Compile Data Set for Download or QSAR
Found 134 with Last Name = 'liu' and Initial = 'jx'
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 0.800nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetTyrosine-protein kinase ABL1(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 1.20nMAssay Description:Inhibition of Abl1More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of RETMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 2.20nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 2.5nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 2.60nMAssay Description:Inhibition of DDR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339615((2S)-7-({2-[(Cyclopropylcarbonyl)amino]pyridin-4-y...)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 4.20nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339613((2S)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]...)copy SMILEScopy InChI
Affinity DataIC50: 4.5nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339616(7-({2-[(Cyclopropylcarbonyl)amino]pyridin-4-yl}oxy...)copy SMILEScopy InChI
Affinity DataIC50: 4.60nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 4.70nMAssay Description:Inhibition of wild-type B-RafMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM16673(4-[4-({[4-chloro-3-(trifluoromethyl)phenyl]carbamo...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMedDrugBank
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339611((2S)-7-{[2-(acetylamino)pyridin-4-yl]oxy}-N-[3-(am...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339614((2R)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]...)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339612(CHEMBL1688868 | N-[3-(Aminomethyl)-5-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 6.20nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of DDR2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339623(4-[3-(3-{[4-Chloro-3-(trifluoromethyl)phenyl]amino...)copy SMILEScopy InChI
Affinity DataIC50: 9nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339622(4-[4-(3-{[4-Chloro-3-(trifluoromethyl)phenyl]amino...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339610(4-{[7-({[3-(Aminomethyl)-5-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of EPHA2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339625(4-{[7-({[4-(Aminomethyl)-3-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50343948((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of B-RafMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP53M9PubMed
TargetEphrin type-A receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inhibition of EPHA2More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50343948((5-(2-hydroxyphenyl)-3-(pyridin-3-yl)-4,5-dihydro-...)copy SMILEScopy InChI
Affinity DataIC50: 27nMAssay Description:Inhibition of C-RafMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2MP53M9PubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339624(CHEMBL1688864 | rac-4-{[7-({[4-Chloro-3-(trifluoro...)copy SMILEScopy InChI
Affinity DataIC50: 28nMAssay Description:Inhibition of C-Raf assessed as reduction in [33P]ATP incorporation into biotinylated substrate peptide after 3 hrs by flash plate assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 42nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339621(3-[(methylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,8-...)copy SMILEScopy InChI
Affinity DataIC50: 45nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 59nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 60nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339619(CHEMBL1688874 | N-[(2R)-7-({2-[(cyclopropylcarbony...)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339618((2S)-N-[3-(2-aminopropan-2-yl)-5-(trifluoromethyl)...)copy SMILEScopy InChI
Affinity DataIC50: 79nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetMitogen-activated protein kinase 14(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 91nMAssay Description:Inhibition of p38alphaMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339617((2S)-N-[3-[(Isopropylamino)methyl]-5-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 110nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339615((2S)-7-({2-[(Cyclopropylcarbonyl)amino]pyridin-4-y...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339613((2S)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]...)copy SMILEScopy InChI
Affinity DataIC50: 130nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339612(CHEMBL1688868 | N-[3-(Aminomethyl)-5-(trifluoromet...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339611((2S)-7-{[2-(acetylamino)pyridin-4-yl]oxy}-N-[3-(am...)copy SMILEScopy InChI
Affinity DataIC50: 150nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 170nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339608(3-(1-Amino-1-methylethyl)-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339616(7-({2-[(Cyclopropylcarbonyl)amino]pyridin-4-yl}oxy...)copy SMILEScopy InChI
Affinity DataIC50: 190nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339609(3-[(Dimethylamino)methyl]-N-{(2R)-7-[(7-oxo-5,6,7,...)copy SMILEScopy InChI
Affinity DataIC50: 610nMAssay Description:Inhibition of LCKMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339614((2R)-N-[3-(aminomethyl)-5-(trifluoromethyl)phenyl]...)copy SMILEScopy InChI
Affinity DataIC50: 780nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50321610(7-((6-chloropyridin-3-yl)methoxy)-2-(4-((6-chlorop...)copy SMILEScopy InChI
Affinity DataIC50: 800nMAssay Description:Inhibition of human telomerase in human SGC7901 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8MPCPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339620(CHEMBL1688875 | N-[(2S)-7-({2-[(Cyclopropylcarbony...)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Millennium Pharmaceuticals, Inc.

Curated by ChEMBL
LigandPNGBDBM50339610(4-{[7-({[3-(Aminomethyl)-5-(trifluoromethyl)phenyl...)copy SMILEScopy InChI
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of raf kinase in human A375 cells assessed as decrease in MEK-mediated ERK phosphorylation after 3 hrs using 3,3',5,5'-tetramethylbenzidin...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2DB824FPubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50327442(3-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of telomerase in human SGC7901 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84C30PubMed
TargetTelomerase reverse transcriptase(Homo sapiens (Human))
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50327440(3-(1-acetyl-5-phenyl-4,5-dihydro-1H-pyrazol-3-yl)-...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of telomerase in human SGC7901 cells by TRAP assayMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2P84C30PubMed
TargetDNA polymerase I, thermostable(Thermus aquaticus)
Nanjing University

Curated by ChEMBL
LigandPNGBDBM50321610(7-((6-chloropyridin-3-yl)methoxy)-2-(4-((6-chlorop...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Thermus aquaticus taq polymeraseMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q28G8MPCPubMed
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