Compile Data Set for Download or QSAR
Found 504 with Last Name = 'simard' and Initial = 'jr'
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM6760((+)-K-252a | CHEMBL281948 | K-252a | methyl (15S,1...)copy SMILEScopy InChI
Affinity DataKi:  20nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22F7NQNPubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50216683(1-(5-iodonaphthalen-1-ylsulfonyl)-1,4-diazepane | ...)copy SMILEScopy InChI
Affinity DataKi:  300nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22F7NQNPubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50216681(1-(5-chloronaphthalen-1-ylsulfonyl)-1,4-diazepane ...)copy SMILEScopy InChI
Affinity DataKi:  3.80E+3nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22F7NQNPubMed
TargetMyosin light chain kinase, smooth muscle(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50111446(5-Chloro-naphthalene-1-sulfonic acid (6-amino-hexy...)copy SMILEScopy InChI
Affinity DataKi:  1.10E+5nMAssay Description:Inhibition of MLCK by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q22F7NQNPubMed
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)copy SMILEScopy InChI
Affinity DataIC50: 0.0800nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)copy SMILEScopy InChI
Affinity DataIC50: 0.220nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZQ4PubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nM Kd:  11nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM13216(BMS-354825 | CHEMBL1421 | DASATINIB | N-(2-Chloro-...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nM Kd:  11nMAssay Description:Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach.More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Homo sapiens (Human))
Technische Universität Dortmund

LigandPNGBDBM25013(4-[2-(4-amino-1,2,5-oxadiazol-3-yl)-1-ethyl-7-[(3S...)copy SMILEScopy InChI
Affinity DataIC50: 0.400nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM31826(4-aminoquinazoline, 2a | BMC163482 Compound 3 | CH...)copy SMILEScopy InChI
Affinity DataIC50: 0.430nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor [696-1210,T790M](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM4567(4-anilinoquinazoline deriv. 2 | BMC163482 Compound...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437147(CHEMBL2403875)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)copy SMILEScopy InChI
Affinity DataIC50: 2nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437152(CHEMBL2403816)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetEpidermal growth factor receptor [696-1210,T790M](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM4583((2E)-N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4...)copy SMILEScopy InChI
Affinity DataIC50: 3nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2R20ZQ4PubMed
TargetEpidermal growth factor receptor [668-1210](Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)copy SMILEScopy InChI
Affinity DataIC50: 3.60nMpH: 7.5 T: 2°CAssay Description:The kinase reaction for EGFR consisted of BSA-supplemented kinase buffer, kinase, peptide, and ATP. For IC50 determinations, 10 different concentrati...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Technische Universität Dortmund

LigandPNGBDBM92356(Chir98014, 20)copy SMILEScopy InChI
Affinity DataIC50: 4.10nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1PNHPubMed
TargetPutative glycogen synthase kinase 3 alpha(Ustilago maydis (Smut fungus))
Technische Universität Dortmund

LigandPNGBDBM92356(Chir98014, 20)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1PNHPubMed
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Homo sapiens (Human))
Technische Universität Dortmund

LigandPNGBDBM50313650(8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]tr...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q218358GPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)copy SMILEScopy InChI
Affinity DataIC50: 6.30nM Kd:  8nMAssay Description:Tyrosine kinase inhibition assay using wild type cSrc measured by a fluorescence-labeled approach.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q20V8B46PubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetPutative glycogen synthase kinase 3 alpha(Ustilago maydis (Smut fungus))
Technische Universität Dortmund

LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1PNHPubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM14847(1-[2-(3-Aminophenyl)-5-tert-butyl-2H-pyrazol-3-yl]...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of N-terminus His-tagged human p38alpha expressed in Escherichia coli BL21 DE3 using GST-tagged ATF2 as substrate after 90 mins by HTRF as...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Technische Universität Dortmund

LigandPNGBDBM25036(CHEMBL393525 | N'-[(1E)-{6-bromoimidazo[1,2-a]pyri...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Homo sapiens (Human))
Technische Universität Dortmund

LigandPNGBDBM153703(2-(4-((4-(5-Chloro-2-oxo-2,3-dihydro-1H-benzo[d]im...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q218358GPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM31829(RL46 | quinazoline-pyrazolourea hybrid compound, 3...)copy SMILEScopy InChI
Affinity DataIC50: 14nM Kd:  56nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1QD3PubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437152(CHEMBL2403816)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of DDR2 (unknown origin) after 120 mins by radiometric assay in presence of gamma-[33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50362099(CHEMBL1738943 | Thiazole-urea, 9)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM31828(quinazoline-pyrazolourea hybrid compound, 3b)copy SMILEScopy InChI
Affinity DataIC50: 21nM Kd:  73nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM31829(RL46 | quinazoline-pyrazolourea hybrid compound, 3...)copy SMILEScopy InChI
Affinity DataIC50: 23nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1QD3PubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)copy SMILEScopy InChI
Affinity DataIC50: 24nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50014338(CHEMBL3261118)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Homo sapiens (Human))
Technische Universität Dortmund

LigandPNGBDBM50237622(4-(4-Chlorobenzyl)-1-(7H-pyrrolo[2,3-d]pyrimidin-4...)copy SMILEScopy InChI
Affinity DataIC50: 29nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q218358GPubMed
TargetRAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S](Homo sapiens (Human))
Technische Universität Dortmund

LigandPNGBDBM153702(2-(4-((4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-...)copy SMILEScopy InChI
Affinity DataIC50: 33nMAssay Description:IC50 determinations for activated Akt1 were measured with the KinEASE assay (Cisbio) according to the manufacturer’s instructions. The kinases A...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q218358GPubMed
TargetProto-oncogene tyrosine-protein kinase Src [251-533,T338M](Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM31828(quinazoline-pyrazolourea hybrid compound, 3b)copy SMILEScopy InChI
Affinity DataIC50: 34nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303597((S)-2-(2-amino-3-phenylpropylamino)-3-methyl-5-(na...)copy SMILEScopy InChI
Affinity DataIC50: 35nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0FKCPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50266947(2-(6-chloro-5-((2R,5S)-4-(4-fluorobenzyl)-2,5-dime...)copy SMILEScopy InChI
Affinity DataIC50: 36nMAssay Description:Inhibition of p38alpha active form expressed in Escherichia coli BL21(DE3) cells by HTRF assayMore data for this Ligand-Target Pair
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50437152(CHEMBL2403816)copy SMILEScopy InChI
Affinity DataIC50: 39nMAssay Description:Inhibition of DDR1 (unknown origin) after 120 mins by radiometric assay in presence of gamma-[33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM50303586(1-(3-tert-Butyl-1-(3-nitrophenyl)-1H-pyrazol-5-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0FKCPubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM26474(5-({4-[(2,3-dimethyl-2H-indazol-6-yl)(methyl)amino...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of wild type DDR2 (unknown origin) preincubated for 30 mins before substrate addition by FRET assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetPutative glycogen synthase kinase 3 alpha(Ustilago maydis (Smut fungus))
Technische Universität Dortmund

LigandPNGBDBM25115(3-[(4-bromo-2,6-difluorophenyl)methoxy]-5-({[4-(py...)copy SMILEScopy InChI
Affinity DataIC50: 54nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1PNHPubMed
TargetPutative glycogen synthase kinase 3 alpha(Ustilago maydis (Smut fungus))
Technische Universität Dortmund

LigandPNGBDBM92353(Sorafenib derivative, 16)copy SMILEScopy InChI
Affinity DataIC50: 57nMAssay Description:Inhibition of UmGSK3 by kinase inhibitors.More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1PNHPubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50362099(CHEMBL1738943 | Thiazole-urea, 9)copy SMILEScopy InChI
Affinity DataIC50: 65nMAssay Description:Inhibition of DDR2 (unknown origin) after 120 mins by radiometric assay in presence of gamma-[33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetEpithelial discoidin domain-containing receptor 1(Homo sapiens (Human))
Technical University of Dortmund

Curated by ChEMBL
LigandPNGBDBM50362099(CHEMBL1738943 | Thiazole-urea, 9)copy SMILEScopy InChI
Affinity DataIC50: 68nMAssay Description:Inhibition of DDR1 (unknown origin) after 120 mins by radiometric assay in presence of gamma-[33P]-ATPMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2Z039P4PubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Chemical Genomics Centre of the Max Planck Society

Curated by ChEMBL
LigandPNGBDBM31825(1-(1-(3-Aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl)...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Displacemnt of N,N'-(2,2'-(3,3'-disulfanediylbis(2,5-dioxopyrrolidine-3,1-diyl))bis(ethane-2,1-diyl))bis(2-(3-(3-tert-butyl-5-(3-naphthalen-1-ylureid...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29W0FKCPubMed
TargetProto-oncogene tyrosine-protein kinase Src(Gallus gallus (Chicken))
Chemical Genomics Centre of the Max Planck Society

LigandPNGBDBM31827(quinazoline-pyrazolourea hybrid compound, 3a)copy SMILEScopy InChI
Affinity DataIC50: 71nM Kd:  174nMpH: 7.0 T: 2°CAssay Description:IC50 determinations for cSrc kinases were measured with the HTRF KinEASE-TK assay from Cisbio according to the manufacturer instructions. A biotinyla...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2VT1QD3PubMed
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