Compile Data Set for Download or QSAR
Found 27 with Last Name = 'wilkinson' and Initial = 'jm'
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16292(3-N-[(2S,3S,5R)-3-amino-5-[(4-fluorophenyl)carbamo...)copy SMILEScopy InChI
Affinity DataKi:  26nM ΔG°:  -42.9kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16291(3-N-[(2S,3S,5R)-3-amino-5-{[(1S)-1-(benzylcarbamoy...)copy SMILEScopy InChI
Affinity DataKi:  33nM ΔG°:  -42.3kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HM0PubMed
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16286(3-N-[(1R,3S,4S)-1-{[(1S)-1-(benzylcarbamoyl)-2-met...)copy SMILEScopy InChI
Affinity DataKi:  71nM ΔG°:  -40.4kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HM0PubMed
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16287(3-N-[(1R,3S,4S)-3-amino-1-{[(1S)-1-(benzylcarbamoy...)copy SMILEScopy InChI
Affinity DataKi:  120nM ΔG°:  -39.1kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HM0PubMed
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16289(3-N-[(1R,3S,4S)-1-[(4-fluorophenyl)carbamoyl]-3-hy...)copy SMILEScopy InChI
Affinity DataKi:  1.30E+3nM ΔG°:  -33.3kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HM0PubMed
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16290(3-N-[(1R,3S,4S)-3-amino-1-[(4-fluorophenyl)carbamo...)copy SMILEScopy InChI
Affinity DataKi:  3.00E+3nM ΔG°:  -31.2kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HM0PubMed
TargetBeta-secretase 1 [22-454](Homo sapiens (Human))
Sunesis

LigandPNGBDBM16288(3-N-[(1R,3R,4S)-3-amino-1-{[(1S)-1-(benzylcarbamoy...)copy SMILEScopy InChI
Affinity DataKi:  1.13E+4nM ΔG°:  -28.0kJ/molepH: 4.5 T: 2°CAssay Description:Compounds were tested for their ability to inhibit BACE-1 hydrolysis of the internally quenched fluorescent substrate FS-2. Reactions were initiated ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2PV6HM0PubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 0.110nMAssay Description:Binding affinity to human HCK using KVEKIGEGTYGVVYK as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 0.160nMAssay Description:Binding affinity to LYN (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMedDrugBank
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 0.280nMAssay Description:Binding affinity to human LCK using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 0.360nMAssay Description:Binding affinity to human FYN using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 0.370nMAssay Description:Binding affinity to human ABL1 using EAIYAAPFAKKK as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Yes(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 0.890nMAssay Description:Binding affinity to human YES using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 1.10nMAssay Description:Binding affinity to human PDGFRalpha using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMedDrugBank
TargetTyrosine-protein kinase FRK(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 1.30nMAssay Description:Binding affinity to human FRK using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Binding affinity to human FGFR1 using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Binding affinity to FLT1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 5.40nMAssay Description:Binding affinity to human SRC using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMedDrugBank
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 9.40nMAssay Description:Binding affinity to DDR1 (unknown origin) at 5 uMMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Binding affinity to MAPK14 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
TargetTyrosine-protein kinase CSK(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 13nMAssay Description:Binding affinity to human CSK using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
TargetTyrosine-protein kinase JAK1(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Binding affinity to human JAK1 using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
TargetEphrin type-A receptor 1(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 143nMAssay Description:Binding affinity to human EPHA1 using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 169nMAssay Description:Binding affinity to human JAK2 using poly[Glu:Tyr] (4:1) as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 613nMAssay Description:Binding affinity to PRKACA (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
TargetLeukocyte tyrosine kinase receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to LTK (unknown origin)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50322535(3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to human IGF1R using KKKSPGEYVNIEFG as substrate by radiometric hotspot kinase assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2WM1J37PubMed