Compile Data Set for Download or QSAR
Found 227 with Last Name = 'yingling' and Initial = 'jm'
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132988(4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132988(4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...)copy SMILEScopy InChI
Affinity DataIC50: 2.90nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132986(4-(3-(3-(trifluoromethyl)phenyl)-1H-pyrazol-4-yl)q...)copy SMILEScopy InChI
Affinity DataIC50: 6.80nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)copy SMILEScopy InChI
Affinity DataIC50: 7.10nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184486(1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184488(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)copy SMILEScopy InChI
Affinity DataIC50: 15nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184483(1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...)copy SMILEScopy InChI
Affinity DataIC50: 22nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21506(Dihydropyrrolopyrazole, 15a | dimethyl[2-({4-[2-(p...)copy SMILEScopy InChI
Affinity DataIC50: 24nM EC50:  29nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132981(4-[5-Methyl-3-(6-methyl-pyridin-2-yl)-1H-pyrazol-4...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132993(4-(3-Phenyl-1H-pyrazol-4-yl)-quinoline | 4-(3-phen...)copy SMILEScopy InChI
Affinity DataIC50: 25nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184483(1-methyl-6-[2-(6-methylpyridin-2-yl)-5,6-dihydro-4...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132988(4-[3-(6-Bromo-pyridin-2-yl)-1H-pyrazol-4-yl]-quino...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132992(4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)phenol...)copy SMILEScopy InChI
Affinity DataIC50: 31nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132992(4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)phenol...)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21505(7-(2-chloroethoxy)-4-[2-(pyridin-2-yl)-4H,5H,6H-py...)copy SMILEScopy InChI
Affinity DataIC50: 33nM EC50:  66nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)copy SMILEScopy InChI
Affinity DataIC50: 34nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)copy SMILEScopy InChI
Affinity DataIC50: 40nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184489(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132976(2-[4-(4-Fluoro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)copy SMILEScopy InChI
Affinity DataIC50: 41nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132987(2-[4-(4-Methoxy-phenyl)-1-methyl-1H-pyrazol-3-yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132992(4-(3-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl)phenol...)copy SMILEScopy InChI
Affinity DataIC50: 44nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Lilly Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50148668(4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibitory activity against TGF-beta type I receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0SCKPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21510(Dihydropyrrolopyrazole, 16a | dimethyl[5-({4-[2-(p...)copy SMILEScopy InChI
Affinity DataIC50: 47nM EC50:  24nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184488(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132987(2-[4-(4-Methoxy-phenyl)-1-methyl-1H-pyrazol-3-yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 47nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase production in mink lung cells (p3TP Lux)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Lilly Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50148666(7-Chloro-4-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...)copy SMILEScopy InChI
Affinity DataIC50: 48nMAssay Description:Inhibitory activity against TGF-beta type I receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0SCKPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21511(1-(4-methylpiperazin-1-yl)-2-({4-[2-(pyridin-2-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 49nM EC50:  260nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184494(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)copy SMILEScopy InChI
Affinity DataIC50: 51nMAssay Description:Inhibition of human Transforming growth factor (TGF) beta-1 receptor (T204D mutation) autophosphorylation in Sf9 cellsMore data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184496(CHEMBL441176 | dimethyl-(3-{6-[2-(6-methyl-pyridin...)copy SMILEScopy InChI
Affinity DataIC50: 53nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Lilly Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50148655(7-Chloro-4-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Inhibitory activity against TGF-beta type I receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0SCKPubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132994(2-[4-(4-Chloro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)copy SMILEScopy InChI
Affinity DataIC50: 59nM EC50:  40nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM21492(4-[3-(pyridin-2-yl)-1H-pyrazol-4-yl]quinoline | CH...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Lilly Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50148657(7-Ethoxy-4-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0SCKPubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132987(2-[4-(4-Methoxy-phenyl)-1-methyl-1H-pyrazol-3-yl]-...)copy SMILEScopy InChI
Affinity DataIC50: 61nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21509(4-[2-({4-[2-(pyridin-2-yl)-4H,5H,6H-pyrrolo[1,2-a]...)copy SMILEScopy InChI
Affinity DataIC50: 69nM EC50:  180nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184487(4-(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-p...)copy SMILEScopy InChI
Affinity DataIC50: 69nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132976(2-[4-(4-Fluoro-phenyl)-1H-pyrazol-3-yl]-6-methyl-p...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:In vitro inhibitory activity against human Transforming growth factor beta-1 receptor kinase (TGF-beta RIK)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Lilly Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50148656(4-(2-(6-ethylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo[...)copy SMILEScopy InChI
Affinity DataIC50: 71nMAssay Description:Inhibitory activity against TGF-beta type I receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0SCKPubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21513(7-[3-(1-methylpyrrolidin-2-yl)propoxy]-4-[2-(pyrid...)copy SMILEScopy InChI
Affinity DataIC50: 72nM EC50:  17nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184497(6-[2-(6-methyl-pyridin-2-yl)-5,6-dihydro-4H-pyrrol...)copy SMILEScopy InChI
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetTGF-beta receptor type-1 [4-503,T204D](Homo sapiens (Human))
Lilly Research Laboratories

LigandPNGBDBM21504(7-[3-(4-methylpiperazin-1-yl)propoxy]-4-[2-(pyridi...)copy SMILEScopy InChI
Affinity DataIC50: 74nM EC50:  44nMpH: 7.5 T: 2°CAssay Description:The kinase activity was assayed by the autophosphorylation reaction of ALK5 (T204D) in the presence of 4 uM ATP and [33P]-gamma-ATP. After incubation...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2G15Z4KPubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184486(1-methyl-6-(2-pyridin-2-yl-5,6-dihydro-4H-pyrrolo[...)copy SMILEScopy InChI
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant human TGFbeta R1 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132980(4-(3-(5-fluoropyridin-2-yl)-1H-pyrazol-4-yl)quinol...)copy SMILEScopy InChI
Affinity DataIC50: 76nMAssay Description:In vitro inhibition of transforming growth factor- beta dependent luciferase growth in mouse fibroblasts (NIH 3T3)More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50132989(4-[3-(6-Methyl-pyridin-2-yl)-1H-pyrazol-4-yl]-quin...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:In vitro inhibitory activity against Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2RV0N38PubMed
TargetTGF-beta receptor type-1(Homo sapiens (Human))
The Lilly Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50184489(3-(6-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrr...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibition of TGFbeta R1 induced transcriptional activation of p3TP-Lux in mink Mv1Lu lung cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2V40TS0PubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Lilly Research Laboratory

Curated by ChEMBL
LigandPNGBDBM50148661(4-(2-(6-methylpyridin-2-yl)-5,6-dihydro-4H-pyrrolo...)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibitory activity against TGF-beta type I receptorMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q23R0SCKPubMed
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