Benzo[1,3]dioxol-5-yl-3-{5-[2-(3,4-dihydro-2H-py...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166679(3-{5-[3-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50161783(3-{5-[2-(6-Methylamino-pyridin-2-yl)-ethoxy]-indol...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166666(3-Naphthalen-2-yl-3-{5-[2-(5,6,7,8-tetrahydro-[1,8...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166686(3-Naphthalen-1-yl-3-{5-[2-(5,6,7,8-tetrahydro-[1,8...)copy SMILEScopy InChI
Affinity DataIC50: 37nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166685(3-Biphenyl-4-yl-3-{5-[2-(5,6,7,8-tetrahydro-[1,8]n...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166690(3-(2-Chloro-phenyl)-3-{5-[2-(5,6,7,8-tetrahydro-[1...)copy SMILEScopy InChI
Affinity DataIC50: 55nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166671(3-{5-[2-(5,6,7,8-Tetrahydro-[1,8]naphthyridin-2-yl...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166676(3-{5-[2,2-Difluoro-2-(5,6,7,8-tetrahydro-[1,8]naph...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166681(3-(5-{2-[N-(4,5-Dihydro-1H-imidazol-2-yl)-aminooxy...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31288(1,4-benzodiazepine-2,5-dione scaffold, 2 | BMCL163...)copy SMILEScopy InChI
Affinity DataIC50: 250nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4MZJPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31288(1,4-benzodiazepine-2,5-dione scaffold, 2 | BMCL163...)copy SMILEScopy InChI
Affinity DataIC50: 250nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44F6PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31293(1,4-benzodiazepine-2,5-dione scaffold, 22 | BMCL16...)copy SMILEScopy InChI
Affinity DataIC50: 367nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44F6PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31289(1,4-benzodiazepine-2,5-dione scaffold, 21 | BMCL16...)copy SMILEScopy InChI
Affinity DataIC50: 394nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44F6PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166684(2-Methyl-3-{5-[3-(pyridin-2-ylamino)-propoxy]-indo...)copy SMILEScopy InChI
Affinity DataIC50: 460nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50161784(3-{5-[3-(Pyridin-2-ylamino)-propoxy]-indol-1-yl}-p...)copy SMILEScopy InChI
Affinity DataIC50: 470nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31314(1,4-benzodiazepine-2,5-dione, 12k)copy SMILEScopy InChI
Affinity DataIC50: 546nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44F6PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31289(1,4-benzodiazepine-2,5-dione scaffold, 21 | BMCL16...)copy SMILEScopy InChI
Affinity DataIC50: 700nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4MZJPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31313(1,4-benzodiazepine-2,5-dione, 12j)copy SMILEScopy InChI
Affinity DataIC50: 787nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44F6PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31293(1,4-benzodiazepine-2,5-dione scaffold, 22 | BMCL16...)copy SMILEScopy InChI
Affinity DataIC50: 790nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4MZJPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31287(1,4-benzodiazepine-2,5-dione scaffold, 52)copy SMILEScopy InChI
Affinity DataIC50: 810nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4MZJPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31305(1,4-benzodiazepine-2,5-dione, 12b | BMCL163310 Com...)copy SMILEScopy InChI
Affinity DataIC50: 856nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44F6PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31316(1,4-benzodiazepine-2,5-dione, 12m)copy SMILEScopy InChI
Affinity DataIC50: 1.55E+3nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44F6PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166689(2-Benzyl-3-{5-[3-(pyridin-2-ylamino)-propoxy]-indo...)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetIntegrin alpha-V/beta-3(Homo sapiens (Human))
Johnson& Johnson, Pharmaceutical Research and Development, L.L.C.

Curated by ChEMBL
LigandPNGBDBM50166670(2-{5-[3-(Pyridin-2-ylamino)-propoxy]-indol-1-ylmet...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibitory concentration against alphaV-beta3 integrinMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2N29Z40PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31310(1,4-benzodiazepine-2,5-dione, 12g)copy SMILEScopy InChI
Affinity DataIC50: 2.39E+3nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44F6PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31290(1,4-benzodiazepine-2,5-dione scaffold, 49)copy SMILEScopy InChI
Affinity DataIC50: 2.44E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4MZJPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31295(1,4-benzodiazepine-2,5-dione scaffold, 27)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4MZJPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31306(1,4-benzodiazepine-2,5-dione, 12c)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44F6PubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31296(1,4-benzodiazepine-2,5-dione scaffold, 28)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4MZJPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31300(1,4-benzodiazepine-2,5-dione scaffold, 29)copy SMILEScopy InChI
Affinity DataIC50: 2.83E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4MZJPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31294(1,4-benzodiazepine-2,5-dione scaffold, 23)copy SMILEScopy InChI
Affinity DataIC50: 3.60E+3nMpH: 7.5 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23F4MZJPubMed
TargetE3 ubiquitin-protein ligase Mdm2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical

LigandPNGBDBM31315(1,4-benzodiazepine-2,5-dione, 12l)copy SMILEScopy InChI
Affinity DataIC50: 5.40E+3nMpH: 7.4 T: 2°CAssay Description:Test compound was incubated for 15 minutes with 30 nM peptide fluorescein-FMDYWEGLN (Fl 9mer) and 120 nM (glycine-HDM2 17-125) in assay buffer. The p...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZP44F6PubMed
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