TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Wake Forest University School of Medicine
Curated by ChEMBL
Wake Forest University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:TP_TRANSPORTER: cell accumulation in MCF7/MRP1-M24 cellsMore data for this Ligand-Target Pair
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Wake Forest University School of Medicine
Curated by ChEMBL
Wake Forest University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.5nMAssay Description:TP_TRANSPORTER: cell accumulation in MCF7/MRP1-M6 cellsMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Wake Forest University School of Medicine
Curated by ChEMBL
Wake Forest University School of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:TP_TRANSPORTER: cell accumulation in MCF7/MRP1-10 cellsMore data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 3.90nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 5.10nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 7.30nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 8.30nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 9.70nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
Affinity DataIC50: 9.80nMAssay Description:Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC
Curated by ChEMBL
Janssen Research& Development LLC
Curated by ChEMBL
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
Affinity DataIC50: 17nMAssay Description:Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...More data for this Ligand-Target Pair
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development
Curated by ChEMBL
Janssen Research and Development
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Affinity DataIC50: 21nMAssay Description:Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...More data for this Ligand-Target Pair
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