Compile Data Set for Download or QSAR
Found 49 with Last Name = 'furumoto' and Initial = 'k'
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50317662(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010471(CHEMBL3263999)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)copy SMILEScopy InChI
Affinity DataIC50: 23nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331872(5-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 30nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010465(CHEMBL3263996)copy SMILEScopy InChI
Affinity DataIC50: 32nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331871(5-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)copy SMILEScopy InChI
Affinity DataIC50: 50nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010462(CHEBI:78825 | CHEMBL3264002 | US11147816, RO512676...)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010473(CHEMBL3264001)copy SMILEScopy InChI
Affinity DataIC50: 56nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010467(CHEMBL3263995)copy SMILEScopy InChI
Affinity DataIC50: 70nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010469(CHEMBL3092179)copy SMILEScopy InChI
Affinity DataIC50: 78nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331870(4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 80nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010472(CHEMBL3264000)copy SMILEScopy InChI
Affinity DataIC50: 81nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331866(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331867(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331868(6-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331869(6-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331865(4-(3-Phenyl-4,4-dimethyl-5-oxo-2-thioxoimidazolidi...)copy SMILEScopy InChI
Affinity DataIC50: 100nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50317662(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331865(4-(3-Phenyl-4,4-dimethyl-5-oxo-2-thioxoimidazolidi...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)copy SMILEScopy InChI
Affinity DataIC50: 200nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010464(CHEMBL3092189)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331867(3-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 300nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331866(3-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)copy SMILEScopy InChI
Affinity DataIC50: 400nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331868(6-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM18525(Bicalutamide | CHEMBL409 | N-[4-cyano-3-(trifluoro...)copy SMILEScopy InChI
Affinity DataIC50: 600nMAssay Description:Antagonist activity at AR in human bicalutamide-resistant LNCAP cells assessed as inhibition of cell proliferation after 6 daysMore data for this Ligand-Target Pair
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331869(6-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 700nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331872(5-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331870(4-[3-(4-Cyano-3-trifluoromethylphenyl)-5,5-dimethy...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetAndrogen receptor(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd

Curated by ChEMBL
LigandPNGBDBM50331871(5-[3-(3-Chloro-4-cyanophenyl)-5,5-dimethyl-4-oxo-2...)copy SMILEScopy InChI
Affinity DataIC50: 2.00E+3nMAssay Description:Antagonist activity at human AR expressed in human HeLa cells co-transfected with MMTV-Luc-Hyg after 48 hrs by transient-luciferase reporter gene ass...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q29S1S1PPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010466(CHEMBL3263994)copy SMILEScopy InChI
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010464(CHEMBL3092189)copy SMILEScopy InChI
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)copy SMILEScopy InChI
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010462(CHEBI:78825 | CHEMBL3264002 | US11147816, RO512676...)copy SMILEScopy InChI
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010464(CHEMBL3092189)copy SMILEScopy InChI
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of N...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)copy SMILEScopy InChI
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010463(CHEMBL3092195)copy SMILEScopy InChI
Affinity DataIC50: 2.60E+4nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of N...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010470(CHEMBL3263998)copy SMILEScopy InChI
Affinity DataIC50: 2.70E+4nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010464(CHEMBL3092189)copy SMILEScopy InChI
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010468(CHEMBL3263997)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010474(CHEMBL3264003)copy SMILEScopy InChI
Affinity DataIC50: 5.00E+4nMAssay Description:Inhibition of truncated active C-Raf (unknown origin) assessed as MEK1 phosphorylation using inactive MEK1 K97R as substrate after 45 minsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010462(CHEBI:78825 | CHEMBL3264002 | US11147816, RO512676...)copy SMILEScopy InChI
Affinity DataIC50: 6.00E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010464(CHEMBL3092189)copy SMILEScopy InChI
Affinity DataIC50: 9.60E+4nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010465(CHEMBL3263996)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010465(CHEMBL3263996)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP2C9 in human liver microsomes using diclofenac as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010465(CHEMBL3263996)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of N...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010462(CHEBI:78825 | CHEMBL3264002 | US11147816, RO512676...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010465(CHEMBL3263996)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in presence of ...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Chugai Pharmaceutical Co., Ltd.

Curated by ChEMBL
LigandPNGBDBM50010462(CHEBI:78825 | CHEMBL3264002 | US11147816, RO512676...)copy SMILEScopy InChI
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of CYP3A4 in human liver microsomes using midazolam as substrate measured after 30 mins preincubation by LC-MS/MS analysis in absence of N...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27W6DQDPubMed