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Found 22 with Last Name = 'marinis' and Initial = 'jm'

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502339(CHEMBL4452233)copy SMILEScopy InChI

IC50: 0.400nMAssay Description:Inhibition of RIP1 in human neutrophils assessed as inhibition of TNF-alpha/QVD-Oph/RMT5265-stimulated MIP-1 beta mRNA overexpression measured at 21 ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502339(CHEMBL4452233)copy SMILEScopy InChI

IC50: 0.400nMAssay Description:Inhibition of RIP1 in human neutrophils assessed as inhibition of TNF-alpha/QVD-Oph/RMT5265-stimulated MIP-1 beta cytokine overproduction measured at...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502339(CHEMBL4452233)copy SMILEScopy InChI

IC50: 0.5nMAssay Description:Inhibition of RIP1 in human neutrophils assessed as inhibition of TNF-alpha/QVD-Oph/RMT5265-stimulated necroptosis by measuring LDH release measured ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50233225(CHEMBL4071864)copy SMILEScopy InChI

IC50: 1nMAssay Description:Inhibition of pDEST8HisGSTTev-tagged human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated with enzyme for 1 hr ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50159507(CHEMBL3785703)copy SMILEScopy InChI

IC50: 1.60nMAssay Description:Inhibition of pDEST8HisGSTTev-tagged human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated with enzyme for 1 hr ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed PDB

3D Structure (crystal)

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502339(CHEMBL4452233)copy SMILEScopy InChI

IC50: 1.60nMAssay Description:Inhibition of RIP1 in human neutrophils assessed as inhibition of TNF-alpha/QVD-Oph/RMT5265-stimulated necroptosis by measuring cellular ATP levels m...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502339(CHEMBL4452233)copy SMILEScopy InChI

IC50: 5nMAssay Description:Inhibition of RIP1 in human whole blood assessed as inhibition of TNF-alpha/QVD-Oph/RMT5265-stimulated MIP-1 beta cytokine overproduction incubated f...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502340(CHEMBL4554676)copy SMILEScopy InChI

IC50: 5nMAssay Description:Inhibition of pDEST8HisGSTTev-tagged human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated with enzyme for 1 hr ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502343(CHEMBL4453758)copy SMILEScopy InChI

IC50: 6.30nMAssay Description:Inhibition of pDEST8HisGSTTev-tagged human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated with enzyme for 1 hr ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502343(CHEMBL4453758)copy SMILEScopy InChI

IC50: 6.30nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in necroptosis incubated for 24 hrs by cell titer-glo luminescent cell viability assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502339(CHEMBL4452233)copy SMILEScopy InChI

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50233225(CHEMBL4071864)copy SMILEScopy InChI

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502339(CHEMBL4452233)copy SMILEScopy InChI

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50159507(CHEMBL3785703)copy SMILEScopy InChI

IC50: 7.90nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in necroptosis incubated for 24 hrs by cell titer-glo luminescent cell viability assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed PDB

3D Structure (crystal)

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502340(CHEMBL4554676)copy SMILEScopy InChI

IC50: 10nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in necroptosis incubated for 24 hrs by cell titer-glo luminescent cell viability assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502341(CHEMBL4068352)copy SMILEScopy InChI

IC50: 32nMAssay Description:Inhibition of pDEST8HisGSTTev-tagged human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated with enzyme for 1 hr ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50159512(CHEMBL3786293)copy SMILEScopy InChI

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502342(CHEMBL4470945)copy SMILEScopy InChI

IC50: 50nMAssay Description:Inhibition of pDEST8HisGSTTev-tagged human RIP1 (1 to 375 residues) expressed in baculovirus infected insect cells preincubated with enzyme for 1 hr ...More data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502342(CHEMBL4470945)copy SMILEScopy InChI

IC50: 63nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in necroptosis incubated for 24 hrs by cell titer-glo luminescent cell viability assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50502341(CHEMBL4068352)copy SMILEScopy InChI

IC50: 100nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in necroptosis incubated for 24 hrs by cell titer-glo luminescent cell viability assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
GlaxoSmithKline

Curated by ChEMBL

BDBM50159512(CHEMBL3786293)copy SMILEScopy InChI

IC50: 200nMAssay Description:Inhibition of RIP1 in human U937 cells assessed as reduction in necroptosis incubated for 24 hrs by cell titer-glo luminescent cell viability assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed

Receptor-interacting serine/threonine-protein kinase 1(Mus musculus)
GlaxoSmithKline

Curated by ChEMBL

BDBM50502339(CHEMBL4452233)copy SMILEScopy InChI

IC50: 1.30E+3nMAssay Description:Inhibition of RIP1 in mouse L929 cells assessed as reduction in necroptosis incubated for 24 hrs by cell titer-glo luminescent cell viability assayMore data for this Ligand-Target Pair

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BindingDB Entry DOI: 10.7270/Q2VT1WB8PubMed