Compile Data Set for Download or QSAR
Found 204 with Last Name = 'herman' and Initial = 'k'
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402386(CHEMBL2207747)copy SMILEScopy InChI
Affinity DataIC50: 0.300nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402382(CHEMBL2207751)copy SMILEScopy InChI
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Wake Forest University School of Medicine

Curated by ChEMBL
LigandPNGBDBM67690(1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-bis...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:TP_TRANSPORTER: cell accumulation in MCF7/MRP1-M24 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5PDSPubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Wake Forest University School of Medicine

Curated by ChEMBL
LigandPNGBDBM67690(1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-bis...)copy SMILEScopy InChI
Affinity DataIC50: 1.5nMAssay Description:TP_TRANSPORTER: cell accumulation in MCF7/MRP1-M6 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5PDSPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50425166(CHEMBL2313573)copy SMILEScopy InChI
Affinity DataIC50: 1.60nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetMultidrug resistance-associated protein 1(Homo sapiens (Human))
Wake Forest University School of Medicine

Curated by ChEMBL
LigandPNGBDBM67690(1,4-bis[2-(2-hydroxyethylamino)ethylamino]-5,8-bis...)copy SMILEScopy InChI
Affinity DataIC50: 1.90nMAssay Description:TP_TRANSPORTER: cell accumulation in MCF7/MRP1-10 cellsMore data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2GT5PDSPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402384(CHEMBL2207749)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402403(CHEMBL2207730)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402391(CHEMBL2207742)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50425168(CHEMBL2313571)copy SMILEScopy InChI
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM220233(US9290476, 77A | US9290476, 77B | US9290476, 77C)copy SMILEScopy InChI
Affinity DataIC50: 3.30nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50425170(CHEMBL2313569)copy SMILEScopy InChI
Affinity DataIC50: 3.70nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM220233(US9290476, 77A | US9290476, 77B | US9290476, 77C)copy SMILEScopy InChI
Affinity DataIC50: 3.90nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402392(CHEMBL2207741)copy SMILEScopy InChI
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50425151(CHEMBL2313563)copy SMILEScopy InChI
Affinity DataIC50: 4.60nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402383(CHEMBL2207750)copy SMILEScopy InChI
Affinity DataIC50: 5nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510354(CHEMBL4441287)copy SMILEScopy InChI
Affinity DataIC50: 5.10nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402385(CHEMBL2207748)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402405(CHEMBL2207752)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402395(CHEMBL2207738)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402388(CHEMBL2207745)copy SMILEScopy InChI
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402394(CHEMBL2207739)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50425163(CHEMBL2313266)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402393(CHEMBL2207740)copy SMILEScopy InChI
Affinity DataIC50: 7nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50425164(CHEMBL2313265)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50425167(CHEMBL2313572)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50425157(CHEMBL2313272)copy SMILEScopy InChI
Affinity DataIC50: 7.30nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510357(CHEMBL4543938)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402397(CHEMBL2207736)copy SMILEScopy InChI
Affinity DataIC50: 8nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50425147(CHEMBL2313567)copy SMILEScopy InChI
Affinity DataIC50: 8.30nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM24220(1-(1-{2-[4-(1,3-benzothiazol-2-yloxy)phenoxy]ethyl...)copy SMILEScopy InChI
Affinity DataIC50: 9.70nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetLeukotriene A-4 hydrolase(Mus musculus)
Janssen Research& Development, LLC

Curated by ChEMBL
LigandPNGBDBM50425166(CHEMBL2313573)copy SMILEScopy InChI
Affinity DataIC50: 9.80nMAssay Description:Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510349(CHEMBL4434891)copy SMILEScopy InChI
Affinity DataIC50: 10nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402390(CHEMBL2207743)copy SMILEScopy InChI
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510357(CHEMBL4543938)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510355(CHEMBL4552142)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510352(CHEMBL4468588)copy SMILEScopy InChI
Affinity DataIC50: 12nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339252(US10201546, Example 126b)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human full length RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402387(CHEMBL2207746)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339276(US10201546, Example 136a)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50425148(CHEMBL2313566)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of recombinant human LTA4H expressed in Sf9 cells using LTA4 as substrate incubated for 10 mins prior to substrate addition measured after...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402389(CHEMBL2207744)copy SMILEScopy InChI
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Homo sapiens (Human))
Janssen Research& Development LLC

Curated by ChEMBL
LigandPNGBDBM50402396(CHEMBL2207737)copy SMILEScopy InChI
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant LTA4 hydrolase expressed in SF9 cells using LTA4 as substrate assessed as LTB4 production incubated for 10 mins prior...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2ZG6TDQPubMed
TargetLeukotriene A-4 hydrolase(Mus musculus)
Janssen Research& Development, LLC

Curated by ChEMBL
LigandPNGBDBM50425170(CHEMBL2313569)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339227(US10201546, Example 112c | US10201546, Example 191...)copy SMILEScopy InChI
Affinity DataIC50: 17nMAssay Description:Inverse agonist activity at RORgammat in human PBMC derived CD4-positive T cells assessed as suppression of T cell differentiation to Th17 cells by m...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM50510352(CHEMBL4468588)copy SMILEScopy InChI
Affinity DataIC50: 18nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339216((4-Chloro-3-((4,4-difluoropiperidin-1-yl)methyl)-2...)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetLeukotriene A-4 hydrolase(Mus musculus)
Janssen Research& Development, LLC

Curated by ChEMBL
LigandPNGBDBM50425148(CHEMBL2313566)copy SMILEScopy InChI
Affinity DataIC50: 19nMAssay Description:Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
TargetNuclear receptor ROR-gamma(Homo sapiens (Human))
Janssen Research and Development

Curated by ChEMBL
LigandPNGBDBM339134(US10201546, Example 68a)copy SMILEScopy InChI
Affinity DataIC50: 20nMAssay Description:Inverse agonist activity at GAL4-DNA binding domain-fused human RORgammat LBD expressed in pGL4.31 transfected HEK293T cells assessed as inhibition o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q2862KRTPubMed
TargetLeukotriene A-4 hydrolase(Mus musculus)
Janssen Research& Development, LLC

Curated by ChEMBL
LigandPNGBDBM50425151(CHEMBL2313563)copy SMILEScopy InChI
Affinity DataIC50: 21nMAssay Description:Inhibition of LTA4H in CD1 mouse whole blood assessed as decrease in calcium ionophore-stimulated LTB4 production incubated for 15 mins prior to calc...More data for this Ligand-Target Pair
In DepthDetails Article
BindingDB Entry DOI: 10.7270/Q27H1KW1PubMed
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